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4PYZ
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CRYSTAL STRUCTURE OF THE FIRST TWO UBL DOMAINS OF DEUBIQUITYLASE USP7
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, UNKNOWN ATOM OR ION
Authors:Walker, J.R., Dong, A., Ong, M.S., Dhe-Paganon, S., Kania, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-03-28
Release date:2014-04-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Crystal structure of the first two Ubl domains of Deubiquitylase USP7
to be published
4Z30
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CRYSTAL STRUCTURE OF THE ROQ DOMAIN OF HUMAN ROQUIN-2
Descriptor:Roquin-2, UNKNOWN ATOM OR ION
Authors:DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-03-30
Release date:2015-10-14
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Sci Rep, 5, 2015
4Z31
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CRYSTAL STRUCTURE OF THE RC3H2 ROQ DOMAIN IN COMPLEX WITH STEM-LOOP AND DOUBLE-STRANDED FORMS OF RNA
Descriptor:Roquin-2, RNA (5'-R(*A)-D(P*UP*GP*UP*UP*CP*UP*GP*UP*GP*AP*AP*CP*AP*C)-3'), UNKNOWN ATOM OR ION, ...
Authors:DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-03-30
Release date:2015-10-14
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Sci Rep, 5, 2015
5H9M
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CRYSTAL STRUCTURE OF SIAH2 SBD DOMAIN
Descriptor:E3 ubiquitin-protein ligase SIAH2, ZINC ION, CHLORIDE ION, ...
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-12-28
Release date:2016-02-17
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Crystal structure of siah2 SBD domain
to be published
5JJW
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CRYSTAL STRUCTURE OF THE HAT DOMAIN OF SART3 IN COMPLEX WITH USP15 DUSP-UBL DOMAIN
Descriptor:Squamous cell carcinoma antigen recognized by T-cells 3, Ubiquitin carboxyl-terminal hydrolase 15, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
to be published
5JJX
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CRYSTAL STRUCTURE OF THE HAT DOMAIN OF SART3
Descriptor:Squamous cell carcinoma antigen recognized by T-cells 3, CHLORIDE ION, UNKNOWN ATOM OR ION
Authors:DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the HAT domain of sart3
to be published
5ULO
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CRYSTAL STRUCTURE OF 14-3-3 ZETA IN COMPLEX WITH A SERINE 124-PHOSPHORYLATED TBC1D7 PEPTIDE
Descriptor:14-3-3 protein zeta/delta, TBC1 domain family member 7, 1,2-ETHANEDIOL, ...
Authors:DONG, A., HU, J., MADIGAN, J., WALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
6MIW
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WWE DOMAIN OF HUMAN HUWE1
Descriptor:E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Halabelian, L., Loppnau, P., Tempel, W., Wong, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-09-20
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:WWE domain of human HUWE1
To Be Published
2E9N
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STRUCTURE OF H-CHK1 COMPLEXED WITH A767085
Descriptor:Serine/threonine-protein kinase Chk1, 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
2E9O
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STRUCTURE OF H-CHK1 COMPLEXED WITH AA582939
Descriptor:Serine/threonine-protein kinase Chk1, 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
2E9P
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STRUCTURE OF H-CHK1 COMPLEXED WITH A771129
Descriptor:Serine/threonine-protein kinase Chk1, 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design, Synthesis and Biological Evaluation of Potent and Selective Macrocyclic Chk1 Inhibitors
To be Published
2E9U
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STRUCTURE OF H-CHK1 COMPLEXED WITH A780125
Descriptor:Serine/threonine-protein kinase Chk1, 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
Authors:Park, C.
Deposit date:2007-01-27
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors
To be Published
2E9V
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STRUCTURE OF H-CHK1 COMPLEXED WITH A859017
Descriptor:Serine/threonine-protein kinase Chk1, 18-CHLORO-2-OXO-17-[(PYRIDIN-4-YLMETHYL)AMINO]-2,3,11,12,13,14-HEXAHYDRO-1H,10H-4,8-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECINE-7-CARBONITRILE
Authors:Park, C.
Deposit date:2007-01-27
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors
To be Published
6E40
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CRYSTAL STRUCTURE OF THE INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEXED WITH FERRIC HEME AND EPACADOSTAT
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E41
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERRIC HEME AND AN EPACADOSTAT ANALOG
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]sulfanyl}-1,2,5-oxadiazole-3-carboximidamide
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E42
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERRIC HEME AND 4-CHLOROPHENYL IMIDAZOLE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-(3-chlorophenyl)-1H-imidazole, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E43
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH A BMS-978587 ANALOG
Descriptor:Indoleamine 2,3-dioxygenase 1, (1R,2S)-2-(4-[cyclohexyl(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, BENZOIC ACID
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E44
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) FREE ENZYME IN THE FERRIC STATE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, PHOSPHATE ION
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E45
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) FREE ENZYME IN THE FERROUS STATE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E46
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERROUS HEME AND TRYPTOPHAN
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
2PZ9
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CRYSTAL STRUCTURE OF PUTATIVE TRANSCRIPTIONAL REGULATOR SCO4942 FROM STREPTOMYCES COELICOLOR
Descriptor:Putative regulatory protein, SULFATE ION
Authors:Filippova, E.V., Chruszcz, M., Xu, X., Zheng, H., Cymborowski, M., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-17
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:In situ proteolysis for protein crystallization and structure determination.
Nat.Methods, 4, 2007
5WRV
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COMPLEX STRUCTURE OF HUMAN SRP72/SRP68
Descriptor:Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72, ACETATE ION, ...
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5WRW
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STRUCTURE OF HUMAN APO-SRP72
Descriptor:Signal recognition particle subunit SRP72, SULFATE ION
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5YYL
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STRUCTURE OF MAJOR ROYAL JELLY PROTEIN 1 OLIGOMER
Descriptor:Major royal jelly protein 1, Apisimin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Tian, W., Chen, Z.
Deposit date:2017-12-10
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun, 9, 2018
4NRM
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 IN COMPLEX WITH CITRATE AND ACETATE
Descriptor:RNA demethylase ALKBH5, CITRATE ANION, ACETATE ION
Authors:Feng, C., Chen, Z., Liu, Y.
Deposit date:2013-11-27
Release date:2014-03-19
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289, 2014