Author results

5Z5U
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THE FIRST BROMODOMAIN OF BRD4 WITH COMPOUND BDF-2254
Descriptor:Bromodomain-containing protein 4, 2-amino-4-(1H-imidazol-1-yl)quinoline-6,8-diol
Authors:Zhang, H., Luo, C.
Deposit date:2018-01-20
Release date:2019-01-23
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.631 Å)
Cite:Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.
Oncogenesis, 7, 2018
5Z5V
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THE FIRST BROMODOMAIN OF BRD4 WITH COMPOUND BDF-1253
Descriptor:Bromodomain-containing protein 4, N-{8-hydroxy-4-[(1H-imidazol-1-yl)methyl]quinolin-2-yl}acetamide
Authors:Zhang, H., Luo, C.
Deposit date:2018-01-20
Release date:2019-01-23
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.
Oncogenesis, 7, 2018
3ROK
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-27
Descriptor:ADP-ribosyl cyclase 1, 5-O-[(S)-butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-alpha-D-arabinofuranose
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROM
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-48
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-thiophosphono-alpha-D-arabinofuranose
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROP
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-50B
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-ribofuranose, NICOTINAMIDE
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROQ
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-46
Descriptor:ADP-ribosyl cyclase 1, (2R,3R,4S,5S)-4-fluoro-3,5-dihydroxytetrahydrofuran-2-yl 2-phenylethyl hydrogen (S)-phosphate
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
5F1K
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HUMAN CD38 IN COMPLEX WITH NANOBODY MU1053
Descriptor:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU1053
Authors:Zhang, H., Hao, Q.
Deposit date:2015-11-30
Release date:2016-06-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Immuno-targeting the multifunctional CD38 using nanobody
Sci Rep, 6, 2016
5F1O
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HUMAN CD38 IN COMPLEX WITH NANOBODY MU551
Descriptor:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU551
Authors:Zhang, H., Hao, Q.
Deposit date:2015-11-30
Release date:2016-06-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Immuno-targeting the multifunctional CD38 using nanobody
Sci Rep, 6, 2016
5XP6
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NATIVE STRUCTURE OF NDM-1 CRYSTALLIZED AT PH5.5
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
Authors:Zhang, H., Ma, G., Lai, J., Sun, H.
Deposit date:2017-06-01
Release date:2018-03-07
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors
Nat Commun, 9, 2018
5XP9
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CRYSTAL STRUCTURE OF BISMUTH BOUND NDM-1
Descriptor:Metallo-beta-lactamase type 2, Bismuth(III) ION, GLYCEROL
Authors:Zhang, H., Ma, G., Lai, T.P., Sun, H.
Deposit date:2017-06-01
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors
Nat Commun, 9, 2018
5ZV3
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CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-28.1 IN COMPLEX WITH ITS TAU PEPTIDE
Descriptor:Peptide from Microtubule-associated protein tau, Heavy chain of antibody CBTAU28.1, Light chain (kappa) of antibody CBTAU28.1
Authors:Zhang, H., Wilson, I.A.
Deposit date:2018-05-09
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
3CHH
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CRYSTAL STRUCTURE OF DI-IRON AURF
Descriptor:p-Aminobenzoate N-Oxygenase, MU-OXO-DIIRON
Authors:Zhang, H., Brunzelle, J.S., Nair, S.K.
Deposit date:2008-03-09
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3CHI
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CRYSTAL STRUCTURE OF DI-IRON AURF (MONOCLINIC FORM)
Descriptor:p-Aminobenzoate N-Oxygenase, MU-OXO-DIIRON
Authors:Zhang, H., Brunzelle, J.S., Nair, S.K.
Deposit date:2008-03-09
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3CHT
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CRYSTAL STRUCTURE OF DI-IRON AURF WITH PARTIALLY BOUND LIGAND
Descriptor:p-Aminobenzoate N-Oxygenase, MU-OXO-DIIRON, 4-NITROBENZOIC ACID
Authors:Zhang, H., Brunzelle, J.S., Nair, S.K.
Deposit date:2008-03-10
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3CHU
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CRYSTAL STRUCTURE OF DI-IRON AURF
Descriptor:p-Aminobenzoate N-Oxygenase, MU-OXO-DIIRON
Authors:Zhang, H., Brunzelle, J.S., Nair, S.K.
