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3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, PHENOL, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
1OLC
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OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH LYS-LYS-LYS-ALA
分子名称:OLIGO-PEPTIDE BINDING PROTEIN, LYS-LYS-LYS-ALA, URANYL (VI) ION
著者Tame, J., Wilkinson, A.J.
登録日1995-09-10
公開日1996-01-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands.
Structure, 3, 1995
1PNK
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PENICILLIN ACYLASE HAS A SINGLE-AMINO-ACID CATALYTIC CENTRE
分子名称:PENICILLIN AMIDOHYDROLASE, CALCIUM ION
著者Duggleby, H.J., Moody, P.C.E.
登録日1995-03-16
公開日1996-03-16
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Penicillin acylase has a single-amino-acid catalytic centre.
Nature, 373, 1995
1PNL
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PENICILLIN ACYLASE HAS A SINGLE-AMINO-ACID CATALYTIC CENTRE
分子名称:PENICILLIN AMIDOHYDROLASE, CALCIUM ION, 2-PHENYLACETIC ACID
著者Duggleby, H.J., Moody, P.C.E.
登録日1995-03-16
公開日1996-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Penicillin acylase has a single-amino-acid catalytic centre.
Nature, 373, 1995
1PNM
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PENICILLIN ACYLASE HAS A SINGLE-AMINO-ACID CATALYTIC CENTRE
分子名称:PENICILLIN AMIDOHYDROLASE, CALCIUM ION, phenylmethanesulfonic acid
著者Duggleby, H.J., Moody, P.C.E.
登録日1995-03-16
公開日1996-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Penicillin acylase has a single-amino-acid catalytic centre.
Nature, 373, 1995
2OLB
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OLIGOPEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH TRI-LYSINE
分子名称:OLIGO-PEPTIDE BINDING PROTEIN, TRIPEPTIDE LYS-LYS-LYS, URANYL (VI) ION, ...
著者Tame, J., Wilkinson, A.J.
登録日1995-09-10
公開日1996-01-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands.
Structure, 3, 1995
3FQ9
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DESIGN OF AN INSULIN ANALOG WITH ENHANCED RECEPTOR-BINDING SELECTIVITY. RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
分子名称:Insulin, ZINC ION
著者Zhao, M., Wan, Z.L., Whittaker, L., Xu, B., Phillips, N., Katsoyannis, P., Whittaker, J., Weiss, M.A.
登録日2009-01-07
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
4TGL
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CATALYSIS AT THE INTERFACE: THE ANATOMY OF A CONFORMATIONAL CHANGE IN A TRIGLYCERIDE LIPASE
分子名称:TRIACYL-GLYCEROL ACYLHYDROLASE, DIETHYL PHOSPHONATE
著者Derewenda, U., Brzozowski, A.M., Lawson, D., Derewenda, Z.S.
登録日1991-07-29
公開日1993-07-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase.
Biochemistry, 31, 1992
1GDI
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CRYSTAL STRUCTURE OF FERRIC COMPLEXES OF THE YELLOW LUPIN LEGHEMOGLOBIN WITH ISOQUINOLINE AT 1.8 ANGSTROMS RESOLUTION (RUSSIAN)
分子名称:LEGHEMOGLOBIN (CARBONMONOXY), PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
著者Harutyunyan, E., Safonova, T., Kuranova, I.
登録日1994-09-14
公開日1995-02-27
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The binding of carbon monoxide and nitric oxide to leghaemoglobin in comparison with other haemoglobins.
J.Mol.Biol., 264, 1996
1GDJ
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CRYSTAL STRUCTURE OF FERRIC COMPLEXES OF THE YELLOW LUPIN LEGHEMOGLOBIN WITH ISOQUINOLINE AT 1.8 ANGSTROMS RESOLUTION (RUSSIAN)
分子名称:LEGHEMOGLOBIN (DEOXY), PROTOPORPHYRIN IX CONTAINING FE
著者Harutyunyan, E., Safonova, T., Kuranova, I.
登録日1994-09-14
公開日1995-02-27
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Structure of Deoxy- and Oxy-Leghaemoglobin from Lupin
J.Mol.Biol., 251, 1995
1GDL
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CRYSTAL STRUCTURE OF FERRIC COMPLEXES OF THE YELLOW LUPIN LEGHEMOGLOBIN WITH ISOQUINOLINE AT 1.8 ANGSTROMS RESOLUTION (RUSSIAN)
分子名称:LEGHEMOGLOBIN (NITROGEN MONOXY), PROTOPORPHYRIN IX CONTAINING FE, NITRIC OXIDE
著者Harutyunyan, E., Safonova, T., Kuranova, I.
登録日1994-09-14
公開日1995-02-27
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The binding of carbon monoxide and nitric oxide to leghaemoglobin in comparison with other haemoglobins.
J.Mol.Biol., 264, 1996
1RFE
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CRYSTAL STRUCTURE OF CONSERVED HYPOTHETICAL PROTEIN RV2991 FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:hypothetical protein Rv2991
著者Benini, S., Haouz, A., Proux, F., Betton, J.M., Alzari, P., Dodson, G.G., Wilson, K.S., TB Structural Genomics Consortium (TBSGC)
登録日2003-11-08
公開日2004-12-28
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F420binding protein with unknown function.
