Author results

5J5L
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CRYSTAL STRUCTURE OF AFMP4P IN COMPLEX WITH ARACHIDONIC ACID
Descriptor:Uncharacterized protein, ARACHIDONIC ACID
Authors:Zhang, H., Hao, Q.
Deposit date:2016-04-03
Release date:2017-04-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Novel Class Of Virulence Factors In Penicillium Marneffei And Aspergillus Fumigatus Enhances Intracellular Survival In Monocytes By Arachidonic Acid Binding
To Be Published
5NBG
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STRUCTURE OF THE CYTOPLASMIC DOMAIN I OF OUTF IN THE D. DADANTII TYPE II SECRETION SYSTEM
Descriptor:General secretion pathway protein F
Authors:Zhang, H., Gu, S.
Deposit date:2017-03-01
Release date:2018-03-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the first cytoplasmic domain of OutF and assembly of the inner-membrane platform proteins of the D. dadantii type II secretion system
To Be Published
5UNF
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XFEL STRUCTURE OF HUMAN ANGIOTENSIN II TYPE 2 RECEPTOR (MONOCLINIC FORM) IN COMPLEX WITH COMPOUND 1 (N-BENZYL-N-(2-ETHYL-4-OXO-3-{[2'-(2H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL])
Descriptor:Chimera protein of Type-2 angiotensin II receptor and Soluble cytochrome b562, N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide
Authors:Zhang, H., Han, G.W., Batyuk, A., Ishchenko, A., White, K.L., Patel, N., Sadybekov, A., Zamlynny, B., Rudd, M.T., Hollenstein, K., Tolstikova, A., White, T.A., Hunter, M.S., Weierstall, U., Liu, W., Babaoglu, K., Moore, E.L., Katz, R.D., Shipman, J.M., Garcia-Calvo, M., Sharma, S., Sheth, P., Soisson, S.M., Stevens, R.C., Katritch, V., Cherezov, V.
Deposit date:2017-01-30
Release date:2017-04-05
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for selectivity and diversity in angiotensin II receptors.
Nature, 544, 2017
5UNG
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XFEL STRUCTURE OF HUMAN ANGIOTENSIN II TYPE 2 RECEPTOR (ORTHORHOMBIC FORM) IN COMPLEX WITH COMPOUND 1 (N-BENZYL-N-(2-ETHYL-4-OXO-3-{[2'-(2H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL] METHYL}-3,4-DIHYDROQUINAZOLIN-6-YL)THIOPHENE-2-CARBOXAMIDE)
Descriptor:Chimera protein of Type-2 angiotensin II receptor and Soluble cytochrome b562, N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Zhang, H., Han, G.W., Batyuk, A., Ishchenko, A., White, K.L., Patel, N., Sadybekov, A., Zamlynny, B., Rudd, M.T., Hollenstein, K., Tolstikova, A., White, T.A., Hunter, M.S., Weierstall, U., Liu, W., Babaoglu, K., Moore, E.L., Katz, R.D., Shipman, J.M., Garcia-Calvo, M., Sharma, S., Sheth, P., Soisson, S.M., Stevens, R.C., Katritch, V., Cherezov, V.
Deposit date:2017-01-30
Release date:2017-04-05
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for selectivity and diversity in angiotensin II receptors.
Nature, 544, 2017
5UNH
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SYNCHROTRON STRUCTURE OF HUMAN ANGIOTENSIN II TYPE 2 RECEPTOR IN COMPLEX WITH COMPOUND 2 (N-[(FURAN-2-YL)METHYL]-N-(4-OXO-2-PROPYL-3-{[2'-(2H-TETRAZOL-5-YL)[1,1'- BIPHENYL]-4-YL]METHYL}-3,4-DIHYDROQUINAZOLIN-6-YL)BENZAMIDE)
Descriptor:Soluble cytochrome b562,Type-2 angiotensin II receptor, N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide
Authors:Zhang, H., Han, G.W., Batyuk, A., Ishchenko, A., White, K.L., Patel, N., Sadybekov, A., Zamlynny, B., Rudd, M.T., Hollenstein, K., Tolstikova, A., White, T.A., Hunter, M.S., Weierstall, U., Liu, W., Babaoglu, K., Moore, E.L., Katz, R.D., Shipman, J.M., Garcia-Calvo, M., Sharma, S., Sheth, P., Soisson, S.M., Stevens, R.C., Katritch, V., Cherezov, V.
