Author results

5F9H
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CRYSTAL STRUCTURE OF RIG-I HELICASE-RD IN COMPLEX WITH 24-MER 5' TRIPHOSPHATE HAIRPIN RNA
Descriptor:Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(P*AP*AP*UP*AP*UP*AP*AP*UP*AP*GP*UP*GP*AP*UP*AP*UP*UP*AP*UP*AP*UP*UP*C)-3'), ZINC ION, ...
Authors:Wang, C., Marcotrigiano, J., Miller, M., Jiang, F.
Deposit date:2015-12-09
Release date:2016-01-13
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Proc.Natl.Acad.Sci.USA, 113, 2016
5H5D
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THE CRYSTAL STRUCTURE OF THE YEAST ARGININE METHYLTRANSFERASE SFM1 COMPLEXED WITH MTA
Descriptor:Protein arginine N-methyltransferase SFM1, 5'-DEOXY-5'-METHYLTHIOADENOSINE
Authors:Xie, W., Wang, C., Zeng, J.
Deposit date:2016-11-05
Release date:2017-01-18
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1.
FEBS Lett., 591, 2017
5H5E
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THE CRYSTAL STRUCTURE OF THE YEAST ARGININE METHYLTRANSFERASE SFM1 COMPLEXED WITH SAH
Descriptor:Protein arginine N-methyltransferase SFM1, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Xie, W., Wang, C., Zeng, J.
Deposit date:2016-11-05
Release date:2017-01-18
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1.
FEBS Lett., 591, 2017
5H5F
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THE CRYSTAL STRUCTURE OF THE YEAST ARGININE METHYLTRANSFERASE SFM1 COMPLEXED WITH SAM
Descriptor:Protein arginine N-methyltransferase SFM1, S-ADENOSYLMETHIONINE
Authors:Xie, W., Wang, C., Zeng, J.
Deposit date:2016-11-05
Release date:2017-01-18
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1.
FEBS Lett., 591, 2017
5HJI
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CRYSTAL STRUCTURE OF PYROCOCCUS ABYSSI TRM5A COMPLEXED WITH ADENOSINE
Descriptor:tRNA (guanine(37)-N1)-methyltransferase Trm5a, ADENOSINE
Authors:Xie, W., Wang, C., Jia, Q.
Deposit date:2016-01-13
Release date:2016-10-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Sci Rep, 6, 2016
5HJJ
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CRYSTAL STRUCTURE OF PYROCOCCUS ABYSSI TRM5A
Descriptor:tRNA (guanine(37)-N1)-methyltransferase Trm5a
Authors:Xie, W., Wang, C., Jia, Q.
Deposit date:2016-01-13
Release date:2016-10-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Sci Rep, 6, 2016
5HJK
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CRYSTAL STRUCTURE OF PYROCOCCUS ABYSSI TRM5A COMPLEXED WITH SAH
Descriptor:tRNA (guanine(37)-N1)-methyltransferase Trm5a, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Xie, W., Wang, C., Jia, Q.
Deposit date:2016-01-13
Release date:2016-10-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Sci Rep, 6, 2016
5HJM
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CRYSTAL STRUCTURE OF PYROCOCCUS ABYSSI TRM5A COMPLEXED WITH MTA
Descriptor:tRNA (guanine(37)-N1)-methyltransferase Trm5a, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ACETATE ION, ...
Authors:Xie, W., Wang, C., Jia, Q.
Deposit date:2016-01-13
Release date:2016-10-12
Method:X-RAY DIFFRACTION (1.762 Å)
Cite:Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Sci Rep, 6, 2016
5WT1
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PYROCOCCUS ABYSSI METHYLTRANSFERASE PATRM5A BOUND BY SAH AND COGNATE TRNA
Descriptor:tRNA (guanine(37)-N1)-methyltransferase Trm5a, RNA (76-MER), S-ADENOSYL-L-HOMOCYSTEINE
Authors:Xie, W., Wang, C., Jia, Q.
Deposit date:2016-12-09
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Structural insight into the methyltransfer mechanism of the bifunctional Trm5
Sci Adv, 3, 2017
5WT3
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PYROCOCCUS ABYSSI METHYLTRANSFERASE PATRM5A BOUND BY MTA AND COGNATE TRNA
Descriptor:tRNA (guanine(37)-N1)-methyltransferase Trm5a, RNA (73-MER), 5'-DEOXY-5'-METHYLTHIOADENOSINE
Authors:Xie, W., Wang, C., Jia, Q.
Deposit date:2016-12-09
Release date:2017-12-13
Method:X-RAY DIFFRACTION (3.204 Å)
Cite:Structural insight into the methyltransfer mechanism of the bifunctional Trm5
Sci Adv, 3, 2017
5XOE
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CRYSTAL STRUCTURE OF THE APO STAPHYLOCOCCUS AUREUS PHOSPHOFRUCTOKINASE
Descriptor:ATP-dependent 6-phosphofructokinase
Authors:Wang, C., Tian, T., Zang, J.
Deposit date:2017-05-27
Release date:2018-06-20
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion.
