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8RSA
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CRYSTAL STRUCTURE OF TWO COVALENT NUCLEOSIDE DERIVATIVES OF RIBONUCLEASE A
Descriptor:RIBONUCLEASE A, 3'-DEOXY-3'-ACETAMIDO-THYMIDINE
Authors:Nachman, J., Wlodawer, A.
Deposit date:1989-08-28
Release date:1991-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of two covalent nucleoside derivatives of ribonuclease A.
Biochemistry, 29, 1990
9RSA
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CRYSTAL STRUCTURE OF TWO COVALENT NUCLEOSIDE DERIVATIVES OF RIBONUCLEASE A
Descriptor:RIBONUCLEASE A, 3'-DEOXY-3'-ACETAMIDO-URIDINE
Authors:Nachman, J., Wlodawer, A.
Deposit date:1989-08-28
Release date:1991-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of two covalent nucleoside derivatives of ribonuclease A.
Biochemistry, 29, 1990
1PGT
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH S-HEXYLGLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Ji, X.
Deposit date:1997-02-17
Release date:1997-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase.
Biochemistry, 36, 1997
2PGT
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE
Descriptor:GLUTATHIONE S-TRANSFERASE, SULFATE ION, (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE, ...
Authors:Ji, X.
Deposit date:1997-02-17
Release date:1997-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase.
Biochemistry, 36, 1997
1SPB
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SUBTILISIN BPN' PROSEGMENT (77 RESIDUES) COMPLEXED WITH A MUTANT SUBTILISIN BPN' (266 RESIDUES). CRYSTAL PH 4.6. CRYSTALLIZATION TEMPERATURE 20 C DIFFRACTION TEMPERATURE-160 C
Descriptor:SUBTILISIN BPN' PROSEGMENT, SUBTILISIN BPN', SODIUM ION
Authors:Gallagher, D.T., Gilliland, G.L., Wang, L., Bryan, P.N.
Deposit date:1995-06-21
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'.
Structure, 3, 1995
3L5W
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL-13 AND C836 FAB
Descriptor:C836 LIGHT CHAIN, C836 HEAVY CHAIN, Interleukin-13, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2009-12-22
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human framework adaptation of a mouse anti-human IL-13 antibody.
J.Mol.Biol., 398, 2010
3L5X
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL-13 AND H2L6 FAB
Descriptor:H2L6 LIGHT CHAIN, H2L6 HEAVY CHAIN, Interleukin-13, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2009-12-22
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human framework adaptation of a mouse anti-human IL-13 antibody.
J.Mol.Biol., 398, 2010
3L7E
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CRYSTAL STRUCTURE OF ANTI-IL-13 ANTIBODY C836
Descriptor:C836 LIGHT CHAIN, C836 HEAVY CHAIN, SULFATE ION, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2009-12-28
Release date:2010-11-10
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Antigen recognition by antibody C836 through adjustment of VL/VH packing
Acta Crystallogr.,Sect.F, 67, 2011
3L7F
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STRUCTURE OF IL-13 ANTIBODY H2L6, A HUMANIZED VARIANT OF C836
Descriptor:H2L6 LIGHT CHAIN, H2L6 HEAVY CHAIN, SULFATE ION, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2009-12-28
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human framework adaptation of a mouse anti-human IL-13 antibody.
J.Mol.Biol., 398, 2010
3TES
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CRYSTAL STRUCTURE OF TENCON
Descriptor:Tencon
Authors:Luo, J., Jacobs, S., Teplyakov, A., Obmolova, G., O'Neil, K., Gilliland, G.
Deposit date:2011-08-15
Release date:2012-05-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of novel FN3 domains with high stability by a consensus sequence approach.
Protein Eng.Des.Sel., 25, 2012
3TEU
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CRYSTAL STRUCTURE OF FIBCON
Descriptor:Fibcon, 1,4-DIETHYLENE DIOXIDE
Authors:Luo, J., Jacobs, S., Teplyakov, A., Obmolova, G., O'Neil, K., Gilliland, G.
Deposit date:2011-08-15
Release date:2012-05-16
Method:X-RAY DIFFRACTION (1.002 Å)
Cite:Design of novel FN3 domains with high stability by a consensus sequence approach.
Protein Eng.Des.Sel., 25, 2012
4DN3
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CRYSTAL STRUCTURE OF ANTI-MCP-1 ANTIBODY CNTO888
Descriptor:CNTO888 LIGHT CHAIN, CNTO888 HEAVY CHAIN
Authors:Obmolova, G., Teplyakov, A., Malia, T., Grygiel, T., Sweet, R., Snyder, L., Gilliland, G.
Deposit date:2012-02-08
Release date:2012-10-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888.
Mol.Immunol., 51, 2012
4DN4
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CNTO888 FAB AND MCP-1 MUTANT P8A
Descriptor:CNTO888 LIGHT CHAIN, CNTO888 HEAVY CHAIN, C-C motif chemokine 2, ...
Authors:Obmolova, G., Teplyakov, A., Malia, T., Grygiel, T., Sweet, R., Snyder, L., Gilliland, G.