Deposit date:2017-01-30
Release date:2017-04-05
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for selectivity and diversity in angiotensin II receptors.
Nature, 544, 2017
5WD6
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BOVINE SALIVARY PROTEIN FORM 30B
Descriptor:Short palate, lung and nasal epithelium carcinoma-associated protein 2B, CALCIUM ION
Authors:Zhang, H., Arcus, V.L.
Deposit date:2017-07-04
Release date:2018-07-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:BSP30b
To Be Published
5XB0
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1.6 A CRYSTAL STRUCTURE OF PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PPIASE FROM PSEUDOMONAS SYRINGAE PV. TOMATO STR. DC3000 (PSPTO DC3000)
Descriptor:Peptidyl-prolyl cis-trans isomerase, L(+)-TARTARIC ACID
Authors:Zhang, H., Gao, Y., Li, M., Chang, W.
Deposit date:2017-03-15
Release date:2017-04-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:1.6 A crystal structure of peptidyl-prolyl cis-trans isomerase PPIase from Pseudomonas syringae pv. tomato str. DC3000 (PSPTO DC3000)
To Be Published
5XOO
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THE STRUCTURE OF HYDRA FAM20 WITH SUGAR
Descriptor:Glycosaminoglycan xylosylkinase, N-ACETYL-D-GLUCOSAMINE, TOLUENE, ...
Authors:Zhang, H., Xiao, J.
Deposit date:2017-05-29
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure and evolution of the Fam20 kinases
Nat Commun, 9, 2018
5YH0
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THE STRUCTURE OF DRFAM20C1
Descriptor:DrFam20C1
Authors:Zhang, H., Xiao, J.
Deposit date:2017-09-27
Release date:2018-04-11
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structure and evolution of the Fam20 kinases
Nat Commun, 9, 2018
5YH2
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THE STRUCTURE OF DRFAM20C1 AND HFAM20A COMPLEX
Descriptor:Pseudokinase FAM20A, Family with sequence similarity 20, member Ca, ...
Authors:Zhang, H., Xiao, J.
Deposit date:2017-09-27
Release date:2018-04-11
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structure and evolution of the Fam20 kinases
Nat Commun, 9, 2018
5Z4P
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-COMPOUND TCA COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhang, H., Luo, C.
Deposit date:2018-01-12
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery and Design of novel Tubulin inhibitors
To Be Published
5ZIO
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CRYSTAL STRUCTURE OF NDM-1 IN COMPLEX WITH L-CAPTOPRIL
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, L-CAPTOPRIL
Authors:Zhang, H., Hao, Q.
Deposit date:2018-03-16
Release date:2019-03-20
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Crystal structure of NDM-1
to be published
5ZJ1
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CRYSTAL STRUCTURE OF NDM-1 IN COMPLEX WITH D-CAPTOPRIL DERIVATIVE CYT-14
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, methyl (2R)-2-(phenylmethoxycarbonylamino)-3-sulfanyl-propanoate, ...
Authors:Zhang, H., Hao, Q.
Deposit date:2018-03-18
Release date:2019-03-20
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal structure of NDM-1
to be published
5ZJ2
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CRYSTAL STRUCTURE OF NDM-1 IN COMPLEX WITH D-CAPTOPRIL
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID
Authors:Zhang, H., Hao, Q.
Deposit date:2018-03-18
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure of NDM-1
to be published
5ZJ7
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CRYSTAL STRUCTURE OF NDM-1 IN COMPLEX WITH D-CAPTOPRIL DERIVATIVE CY22
Descriptor:Metallo-beta-lactamase type 2, (2R)-2-methyl-N-(phenylmethyl)-3-sulfanyl-propanamide, 1,2-ETHANEDIOL, ...
