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2SOD
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BU of 2sod by Molmil
DETERMINATION AND ANALYSIS OF THE 2 ANGSTROM STRUCTURE OF COPPER, ZINC SUPEROXIDE DISMUTASE
Descriptor: COPPER (II) ION, COPPER,ZINC SUPEROXIDE DISMUTASE, ZINC ION
Authors:Tainer, J.A, Getzoff, E.D, Richardson, J.S, Richardson, D.C.
Deposit date:1980-03-25
Release date:1980-05-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase.
J.Mol.Biol., 160, 1982
1AKZ
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BU of 1akz by Molmil
HUMAN URACIL-DNA GLYCOSYLASE
Descriptor: URACIL-DNA GLYCOSYLASE
Authors:Tainer, J.A, Mol, C.D.
Deposit date:1997-05-27
Release date:1997-08-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
Embo J., 17, 1998
7KG3
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BU of 7kg3 by Molmil
Crystal structure of CoV-2 Nsp3 Macrodomain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MALONATE ION, ...
Authors:Arvai, A, Brosey, C.A, Link, T, Jones, D.E, Ahmed, Z, Tainer, J.A.
Deposit date:2020-10-15
Release date:2020-10-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Prog.Biophys.Mol.Biol., 163, 2021
1AP6
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BU of 1ap6 by Molmil
TYR34->PHE MUTANT OF HUMAN MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE
Descriptor: MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE
Authors:Guan, Y, Tainer, J.A.
Deposit date:1997-07-24
Release date:1998-01-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.
Biochemistry, 37, 1998
1BIX
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BU of 1bix by Molmil
THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES
Descriptor: AP ENDONUCLEASE 1, PLATINUM (II) ION, SAMARIUM (III) ION
Authors:Gorman, M.A, Morera, S, Rothwell, D.G, De La Fortelle, E, Mol, C.D, Tainer, J.A, Hickson, I.D, Freemont, P.S.
Deposit date:1998-06-19
Release date:1999-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
EMBO J., 16, 1997
1BUH
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BU of 1buh by Molmil
CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1
Descriptor: PROTEIN (CDK2 HUMAN), PROTEIN (CKSHS1 HUMAN)
Authors:Bourne, Y, Tainer, J.A.
Deposit date:1998-09-03
Release date:1998-09-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Cell(Cambridge,Mass.), 84, 1996
8GJA
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BU of 8gja by Molmil
RAD51C-XRCC3 structure
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, RAD51C, ...
Authors:Arvai, A.S, Tainer, J.A, Williams, G, Longo, M.A.
Deposit date:2023-03-15
Release date:2023-08-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.
Nat Commun, 14, 2023
8GJ9
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BU of 8gj9 by Molmil
RAD51C N-terminal domain
Descriptor: RAD51C, ZINC ION
Authors:Arvai, A.S, Tainer, J.A, Williams, G.
Deposit date:2023-03-15
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.
Nat Commun, 14, 2023
8GJ8
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BU of 8gj8 by Molmil
RAD51C C-terminal domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAD51C
Authors:Arvai, A.S, Tainer, J.A, Williams, G.
Deposit date:2023-03-15
Release date:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.
Nat Commun, 14, 2023
5K97
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BU of 5k97 by Molmil
Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2016-05-31
Release date:2017-06-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5KSE
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BU of 5kse by Molmil
Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2016-07-08
Release date:2017-06-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5UM9
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BU of 5um9 by Molmil
Flap endonuclease 1 (FEN1) D86N with 5'-flap substrate DNA and Sm3+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2017-01-26
Release date:2017-06-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
7N8V
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BU of 7n8v by Molmil
Crystal structure of free ERI2 nuclease
Descriptor: ERI1 exoribonuclease 2, SULFATE ION
Authors:Thapar, R, Arvai, A.S, Tainer, J.A.
