Author results

4GGV
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CRYSTAL STRUCTURE OF HMTT INVOLVED IN HIMASTATIN BIOSYNTHESIS
Descriptor:Cytochrome P450 superfamily protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhang, H., Chen, J., Wang, H., Zhang, H.
Deposit date:2012-08-07
Release date:2013-07-17
Method:X-RAY DIFFRACTION (2.331 Å)
Cite:Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis
Febs Lett., 587, 2013
4LA1
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CRYSTAL STRUCTURE OF SJTGR (THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA JAPONICUMI)COMPLEX WITH FAD
Descriptor:Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Peng, Y., Wu, Q., Huang, F., Chen, J., Li, X., Zhou, X., Fan, X.
Deposit date:2013-06-18
Release date:2014-07-30
Method:X-RAY DIFFRACTION (2.348 Å)
Cite:Crystal structure of SjTGR complex with FAD
To be Published
4RY2
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CRYSTAL STRUCTURE OF THE PEPTIDASE-CONTAINING ABC TRANSPORTER PCAT1
Descriptor:ABC-type bacteriocin transporter
Authors:Lin, D.L., Huang, S., Chen, J.
Deposit date:2014-12-13
Release date:2015-07-22
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (3.611 Å)
Cite:Crystal structures of a polypeptide processing and secretion transporter.
Nature, 523, 2015
4S0F
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CRYSTAL STRUCTURE OF THE PEPTIDASE-CONTAINING ABC TRANSPORTER PCAT1 E648Q MUTANT COMPLEXED WITH ATPGS IN AN OCCLUDED CONFORMATION
Descriptor:ABC-type bacteriocin transporter, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Lin, D.L., Huang, S., Chen, J.
Deposit date:2014-12-30
Release date:2015-07-22
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (5.515 Å)
Cite:Crystal structures of a polypeptide processing and secretion transporter.
Nature, 523, 2015
5DH6
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TWO DIVALENT METAL IONS AND CONFORMATIONAL CHANGES PLAY ROLES IN THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION-G12A MUTANT IN MG2+
Descriptor:hammerhead ribozyme, 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3', MAGNESIUM ION
Authors:Mir, A., Chen, J., Neau, D., Golden, B.L.
Deposit date:2015-08-29
Release date:2015-10-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.784 Å)
Cite:Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.
Biochemistry, 54, 2015
5DH7
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TWO DIVALENT METAL IONS AND CONFORMATIONAL CHANGES PLAY ROLES IN THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION-G12A MUTANT IN MN2+
Descriptor:RNA (48-MER), 5'-R(*GP*GP*GP*CP*GP*UP*DC*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3', MANGANESE (II) ION
Authors:Mir, A., Chen, J., Neau, D., Golden, B.L.
Deposit date:2015-08-29
Release date:2015-10-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.064 Å)
Cite:Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.
Biochemistry, 54, 2015
5DH8
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TWO DIVALENT METAL IONS AND CONFORMATIONAL CHANGES PLAY ROLES IN THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION- G12A MUTANT IN ZN2+
Descriptor:RNA (48-MER), 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3', ZINC ION
Authors:Mir, A., Chen, J., Neau, D., Golden, B.L.
Deposit date:2015-08-29
Release date:2015-10-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.297 Å)
Cite:Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.
Biochemistry, 54, 2015
5DI2
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TWO DIVALENT METAL IONS AND CONFORMATIONAL CHANGES PLAY ROLES IN THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION-WT RIBOZYME IN MN2+ AT HIGH PH
Descriptor:RNA (48-MER), 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3', MANGANESE (II) ION
Authors:Mir, A., Chen, J., Neau, D., Golden, B.L.
Deposit date:2015-08-31
Release date:2015-10-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.
Biochemistry, 54, 2015
5DI4
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TWO DIVALENT METAL IONS AND CONFORMATIONAL CHANGES PLAY ROLES IN THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION-WT RIBOZYME IN MN2+ AT LOW PH
Descriptor:RNA (48-MER), 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3', MANGANESE (II) ION
Authors:Mir, A., Chen, J., Neau, D., Golden, B.L.
Deposit date:2015-08-31
Release date:2015-10-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.948 Å)
Cite:Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.
Biochemistry, 54, 2015
5DQK
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TWO DIVALENT METAL IONS AND CONFORMATIONAL CHANGES PLAY ROLES IN THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION-WT RIBOZYME IN MG2+
Descriptor:RNA (48-MER), RNA (5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3'), MAGNESIUM ION, ...
Authors:Mir, A., Chen, J., Neau, D., Golden, B.L.
Deposit date:2015-09-14
Release date:2015-10-07
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.707 Å)
Cite:Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.
Biochemistry, 54, 2015
5M5Z
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CHAETOMIUM THERMOPHILUM BETA-1-3-GLUCANASE
Descriptor:Beta-1,3-glucanase, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Papageorgiou, A.C., Chen, J., Li, D.
Deposit date:2016-10-23
Release date:2017-05-17
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structure and biological implications of a glycoside hydrolase family 55 beta-1,3-glucanase from Chaetomium thermophilum.