Authors:Zhang, H., Hao, Q.
Deposit date:2018-03-19
Release date:2019-03-20
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal structure of NDM-1
to be published
5ZJ8
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CRYSTAL STRUCTURE OF NDM-1 IN COMPLEX WITH D-CAPTOPRIL DERIVATIVE CY32
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, (2S)-2,3-disulfanylpropan-1-ol, ...
Authors:Zhang, H., Hao, Q.
Deposit date:2018-03-19
Release date:2019-03-20
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal structure of NDM-1
to be published
5ZJC
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CRYSTAL STRUCTURE OF NDM-1 IN COMPLEX WITH D-CAPTOPRIL DERIVATIVE CY41
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Zhang, H., Hao, Q.
Deposit date:2018-03-20
Release date:2019-03-20
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal structure of NDM-1
to be published
6CKO
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CRYSTAL STRUCTURE OF AN AF10 FRAGMENT
Descriptor:Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ...
Authors:Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-28
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6NFX
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MBTD1 MBT REPEATS
Descriptor:MBT domain-containing protein 1,Enhancer of polycomb homolog 1, UNKNOWN ATOM OR ION, SODIUM ION, ...
Authors:Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-12-21
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:MBTD1 MBT repeats
To Be Published
6O1T
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BOVINE SALIVARY PROTEIN FORM 30B WITH OLEIC ACID
Descriptor:Short palate, lung and nasal epithelium carcinoma-associated protein 2B, CALCIUM ION, ...
Authors:Zhang, H., Arcus, V.L.
Deposit date:2019-02-21
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of BSP30B with oleic acid at 2.3 Angstroms resolution
To Be Published
3PCU
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CRYSTAL STRUCTURE OF HUMAN RETINOIC X RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH LX0278 AND SRC1 PEPTIDE
Descriptor:Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate
Authors:Zhang, H., Zhang, Y., Shen, H., Chen, J., Li, C., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-10-22
Release date:2011-11-16
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice.
Plos One, 7, 2012
3UAS
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CYTOCHROME P450 2B4 COVALENTLY BOUND TO THE MECHANISM-BASED INACTIVATOR 9-ETHYNYLPHENANTHRENE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, phenanthren-9-ylacetaldehyde, ...
Authors:Gay, S.C., Zhang, H., Shah, M.B., Stout, C.D., Halpert, J.R., Hollenberg, P.F.
Deposit date:2011-10-21
Release date:2013-01-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.939 Å)
Cite:Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis.
Biochemistry, 52, 2013
5H21
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TRIMETHOXY-RING INHIBITOR IN COMPLEX WITH THE FIRST BROMODOMAIN OF BRD4
Descriptor:Bromodomain-containing protein 4, 3,4,5-trimethoxy-~{N}-(2-thiophen-2-ylethyl)benzamide
Authors:Zhang, H., Luo, C.
Deposit date:2016-10-13
Release date:2017-07-05
Method:X-RAY DIFFRACTION (1.591 Å)
Cite:Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.
Medchemcomm, 8, 2017
5WUU
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COMPLEX STRUCTURE OF THE FIRST BROMODOMAIN OF BRD4 WITH AN INHIBITOR THAT CONTAINING A 2H-CHROMEN-2-ONE RING
Descriptor:Bromodomain-containing protein 4, ~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide
Authors:Zhang, H., Sun, Z.Y.
Deposit date:2016-12-21
Release date:2017-04-12
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.724 Å)
Cite:Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.
Bioorg. Med. Chem. Lett., 27, 2017
5Z5T
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THE FIRST BROMODOMAIN OF BRD4 WITH COMPOUND BDF-2141
Descriptor:Bromodomain-containing protein 4, 2-amino-4-(1H-imidazol-1-yl)quinolin-8-ol
Authors:Zhang, H., Luo, C.
Deposit date:2018-01-20
Release date:2019-01-23
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.
Oncogenesis, 7, 2018