J. Struct. Biol., 2019
1TIA
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AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES
分子名称:LIPASE
著者Derewenda, U., Swenson, L., Yamaguchi, S., Wei, Y., Derewenda, Z.S.
登録日1993-12-06
公開日1995-01-26
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献An unusual buried polar cluster in a family of fungal lipases.
Nat.Struct.Biol., 1, 1994
2RBI
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STRUCTURE OF BINASE MUTANT HIS 101 ASN
分子名称:RIBONUCLEASE
著者Offen, W.A., Okorokov, A.L.
登録日1996-11-12
公開日1997-03-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献RNA cleavage without hydrolysis. Splitting the catalytic activities of binase with Asn101 and Thr101 mutations.
Protein Eng., 10, 1997
2RJI
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MALARIAL EBA-175 REGION VI CRYSTALLOGRAPHIC STRUCTURE REVEALS A KIX-LIKE BINDING INTERFACE
分子名称:Erythrocyte binding antigen 175, CALCIUM ION
著者Withers-Martinez, C., Blackman, M.J.
登録日2007-10-15
公開日2007-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Malarial EBA-175 Region VI Crystallographic Structure Reveals a KIX-Like Binding Interface
J.Mol.Biol., 375, 2008
2TPL
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TYROSINE PHENOL-LYASE FROM CITROBACTER INTERMEDIUS COMPLEX WITH 3-(4'-HYDROXYPHENYL)PROPIONIC ACID, PYRIDOXAL-5'-PHOSPHATE AND CS+ ION
分子名称:TYROSINE PHENOL-LYASE, CESIUM ION, HYDROXYPHENYL PROPIONIC ACID
著者Antson, A.A., Demidkina, T.V., Wilson, K.S.
登録日1997-01-23
公開日1997-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity.
Biochemistry, 36, 1997
3W11
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HUMAN INSULIN, ALPHA-CT PEPTIDE(704-719) AND FAB 83-7
分子名称:Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ...
著者Lawrence, M.C., Smith, B.J.
登録日2012-11-06
公開日2013-01-09
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HIGH-AFFINITY INSULIN ANALOGUE [D-PRO-B26]-DTI-NH2, ALPHA-CT PEPTIDE(704-719) AND FAB 83-7
分子名称:Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ...
著者Lawrence, M.C., Smith, B.J., Brzozowsk, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (4.301 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HIGH-AFFINITY INSULIN ANALOGUE [D-PRO-B26]-DTI-NH2, ALPHACT PEPTIDE(693-719) AND FAB 83-7
分子名称:Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ...
著者Lawrence, M.C., Smith, B.J., Brzozowski, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (4.303 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
4LVN
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CRYSTAL STRUCTURE OF PFSUB1-PRODOMAIN-NIMP.M7 FAB COMPLEX
分子名称:Subtilisin-like serine protease, NIMP.M7 Fab light chain, NIMP.M7 Fab heavy chain, ...
著者Withers-Martinez, C., Blackman, M.J.
登録日2013-07-26
公開日2014-05-07
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nat Commun, 5, 2014
4LVO
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CRYSTAL STRUCTURE OF PFSUB1-PRODOMAIN-NIMP.M7 FAB COMPLEX WITH ADDED CACL2
分子名称:Subtilisin-like serine protease, NIMP.M7 Fab light chain, NIMP.M7 Fab heavy chain, ...
著者Withers-Martinez, C., Blackman, M.J.
登録日2013-07-26
公開日2014-05-07
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nat Commun, 5, 2014
5IQP
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14-3-3 PROTEIN TAU ISOFORM
分子名称:14-3-3 protein theta, SULFATE ION
著者Xiao, B., Smerdon, S.J., Gamblin, S.J.
登録日2016-03-11
公開日2016-03-23
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
5KQV
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INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1,CR,L2, FNIII-1 AND ALPHACT PEPTIDE IN COMPLEX WITH BOVINE INSULIN AND FAB 83-14 (REVISED STRUCTURE)
分子名称:Insulin, MONOCLONAL ANTIBODY FAB 83-14 - HEAVY CHAIN, MONOCLONAL ANTIBODY FAB 83-14 - LIGHT CHAIN, ...
著者Lawrence, M.C., Smith, B.J., Croll, T.I.
登録日2016-07-06
公開日2017-07-19
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (4.4 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
1B05
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STRUCTURE OF OLIGO-PEPTIDE BINDING PROTEIN COMPLEXED WITH LYS-CYS-LYS
分子名称:PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN, PEPTIDE LYS-CYS-LYS, URANIUM ATOM
著者Tame, J.R.H., Wilkinson, A.J.
登録日1998-11-20
公開日1998-11-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystallographic and calorimetric analysis of peptide binding to OppA protein.
J.Mol.Biol., 291, 1999
1B32
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OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KMK
分子名称:PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN), PROTEIN (LYS-MET-LYS), URANYL (VI) ION, ...
著者Tame, J.R.H., Wilkinson, A.J.
登録日1998-12-15
公開日1998-12-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystallographic and calorimetric analysis of peptide binding to OppA protein.
J.Mol.Biol., 291, 1999