Deposit date:2021-06-15
Release date:2022-07-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of free ERI2 nuclease
To Be Published
7N8W
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BU of 7n8w by Molmil
Crystal structure of ERI2 nuclease bound to rAMP
Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, ERI1 exoribonuclease 2, ...
Authors:Thapar, R, Arvai, A.S, Tainer, J.A.
Deposit date:2021-06-15
Release date:2022-07-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of ERI2 nuclease bound to rAMP
To Be Published
4SKN
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BU of 4skn by Molmil
A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA
Descriptor: DNA (5'-D(*AP*AP*AP*GP*CP*CP*GP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*(D1P)P*GP*GP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE), ...
Authors:Slupphaug, G, Mol, C.D, Kavli, B, Arvai, A.S, Krokan, H.E, Tainer, J.A.
Deposit date:1999-02-20
Release date:1999-02-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature, 384, 1996
4TWS
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BU of 4tws by Molmil
Gadolinium Derivative of Tetragonal Hen Egg-White Lysozyme at 1.45 A Resolution
Descriptor: 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, CHLORIDE ION, GADOLINIUM ATOM, ...
Authors:Holton, J.M, Classen, S, Frankel, K.A, Tainer, J.A.
Deposit date:2014-07-01
Release date:2014-08-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures.
Febs J., 281, 2014
6VBH
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BU of 6vbh by Molmil
Human XPG endonuclease catalytic domain
Descriptor: DNA repair protein complementing XP-G cells,Flap endonuclease 1, SULFATE ION
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2019-12-18
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VBA
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BU of 6vba by Molmil
Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA)
Descriptor: 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid), Uracil-DNA glycosylase
Authors:Moiani, D, Arvai, A.S, Tainer, J.A.
Deposit date:2019-12-18
Release date:2021-03-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Prog.Biophys.Mol.Biol., 163, 2021
6O9X
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BU of 6o9x by Molmil
Structure of human PARG complexed with JA2-4
Descriptor: 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA1
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BU of 6oa1 by Molmil
Structure of human PARG complexed with JA2120
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6PBK
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BU of 6pbk by Molmil
Archaellum periplasmic stator protein complex FlaF and FlaG from Sulfolobus acidocaldarius
Descriptor: 1,2-ETHANEDIOL, Conserved flagellar protein F, DI(HYDROXYETHYL)ETHER, ...
Authors:Tsai, C.-L, Tainer, J.A.
Deposit date:2019-06-14
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility.
Nat Microbiol, 5, 2020
8D3I
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BU of 8d3i by Molmil
Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with quinolin-4-amine
Descriptor: 1,2-ETHANEDIOL, Apoptosis-inducing factor 1, mitochondrial, ...
Authors:Brosey, C.A, Tainer, J.A.
Deposit date:2022-06-01
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
To Be Published
8D3J
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BU of 8d3j by Molmil
Crystal structure of human Apoptosis-Inducing Factor (AIF) complexed with 6-fluoro-2-methylquinolin-4-amine
Descriptor: 1,2-ETHANEDIOL, 6-fluoro-2-methylquinolin-4-amine, Apoptosis-inducing factor 1, ...
Authors:Brosey, C.A, Tainer, J.A.
Deposit date:2022-06-01
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
To Be Published
8D3G
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BU of 8d3g by Molmil
Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with 6-chloroquinolin-4-amine
Descriptor: 1,2-ETHANEDIOL, 6-chloroquinolin-4-amine, Apoptosis-inducing factor 1, ...
Authors:Brosey, C.A, Tainer, J.A.
Deposit date:2022-06-01
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
To Be Published
8D3K
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BU of 8d3k by Molmil
Crystal structure of human Apoptosis-Inducing Factor (AIF) complexed with 8-fluoro-2-methylquinolin-4-amine
Descriptor: 1,2-ETHANEDIOL, 8-fluoro-2-methylquinolin-4-amine, Apoptosis-inducing factor 1, ...
Authors:Brosey, C.A, Tainer, J.A.
Deposit date:2022-06-01
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
To Be Published

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