Author results

4XHB
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH PENTANEDIOL AND CHES
Descriptor:Sialidase B, (1R,2S)-cyclopentane-1,2-diol, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Brear, P.
Deposit date:2015-01-05
Release date:2016-01-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XHX
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH OPTACTIN AND 2-[(3-CHLOROBENZYL)AMMONIO]ETHANESULFONATE
Descriptor:Sialidase B, 2-[(3-chlorobenzyl)amino]ethanesulfonic acid, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, ...
Authors:Brear, P.
Deposit date:2015-01-06
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XIK
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CRYSTAL STRUCTURE OF NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH DMSO
Descriptor:Sialidase B, DIMETHYL SULFOXIDE
Authors:Brear, P.
Deposit date:2015-01-07
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XIL
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH OPTACTIN AT PH 7.4 IN PBS WITH MPD AS THE CRYOPROTECTANT
Descriptor:Sialidase B, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid
Authors:Brear, P.
Deposit date:2015-01-07
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XIO
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CRYSTAL STRUCTURE OF APO NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE AT PH 8.0 WITH MPD AS THE CRYOPROTECTANT
Descriptor:Sialidase B
Authors:Brear, P.
Deposit date:2015-01-07
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XJ8
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CRYSTAL STRUCTURE OF APO NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE AT PH 5.0 IN 50MM SODIUM ACETATE WITH DMSO
Descriptor:Sialidase B
Authors:Brear, P.
Deposit date:2015-01-08
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.749 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XJ9
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH OPTACTIN AT PH 5.0 IN 50MM SODIUM ACETATE WITH DMSO AS THE CRYOPROTECTANT
Descriptor:Sialidase B, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE
Authors:Brear, P.
Deposit date:2015-01-08
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XJA
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH 5-ACETAMIDO-2,3-DIFLUORO-3-HYDROXY-6-[1,2,3-TRIHYDROXYPROPYL]OXANE-2-CARBOXYLIC ACID
Descriptor:Sialidase B, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, PHOSPHATE ION, ...
Authors:Brear, P.
Deposit date:2015-01-08
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XJU
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH 4-ACETAMIDO-2-FLUORO-3-HYDROXY-6-[1,2-DIHYDROXYETHYL]-7,8-DIOXABICYCLO[3.2.1]OCTANE-1-CARBOXYLIC ACID
Descriptor:Sialidase B, DIMETHYL SULFOXIDE, PHOSPHATE ION, ...
Authors:Brear, P.
Deposit date:2015-01-09
Release date:2016-01-13
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XJW
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH OPTACTIN AT PH 7.4 IN PBS WITH DMSO AS THE CRYOPROTECTANT
Descriptor:Sialidase B, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, ...
Authors:Brear, P.
Deposit date:2015-01-09
Release date:2016-01-13
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XJZ
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CRYSTAL STRUCTURE OF APO NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE AT PH 7.4 IN PBS WITH DMSO
Descriptor:Sialidase B, PHOSPHATE ION, DIMETHYL SULFOXIDE
Authors:Brear, P.
Deposit date:2015-01-09
Release date:2016-01-13
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XMA
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CRYSTAL STRUCTURE OF THE K499G MUTANT OF NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH OPTACTIN
Descriptor:Sialidase B, DIMETHYL SULFOXIDE, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid
Authors:Brear, P.
Deposit date:2015-01-14
Release date:2016-02-03
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XMI
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CRYSTAL STRUCTURE OF THE K499G MUTANT OF NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Sialidase B, DIMETHYL SULFOXIDE, PHOSPHATE ION
Authors:Brear, P.
Deposit date:2015-01-14
Release date:2016-01-13
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XOG
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CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH OPTACTIN AND DANA
Descriptor:Sialidase B, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, ...
Authors:Brear, P.
Deposit date:2015-01-16
Release date:2016-02-03
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
5T09
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THE STRUCTURE OF THE TYPE III EFFECTOR HOPBA1
Descriptor:Type III secretion system effector HopBA1, POTASSIUM ION, CHLORIDE ION
Authors:Cherkis, K., Machius, M., Nishimura, M.T., Dangl, J.L.
Deposit date:2016-08-15
Release date:2017-02-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.013 Å)
Cite:TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WQ1
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SOLUTION STRUCTURE OF THE FIRST STEM-LOOP OF ESCHERICHIA COLI DSRA RNA
Descriptor:DsrA-SL1
Authors:Wu, P., Wu, J., Shi, Y.
Deposit date:2016-11-22
Release date:2017-07-05
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:The important conformational plasticity of DsrA sRNA for adapting multiple target regulation
Nucleic Acids Res., 45, 2017
5YQ7
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CRYO-EM STRUCTURE OF THE RC-LH CORE COMPLEX FROM ROSEIFLEXUS CASTENHOLZII
Descriptor:Beta subunit of light-harvesting 1, Precursor for L subunits of photosynthetic reaction center, Cytochrome subunit of photosynthetic reaction center, ...
Authors:Shi, Y., Xin, Y.Y., Niu, T.X., Wang, Q.Q., Niu, W.Q., Huang, X.J., Ding, W., Blankenship, R.E., Xu, X.L., Sun, F.
Deposit date:2017-11-05
Release date:2018-05-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the RC-LH core complex from an early branching photosynthetic prokaryote.
Nat Commun, 9, 2018
5ZLU
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RIBOSOME STRUCTURE BOUND TO ABC-F PROTEIN.
Descriptor:RNA (25-mer), 30S ribosomal protein S17, 30S ribosomal protein S18, ...
Authors:Su, W.X., Kumar, V., Ero, R., Andrew, S.W.W., Jian, S., Yong-Gui, G.
Deposit date:2018-03-29
Release date:2018-08-01
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Ribosome protection by antibiotic resistance ATP-binding cassette protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BG3
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STRUCTURE OF (3S,4S)-1-BENZYL-4-(3-(3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PIPERIDIN-3-YL ACETATE BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
6BG5
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STRUCTURE OF 1-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)-1-(1-PROPYLPIPERIDIN-4-YL)-3-(3-(TRIFLUOROMETHYL)PHENYL)UREA BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018