Author results

3UJI
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CRYSTAL STRUCTURE OF ANTI-HIV-1 V3 FAB 2558 IN COMPLEX WITH MN PEPTIDE
Descriptor:Light chain of anti-HIV-1 V3 monoclonal antibody 2558, Fab region of the heavy chain of anti-HIV-1 V3 monoclonal antibody 2558, Envelope glycoprotein gp160, ...
Authors:Kong, X.P.
Deposit date:2011-11-07
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure.
Plos One, 6, 2011
3UJJ
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CRYSTAL STRUCTURE OF ANTI-HIV-1 V3 FAB 4025 IN COMPLEX WITH CON A PEPTIDE
Descriptor:Light chain of anti-HIV-1 V3 monoclonal antibody 4025, Fab region of the heavy chain of anti-HIV-1 V3 monoclonal antibody 4025, Gp120, ...
Authors:Kong, X.P., Sampson, J.
Deposit date:2011-11-07
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure.
Plos One, 6, 2011
4F9E
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CYCLIC DI-GMP SENSING VIA THE INNATE IMMUNE SIGNALING PROTEIN STING
Descriptor:Transmembrane protein 173
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
4F9G
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CRYSTAL STRUCTURE OF STING COMPLEX WITH CYCLIC DI-GMP.
Descriptor:Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
4FDL
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CRYSTAL STRUCTURE OF CASPASE-7
Descriptor:Caspase-7
Authors:Kabaleeswaran, V.
Deposit date:2012-05-28
Release date:2012-08-01
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:A class of allosteric caspase inhibitors identified by high-throughput screening.
Mol.Cell, 47, 2012
4FEA
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CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:Caspase-7, chloro{methyl hydrogenato(3-)-kappa~2~N,S [pyridin-2-yl(pyridin-2(1H)-ylidene-kappaN)methyl]carbonodithiohydrazonate}copper
Authors:Kabaleeswaran, V.
Deposit date:2012-05-29
Release date:2012-08-01
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (3.79 Å)
Cite:A class of allosteric caspase inhibitors identified by high-throughput screening.
Mol.Cell, 47, 2012
4PY4
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CRYSTAL STRUCTURE OF HUMAN POLY(ADP-RIBOSE) POLYMERASE 14, CATALYTIC DOMAIN IN COMPLEX WITH AN INHIBITOR XL2
Descriptor:Poly [ADP-ribose] polymerase 14, 2-({4-[(1R)-1-(dimethylamino)ethyl]phenyl}amino)-6-fluoro-1,3-benzothiazole-4-carboxamide
Authors:Li, J., Xu, Y.
Deposit date:2014-03-26
Release date:2015-04-01
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors
Tetrahedron, 70, 2017
4QPL
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CRYSTAL STRUCTURE OF RNF146(RING-WWE)/UBCH5A/ISO-ADPR COMPLEX
Descriptor:E3 ubiquitin-protein ligase RNF146, Ubiquitin-conjugating enzyme E2 D1, 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), ...
Authors:Wang, Z., DaRosa, P.A., Klevit, R.E., Xu, W.
Deposit date:2014-06-23
Release date:2014-10-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Nature, 517, 2015
4ZW9
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CRYSTAL STRUCTURE OF HUMAN GLUT3 BOUND TO D-GLUCOSE IN THE OUTWARD-OCCLUDED CONFORMATION AT 1.5 ANGSTROM
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Deng, D., Sun, P.C., Yan, C.Y., Yan, N.
Deposit date:2015-05-19
Release date:2015-07-22
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:Molecular basis of ligand recognition and transport by glucose transporters
Nature, 526, 2015
4ZWB
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CRYSTAL STRUCTURE OF MALTOSE-BOUND HUMAN GLUT3 IN THE OUTWARD-OCCLUDED CONFORMATION AT 2.4 ANGSTROM
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, MALTOSE
Authors:Deng, D., Sun, P.C., Yan, C.Y., Yan, N.
Deposit date:2015-05-19
Release date:2015-07-22
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis of ligand recognition and transport by glucose transporters
Nature, 526, 2015
4ZWC
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CRYSTAL STRUCTURE OF MALTOSE-BOUND HUMAN GLUT3 IN THE OUTWARD-OPEN CONFORMATION AT 2.6 ANGSTROM
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Deng, D., Sun, P.C., Yan, C.Y., Yan, N.