Biochemistry, 57, 2018
6A9X
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CRYSTAL STRUCTURE OF ANKG/GABARAP COMPLEX
Descriptor:Gamma-aminobutyric acid receptor-associated protein, Ankyrin-3
Authors:Wang, C., Li, J., Chen, K., Zhang, M.
Deposit date:2018-07-16
Release date:2018-12-26
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
Mol. Psychiatry, 2018
4NC3
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CRYSTAL STRUCTURE OF THE 5-HT2B RECEPTOR SOLVED USING SERIAL FEMTOSECOND CRYSTALLOGRAPHY IN LIPIDIC CUBIC PHASE.
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, PALMITIC ACID, Ergotamine, ...
Authors:Liu, W., Wacker, D., Gati, C., Han, G.W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N.A., Li, D., Messerschmidt, M., Boutet, S., Williams, G.J., Koglin, J.E., Seibert, M.M., Wang, C., Shah, S.T.A., Basu, S., Fromme, R., Kupitz, C., Rendek, K.N., Grotjohann, I., Fromme, P., Kirian, R.A., Beyerlein, K.R., White, T.A., Chapman, H.N., Caffrey, M., Spence, J.C.H., Stevens, R.C., Cherezov, V., GPCR Network (GPCR)
Deposit date:2013-10-23
Release date:2013-12-18
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Serial femtosecond crystallography of G protein-coupled receptors.
Science, 342, 2013
5YQX
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CRYSTAL STRUCTURE ANALYSIS OF THE BRD4
Descriptor:Bromodomain-containing protein 4, (2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one, 1,2-ETHANEDIOL, ...
Authors:Xue, X., Zhang, Y., Wang, C., Song, M.
Deposit date:2017-11-08
Release date:2018-11-28
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer.
Eur.J.Med.Chem., 152, 2018
2JQC
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A L-AMINO ACID MUTANT OF A D-AMINO ACID CONTAINING CONOPEPTIDE
Descriptor:L-mr12
Authors:Huang, F., Du, W., Han, Y., Wang, C., Chi, C.
Deposit date:2007-05-31
Release date:2008-04-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus
Febs J., 275, 2008
4ZA1
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CRYSTAL STRUCTURE OF NOSA INVOLVED IN NOSIHEPTIDE BIOSYNTHESIS
Descriptor:NosA, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Liu, S., Guo, H., Zhang, T., Han, L., Yao, P., Zhang, Y., Rong, N., Yu, Y., Lan, W., Wang, C., Ding, J., Wang, R., Liu, W., Cao, C.
Deposit date:2015-04-13
Release date:2015-08-19
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis
Sci Rep, 5, 2015
5Y8Y
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CRYSTAL STRUCTURE ANALYSIS OF THE BRD4
Descriptor:Bromodomain-containing protein 4, NITRATE ION, 1,2-ETHANEDIOL, ...
Authors:Xu, Y., Zhang, Y., Song, M., Wang, C.
Deposit date:2017-08-21
Release date:2018-06-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018
1YM0
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CRYSTAL STRUCTURE OF EARTHWORM FIBRINOLYTIC ENZYME COMPONENT B: A NOVEL, GLYCOSYLATED TWO-CHAINED TRYPSIN
Descriptor:fibrinotic enzyme component B, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Wang, F., Wang, C., Li, M., Zhang, J.P., Gui, L.L., An, X.M., Chang, W.R.
Deposit date:2005-01-20
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structure of earthworm fibrinolytic enzyme component B: a novel, glycosylated two-chained trypsin.
J.Mol.Biol., 348, 2005
2YYF
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PURIFICATION AND STRUCTURAL CHARACTERIZATION OF A D-AMINO ACID CONTAINING CONOPEPTIDE, MARMOPHINE, FROM CONUS MARMOREUS
Descriptor:M-conotoxin mr12
Authors:Huang, F., Du, W., Han, Y., Wang, C.
Deposit date:2007-04-29
Release date:2008-04-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus.
Febs J., 275, 2008
4N9B
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1-methyl-N-(pyridin-3-yl)-1H-pyrazole-5-carboxamide
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhai, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.859 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9C
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, 5-nitro-1H-benzimidazole, PHOSPHATE ION
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9D
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, PHOSPHATE ION, ...
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9E
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, 1-[(1-benzoylpiperidin-4-yl)methyl]-N-(pyridin-3-yl)-1H-benzimidazole-5-carboxamide, PHOSPHATE ION, ...
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
6KKH
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CRYSTAL STRUCTURE OF THE OXALATE BOUND MALYL-COA LYASE FROM ROSEIFLEXUS CASTENHOLZII
Descriptor:HpcH/HpaI aldolase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, OXALATE ION, ...
Authors:Tang, W.R., Wang, Z.G., Zhang, C.Y., Wang, C.
Deposit date:2019-07-25
Release date:2019-09-04
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii.
Biochem.Biophys.Res.Commun., 518, 2019
5Y8C
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CRYSTAL STRUCTURE ANALYSIS OF THE BRD4
Descriptor:Bromodomain-containing protein 4, NITRATE ION, 5-chloranyl-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzoxazol-5-yl)benzenesulfonamide, ...
Authors:Xu, Y., Zhang, Y., Song, M., Wang, C.
Deposit date:2017-08-21
Release date:2018-06-13
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018