Author results

3EQF
  • Download 3eqf
  • View 3eqf
Molmil generated image of 3eqf
X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A BINARY COMPLEX WITH K252A AND MG2P
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, K-252A, MAGNESIUM ION, ...
Authors:Fischmann, T.O.
Deposit date:2008-09-30
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQG
  • Download 3eqg
  • View 3eqg
Molmil generated image of 3eqg
X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A TERNARY COMPLEX WITH PD, ADP AND MG2P
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Fischmann, T.O.
Deposit date:2008-09-30
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQH
  • Download 3eqh
  • View 3eqh
Molmil generated image of 3eqh
X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A TERNARY COMPLEX WITH U0126, ADP AND MG2P
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, (2Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Fischmann, T.O.
Deposit date:2008-09-30
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQI
  • Download 3eqi
  • View 3eqi
Molmil generated image of 3eqi
X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A BINARY COMPLEX WITH ADP AND MG2P
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Fischmann, T.O.
Deposit date:2008-09-30
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3P43
  • Download 3p43
  • View 3p43
Molmil generated image of 3p43
STRUCTURE AND ACTIVITIES OF ARCHAEAL MEMBERS OF THE LIGD 3' PHOSPHOESTERASE DNA REPAIR ENZYME SUPERFAMILY
Descriptor:Putative uncharacterized protein, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:Smith, P., Nair, P.A., Das, U., Shuman, S.
Deposit date:2010-10-05
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures and activities of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamily.
Nucleic Acids Res., 39, 2011
4C46
  • Download 4c46
  • View 4c46
Molmil generated image of 4c46
ANDREI-N-LVPAS FUSED TO GCN4 ADAPTORS
Descriptor:GENERAL CONTROL PROTEIN GCN4, BROMIDE ION
Authors:Albrecht, R., Alva, V., Ammelburg, M., Baer, K., Basina, E., Boichenko, I., Bonhoeffer, F., Braun, V., Chaubey, M., Chauhan, N., Chellamuthu, V.R., Coles, M., Deiss, S., Ewers, C.P., Forouzan, D., Fuchs, A., Groemping, Y., Hartmann, M.D., Hernandez Alvarez, B., Jeganantham, A., Kalev, I., Koenninger, U., Koiwai, K., Kopec, K.O., Korycinski, M., Laudenbach, B., Lehmann, K., Leo, J.C., Linke, D., Marialke, J., Martin, J., Mechelke, M., Michalik, M., Noll, A., Patzer, S.I., Scharfenberg, F., Schueckel, M., Shahid, S.A., Sulz, E., Ursinus, A., Wuertenberger, S., Zhu, H.
Deposit date:2013-08-30
Release date:2013-09-11
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Your Personalized Protein Structure: Andrei N. Lupas Fused to GCN4 Adaptors.
J.Struct.Biol., 186, 2014
4CIM
  • Download 4cim
  • View 4cim
Molmil generated image of 4cim
COMPLEX OF A BCL-W BH3 MUTANT WITH A BH3 DOMAIN
Descriptor:BCL-2-LIKE PROTEIN 2, 1,2-ETHANEDIOL
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
4CIN
  • Download 4cin
  • View 4cin
Molmil generated image of 4cin
COMPLEX OF BCL-XL WITH ITS BH3 DOMAIN
Descriptor:BCL-2-LIKE PROTEIN 1, CALCIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
4HVL
  • Download 4hvl
  • View 4hvl
Molmil generated image of 4hvl
STRUCTURE OF A SERINE PROTEASE MYCP1, AN ESSENTIAL COMPONENT OF THE TYPE VII (ESX-1) SECRETION SYSTEM
Descriptor:Membrane-anchored mycosin mycp1, ZINC ION, IMIDAZOLE, ...
Authors:Korotkov, K.V., Evans, T.J.
Deposit date:2012-11-06
Release date:2013-05-08
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.
J.Struct.Biol., 184, 2013
4KG7
  • Download 4kg7
  • View 4kg7
Molmil generated image of 4kg7
STRUCTURE OF MYCP3 PROTEASE FROM THE TYPE VII (ESX-3) SECRETION SYSTEM.
Descriptor:Peptidase S8 and S53, subtilisin, kexin, ...
Authors:Korotkov, K.V., Evans, T.J.
Deposit date:2013-04-28
Release date:2013-06-19
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.
J.Struct.Biol., 184, 2013
4LYN
  • Download 4lyn
  • View 4lyn
Molmil generated image of 4lyn
CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH (2S)-N-(5-(((5-TERT-BUTYL-1,3-OXAZOL-2-YL)METHYL)SULFANYL)-1,3-THIAZOL-2-YL)-2-PHENYLPROPANAMIDE
Descriptor:Cyclin-dependent kinase 2, (2S)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)-2-phenylpropanamide
Authors:Sack, J.S.
Deposit date:2013-07-31
Release date:2013-10-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities
J.Med.Chem., 45, 2002
4RL1
  • Download 4rl1
  • View 4rl1
Molmil generated image of 4rl1
STRUCTURAL AND FUNCTIONAL ANALYSIS OF A LOADING ACYLTRANSFERASE FROM THE AVERMECTIN MODULAR POLYKETIDE SYNTHASE
Descriptor:Type I polyketide synthase AVES 1
Authors:Wang, F., Wang, Y., Zheng, J.