Deposit date:2015-05-19
Release date:2015-07-22
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of ligand recognition and transport by glucose transporters
Nature, 526, 2015
5GPR
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CRYSTAL STRUCTURE OF CHITINASE-H FROM OSTRINIA FURNACALIS
Descriptor:Chitinase, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, T., Zhou, Y., Chen, L., Yang, Q.
Deposit date:2016-08-04
Release date:2017-01-11
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase.
J. Biol. Chem., 292, 2017
5GQB
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CRYSTAL STRUCTURE OF CHITINASE-H FROM O. FURNACALIS IN COMPLEX WITH CHITOHEPATOSE
Descriptor:Chitinase, D-GLUCOSAMINE, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, T., Zhou, Y., Chen, L., Yang, Q.
Deposit date:2016-08-06
Release date:2017-01-11
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase.
J. Biol. Chem., 292, 2017
5L4T
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CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 2-DEOXY-HEPTYLMANNOSIDE
Descriptor:Protein FimH, 2-Deoxy-Heptylmannoside
Authors:Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B.
Deposit date:2016-05-26
Release date:2017-06-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
5L4U
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CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 2-FLUORO-HEPTYLMANNOSIDE
Descriptor:Protein FimH, 2-Fluoro-Heptylmannoside
Authors:Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B.
Deposit date:2016-05-26
Release date:2017-06-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
5L4V
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CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 3-DEOXY-HEPTYLMANNOSIDE
Descriptor:Protein FimH, 3-Deoxy-Heptylmannoside
Authors:Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, T.
Deposit date:2016-05-26
Release date:2017-06-21
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
5L4W
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CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 3-FLUORO-HEPTYLMANNOSIDE
Descriptor:Protein FimH, 3-Fluoro-Heptylmannoside
Authors:Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B.
Deposit date:2016-05-26
Release date:2017-06-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
5L4X
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CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 4-DEOXY-HEPTYLMANNOSIDE
Descriptor:Protein FimH, 4-Deoxy-Heptylmannoside
Authors:Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B.
Deposit date:2016-05-26
Release date:2017-06-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
5L4Y
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CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 4-FLUORO-HEPTYLMANNOSIDE
Descriptor:Protein FimH, 4-Fluoro-Heptylmannoside
Authors:Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B.
Deposit date:2016-05-26
Release date:2017-06-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
5MUC
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CRYSTAL STRUCTURE OF THE FIMH LECTIN DOMAIN IN COMPLEX WITH 1,5-ANHYDROMANNITOL
Descriptor:Protein FimH, 1,5-Anhydromannitol
Authors:Jakob, R.P., Rabbani, S., Ernst, B., Maier, T.
Deposit date:2017-01-13
Release date:2018-02-14
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists.
Chemistry, 24, 2018
5WBH
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STRUCTURE OF THE FRB DOMAIN OF MTOR BOUND TO A SUBSTRATE RECRUITMENT PEPTIDE OF S6K1
Descriptor:Serine/threonine-protein kinase mTOR, Ribosomal protein S6 kinase beta-1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBU
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CRYSTAL STRUCTURE OF MTOR(DELTAN)-MLST8-PRAS40(ALPHA-HELIX & BETA-STRAND) COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBY
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CRYSTAL STRUCTURE OF MTOR(DELTAN)-MLST8-PRAS40(BETA-STRAND) COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5XLT
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THE CRYSTAL STRUCTURE OF TUBULIN IN COMPLEX WITH 4'-DEMETHYLEPIPODOPHYLLOTOXIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Yu, Y., Chen, Q.
Deposit date:2017-05-11
Release date:2017-09-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
Biochem. Biophys. Res. Commun., 493, 2017
6AVO
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CRYO-EM STRUCTURE OF HUMAN IMMUNOPROTEASOME WITH A NOVEL NONCOMPETITIVE INHIBITOR THAT SELECTIVELY INHIBITS ACTIVATED LYMPHOCYTES
Descriptor:Proteasome subunit beta type-9, Proteasome subunit beta type-10, Proteasome subunit beta type-8, ...
Authors:Li, H., Santos, R., Bai, L.
Deposit date:2017-09-04
Release date:2017-12-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
Nat Commun, 8, 2017