Deposit date:2008-03-10
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EUO
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CRYSTAL STRUCTURE OF A FUNGAL TYPE III POLYKETIDE SYNTHASE, ORAS
Descriptor:Type III Pentaketide Synthase
Authors:Zhang, H., Brunzelle, J.S., Nair, S.K.
Deposit date:2008-10-10
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa.
Chem.Biol., 15, 2008
3EUQ
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X-RAY STRUCTURAL OF A TYPE III PENTAKETIDE SYNTHASE FROM NEUROSPORA CRASSA
Descriptor:Putative uncharacterized protein, HEXAETHYLENE GLYCOL
Authors:Zhang, H., Brunzelle, J.S., Nair, S.K.
Deposit date:2008-10-10
Release date:2008-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa.
Chem.Biol., 15, 2008
3EUT
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X-RAY CRYSTAL STRUCTURE OF A TYPE III PENTAKETIDE SYNTHASE FROM NEUROSPORA CRASSA
Descriptor:Putative uncharacterized protein, icosanoic acid
Authors:Zhang, H., Brunzelle, J.S., Nair, S.K.
Deposit date:2008-10-10
Release date:2008-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa.
Chem.Biol., 15, 2008
4CT1
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HUMAN PDK1-PKCZETA KINASE CHIMERA IN COMPLEX WITH ALLOSTERIC COMPOUND PS315 BOUND TO THE PIF-POCKET
Descriptor:3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, (2Z)-3-(biphenyl-4-yl)-5-(4-chlorophenyl)pent-2-enoic acid, ...
Authors:Schulze, J.O., Zhang, H., Lopez-Garcia, L.A., Biondi, R.M.
Deposit date:2014-03-11
Release date:2014-05-28
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-Terminal Domains and an Allosteric Small Compound.
Chem.Biol., 21, 2014
4CT2
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HUMAN PDK1-PKCZETA KINASE CHIMERA
Descriptor:3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, DITHIANE DIOL, ...
Authors:Schulze, J.O., Zhang, H., Lopez-Garcia, L.A., Biondi, R.M.
Deposit date:2014-03-11
Release date:2014-05-28
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-Terminal Domains and an Allosteric Small Compound.
Chem.Biol., 21, 2014
5TSR
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CRYSTAL STRUCTURE OF PRL-3 PHOSPHATASE IN COMPLEX WITH THE BATEMAN DOMAIN OF CNNM3 MAGNESIUM TRANSPORTER
Descriptor:Protein tyrosine phosphatase type IVA 3, Metal transporter CNNM3
Authors:Kozlov, G., Zhang, H., Gehring, K.
Deposit date:2016-10-31
Release date:2017-02-08
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (3.188 Å)
Cite:PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.
Sci Rep, 7, 2017
5XAF
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-COMPOUND Z1 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhang, H., Luo, C., Wang, Y.
Deposit date:2017-03-12
Release date:2017-12-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
5XAG
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-COMPOUND Z2 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhang, H., Luo, C., Wang, Y.
Deposit date:2017-03-12
Release date:2018-01-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
2W8K
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Y-FAMILY DNA POLYMERASE DPO4 BYPASSING N2-NAPHTHYL-GUANINE ADDUCT IN SYN ORIENTATION
Descriptor:DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*CP*N2GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ...
Authors:Eoff, R.L., Zhang, H., Egli, M., Guengerich, F.P.
Deposit date:2009-01-16
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Versatility of Y-Family Sulfolobus Solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts.
J.Biol.Chem., 284, 2009
2W8L
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Y-FAMILY DNA POLYMERASE DPO4 BYPASSING N2-NAPHTHYL-GUANINE ADDUCT IN ANTI ORIENTATION
Descriptor:DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*CP*N2GP*GP*AP*AP*TP*CP *CP*TP*TP*CP*CP*CP*CP*C)-3', ...
Authors:Eoff, R.L., Zhang, H., Egli, M., Guengerich, F.P.
Deposit date:2009-01-16
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Versatility of Y-Family Sulfolobus Solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts.
J.Biol.Chem., 284, 2009