Biochim. Biophys. Acta, 1865, 2017
5M60
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CHAETOMIUM THERMOPHILUM BETA-1-3-GLUCANASE
Descriptor:Beta-1,3-glucanase, BETA-D-GLUCOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Papageorgiou, A.C., Chen, J., Li, D.
Deposit date:2016-10-23
Release date:2017-05-17
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure and biological implications of a glycoside hydrolase family 55 beta-1,3-glucanase from Chaetomium thermophilum.
Biochim. Biophys. Acta, 1865, 2017
5TXV
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HSLU P21 CELL WITH 4 HEXAMERS
Descriptor:ATP-dependent protease ATPase subunit HslU, ADENOSINE-5'-DIPHOSPHATE
Authors:Grant, R.A., Chen, J., Glynn, S.E., Sauer, R.T.
Deposit date:2016-11-17
Release date:2017-03-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (7.086 Å)
Cite:Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation.
J. Biol. Chem., 292, 2017
5U1D
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CRYO-EM STRUCTURE OF THE HUMAN TAP ATP-BINDING CASSETTE TRANSPORTER
Descriptor:Antigen peptide transporter 1, Antigen peptide transporter 2, TAP transporter inhibitor ICP47
Authors:Oldham, M.L., Chen, J., Grigorieff, N.
Deposit date:2016-11-28
Release date:2017-01-11
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structure of the transporter associated with antigen processing trapped by herpes simplex virus.
Elife, 5, 2016
5UAK
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DEPHOSPHORYLATED, ATP-FREE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)
Descriptor:Cystic fibrosis transmembrane conductance regulator
Authors:Liu, F., Zhang, Z., Chen, J.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2017-04-12
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Molecular Structure of the Human CFTR Ion Channel.
Cell, 169, 2017
5UAR
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DEPHOSPHORYLATED, ATP-FREE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) FROM ZEBRAFISH
Descriptor:Cystic fibrosis transmembrane conductance regulator, DECANE
Authors:Zhang, Z., Chen, J.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator.
Cell, 167, 2016
5UJ9
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CRYO-EM STRUCTURE OF BOVINE MULTIDRUG RESISTANCE PROTEIN 1 (MRP1)
Descriptor:bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1
Authors:Johnson, Z.L., Chen, J.
Deposit date:2017-01-17
Release date:2017-02-22
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
Cell, 168, 2017
5UJA
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CRYO-EM STRUCTURE OF BOVINE MULTIDRUG RESISTANCE PROTEIN 1 (MRP1) BOUND TO LEUKOTRIENE C4
Descriptor:bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1, (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid
Authors:Johnson, Z.E., Chen, J.
Deposit date:2017-01-17
Release date:2017-02-22
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
Cell, 168, 2017
5W81
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PHOSPHORYLATED, ATP-BOUND STRUCTURE OF ZEBRAFISH CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)
Descriptor:Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Zhang, Z., Liu, F., Chen, J.
Deposit date:2017-06-21
Release date:2017-07-19
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Conformational Changes of CFTR upon Phosphorylation and ATP Binding.
Cell, 170, 2017
5ZN8
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CRYSTAL STRUCTURE OF NICOTINAMIDASE PNCA FROM BACILLUS SUBTILIS
Descriptor:Isochorismatase, ZINC ION
Authors:Shang, F., Chen, J., Wang, L., Xu, Y.
Deposit date:2018-04-08
Release date:2018-04-25
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis.
Biochem.Biophys.Res.Commun., 503, 2018
6A8L
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CRYSTAL STRUCTURE OF NICOTINAMIDASE/ PYRAZINAMIDASE PNCA FROM BACILLUS SUBTILIS
Descriptor:Isochorismatase, ZINC ION
Authors:Shang, F., Chen, J., Wang, L., Xu, Y.
Deposit date:2018-07-09
Release date:2018-08-01
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis.
Biochem. Biophys. Res. Commun., 503, 2018
6BHU
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CRYO-EM STRUCTURE OF ATP-BOUND, OUTWARD-FACING BOVINE MULTIDRUG RESISTANCE PROTEIN 1 (MRP1)
Descriptor:Multidrug resistance-associated protein 1, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Johnson, Z.L., Chen, J.
Deposit date:2017-10-31
Release date:2017-12-27
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1.
Cell, 172, 2018
6BZO
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MTB RNAP HOLO/RBPA/FIDAXOMICIN/UPSTREAM FORK DNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2017-12-25
Release date:2018-03-28
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C0V
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MOLECULAR STRUCTURE OF HUMAN P-GLYCOPROTEIN IN THE ATP-BOUND, OUTWARD-FACING CONFORMATION
Descriptor:Multidrug resistance protein 1, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Kim, Y.J., Chen, J.
Deposit date:2018-01-02
Release date:2018-01-31
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation.
Science, 359, 2018
6C3O
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CRYO-EM STRUCTURE OF HUMAN KATP BOUND TO ATP AND ADP IN QUATREFOIL FORM
Descriptor:ATP-sensitive inward rectifier potassium channel 11, ATP-binding cassette sub-family C member 8, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lee, K.P.K., Chen, J., MacKinnon, R.
Deposit date:2018-01-10
Release date:2018-01-31
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular structure of human KATP in complex with ATP and ADP
Elife, 6, 2017