Deposit date:2012-02-08
Release date:2012-10-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888.
Mol.Immunol., 51, 2012
4HAF
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CRYSTAL STRUCTURE OF FC-FRAGMENT OF HUMAN IGG2 ANTIBODY (PRIMITIVE CRYSTAL FORM)
Descriptor:Ig gamma-2 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Teplyakov, A., Malia, T., Obmolova, G., Zhao, Y., Gilliland, G.
Deposit date:2012-09-26
Release date:2013-06-12
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface.
Mol.Immunol., 56, 2013
4HAG
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CRYSTAL STRUCTURE OF FC-FRAGMENT OF HUMAN IGG2 ANTIBODY (CENTERED CRYSTAL FORM)
Descriptor:Ig gamma-2 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Teplyakov, A., Malia, T., Obmolova, G., Zhao, Y., Gilliland, G.
Deposit date:2012-09-26
Release date:2013-06-12
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface.
Mol.Immunol., 56, 2013
4PS4
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL-13 AND M1295 FAB
Descriptor:M1295 LIGHT CHAIN, M1295 HEAVY CHAIN, Interleukin-13
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2014-03-06
Release date:2014-03-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Framework Adaptation of a Mouse Anti-Human Il-13 Antibody.
J.Mol.Biol., 398, 2010
5KNG
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CRYSTAL STRUCTURE OF ANTI-IL-13 DARPIN 6G9
Descriptor:DARPIN 6G9, PHOSPHATE ION, GLYCEROL
Authors:Teplyakov, A., Malia, T., Obmolova, G., Gilliland, G.
Deposit date:2016-06-28
Release date:2016-12-14
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Conformational flexibility of an anti-IL-13 DARPin.
Protein Eng. Des. Sel., 30, 2017
5KNH
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CRYSTAL STRUCTURE OF DARPIN 6G9 IN COMPLEX WITH CYNO IL-13
Descriptor:DARPIN 6G9, IL13, ACETATE ION
Authors:Teplyakov, A., Malia, T., Obmolova, G., Gilliland, G.
Deposit date:2016-06-28
Release date:2016-12-14
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Conformational flexibility of an anti-IL-13 DARPin.
Protein Eng. Des. Sel., 30, 2017
5L2H
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CRYSTAL STRUCTURE OF W26A MUTANT OF ANTI-EGFR CENTYRIN P54AR4-83V2
Descriptor:Centyrin, GLYCEROL
Authors:Cardoso, R.M.F., Goldberg, S.D., O Neil, K.T., Gilliland, G.L.
Deposit date:2016-08-01
Release date:2016-11-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8013 Å)
Cite:Engineering a targeted delivery platform using Centyrins.
Protein Eng. Des. Sel., 29, 2016
1APB
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A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
Descriptor:L-ARABINOSE-BINDING PROTEIN, ALPHA-D-FUCOSE, BETA-D-FUCOSE
Authors:Vermersch, P.S., Tesmer, J.J.G., Quiocho, F.A.
Deposit date:1991-11-15
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
1BAP
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A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
Descriptor:L-ARABINOSE-BINDING PROTEIN, ALPHA-L-ARABINOSE, BETA-L-ARABINOSE
Authors:Vermersch, P.S., Tesmer, J.J.G., Quiocho, F.A.
Deposit date:1991-11-15
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
6ABP
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SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES OF AN ARABINOSE-BINDING PROTEIN MUTANT (MET108LEU) WHICH EXHIBITS ENHANCED AFFINITY AND ALTERED SPECIFICITY
Descriptor:L-ARABINOSE-BINDING PROTEIN, ALPHA-L-ARABINOSE, BETA-L-ARABINOSE
Authors:Vermersch, P.S., Tesmer, J.J.G., Quiocho, F.A.
Deposit date:1991-04-25
Release date:1991-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry, 30, 1991
7ABP
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SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES OF AN ARABINOSE-BINDING PROTEIN MUTANT (MET108LEU) WHICH EXHIBITS ENHANCED AFFINITY AND ALTERED SPECIFICITY
Descriptor:L-ARABINOSE-BINDING PROTEIN, ALPHA-D-FUCOSE, BETA-D-FUCOSE
Authors:Vermersch, P.S., Tesmer, J.J.G., Quiocho, F.A.
Deposit date:1991-04-25
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry, 30, 1991
8ABP
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SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES OF AN ARABINOSE-BINDING PROTEIN MUTANT (MET108LEU) WHICH EXHIBITS ENHANCED AFFINITY AND ALTERED SPECIFICITY
Descriptor:L-ARABINOSE-BINDING PROTEIN, ALPHA D-GALACTOSE, BETA-D-GALACTOSE
Authors:Vermersch, P.S., Tesmer, J.J.G., Quiocho, F.A.
Deposit date:1991-04-25
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry, 30, 1991
9ABP
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A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
Descriptor:L-ARABINOSE-BINDING PROTEIN, ALPHA D-GALACTOSE, BETA-D-GALACTOSE
Authors:Vermersch, P.S., Tesmer, J.J.G., Quiocho, F.A.
Deposit date:1991-11-15
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990