Deposit date:2014-10-15
Release date:2015-01-28
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
Acs Chem.Biol., 10, 2015
4XP8
  • Download 4xp8
  • View 4xp8
Molmil generated image of 4xp8
STRUCTURE OF ETGA D60N MUTANT
Descriptor:EtgA protein
Authors:Burkinshaw, B.J., Worrall, L.J., Strynadka, N.C.J.
Deposit date:2015-01-16
Release date:2015-02-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural Analysis of a Specialized Type III Secretion System Peptidoglycan-cleaving Enzyme.
J.Biol.Chem., 290, 2015
4Z24
  • Download 4z24
  • View 4z24
Molmil generated image of 4z24
MIMIVIRUS R135 (RESIDUES 51-702)
Descriptor:GMC-type oxidoreductase R135, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Klose, T., Rossmann, M.G.
Deposit date:2015-03-28
Release date:2015-04-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Mimivirus Enzyme that Participates in Viral Entry.
Structure, 23, 2015
4Z25
  • Download 4z25
  • View 4z25
Molmil generated image of 4z25
MIMIVIRUS R135 (RESIDUES 51-702)
Descriptor:Putative GMC-type oxidoreductase R135, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Klose, T., Rossmann, M.G.
Deposit date:2015-03-28
Release date:2015-06-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.339 Å)
Cite:A Mimivirus Enzyme that Participates in Viral Entry.
Structure, 23, 2015
4Z26
  • Download 4z26
  • View 4z26
Molmil generated image of 4z26
MIMIVIRUS R135 (RESIDUES 51-702)
Descriptor:Putative GMC-type oxidoreductase R135, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Klose, T., Rossmann, M.G.
Deposit date:2015-03-28
Release date:2015-05-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.915 Å)
Cite:A Mimivirus Enzyme that Participates in Viral Entry.
Structure, 23, 2015
5TEG
  • Download 5teg
  • View 5teg
Molmil generated image of 5teg
CRYSTAL STRUCTURE OF HSETD8 IN COMPLEX WITH HISTONE H4K20 NORLEUCINE MUTANT PEPTIDE AND S-ADENOSYLMETHIONINE
Descriptor:N-lysine methyltransferase KMT5A, Histone H4 mutant peptide with H4K20norleucine, S-ADENOSYLMETHIONINE
Authors:Judge, R.A., Petros, A.M.
Deposit date:2016-09-21
Release date:2016-12-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
ACS Med Chem Lett, 7, 2016
5W3D
  • Download 5w3d
  • View 5w3d
Molmil generated image of 5w3d
THE STRUCTURE OF KINESIN-14 WILD-TYPE NCD-ADP DIMER
Descriptor:Protein claret segregational, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Park, H.W., Ma, Z., Chacko, J., Jiang, S.M., Robinson, R.C., Endow, S.A.
Deposit date:2017-06-07
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
5W8H
  • Download 5w8h
  • View 5w8h
Molmil generated image of 5w8h
CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE A IN COMPLEX WITH INHIBITOR COMPOUND 11
Descriptor:L-lactate dehydrogenase A chain, 2-[3-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ACETATE ION, ...
Authors:Lukacs, C.M., Dranow, D.M.
Deposit date:2017-06-21
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J. Med. Chem., 60, 2017
5W8I
  • Download 5w8i
  • View 5w8i
Molmil generated image of 5w8i
CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE A IN COMPLEX WITH INHIBITOR COMPOUND 23 AND ZINC
Descriptor:L-lactate dehydrogenase A chain, ZINC ION, 2-[3-(3,4-difluorophenyl)-5-hydroxy-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ...
Authors:Lukacs, C.M., Abendroth, J.
Deposit date:2017-06-21
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J. Med. Chem., 60, 2017
5W8J
  • Download 5w8j
  • View 5w8j
Molmil generated image of 5w8j
CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE A IN COMPLEX WITH INHIBITOR COMPOUND 29
Descriptor:L-lactate dehydrogenase A chain, 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, MALONIC ACID, ...
Authors:Lukacs, C.M., Moulin, A.
Deposit date:2017-06-21
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J. Med. Chem., 60, 2017
5W8K
  • Download 5w8k
  • View 5w8k
Molmil generated image of 5w8k
CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE A IN COMPLEX WITH INHIBITOR COMPOUND 29 AND NADH
Descriptor:L-lactate dehydrogenase A chain, 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Lukacs, C.M., Dranow, D.M.
Deposit date:2017-06-21
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J. Med. Chem., 60, 2017
5W8L
  • Download 5w8l
  • View 5w8l
Molmil generated image of 5w8l
CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE A IN COMPLEX WITH INHIBITOR COMPOUND 59 AND NADH
Descriptor:L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-([1,1'-biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, ...
Authors:Davies, D.R., Dranow, D.M.
Deposit date:2017-06-21
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J. Med. Chem., 60, 2017
5YTS
  • Download 5yts
  • View 5yts
Molmil generated image of 5yts
CRYSTAL STRUCTURE OF YB1 COLD-SHOCK DOMAIN IN COMPLEX WITH UCUUCU
Descriptor:Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*CP*UP*UP*C)-3'), SULFATE ION
Authors:Yang, X., Huang, Y.
Deposit date:2017-11-20
Release date:2018-12-05
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 294, 2019
5YTT
  • Download 5ytt
  • View 5ytt
Molmil generated image of 5ytt
CRYSTAL STRUCTURE OF YB1 COLD-SHOCK DOMAIN IN COMPLEX WITH UCAUGU
Descriptor:Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*GP*U)-3'), SULFATE ION
Authors:Yang, X., Huang, Y.
Deposit date:2017-11-20
Release date:2018-12-05
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 294, 2019