Author results

3QWL
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CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 7
Descriptor:TBC1 domain family member 7, UNKNOWN ATOM OR ION
Authors:Guan, X., Tempel, W., Tong, Y., Wernimont, A.K., Landry, R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-02-28
Release date:2011-06-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human TBC1 domain family member 7
to be published
3R90
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CRYSTAL STRUCTURE OF MALIGNANT T CELL-AMPLIFIED SEQUENCE 1 PROTEIN
Descriptor:Malignant T cell-amplified sequence 1, SULFATE ION, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Tong, Y., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-03-24
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Malignant T cell-amplified sequence 1 protein
to be published
3R93
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CRYSTAL STRUCTURE OF THE CHROMO DOMAIN OF M-PHASE PHOSPHOPROTEIN 8 BOUND TO H3K9ME3 PEPTIDE
Descriptor:M-phase phosphoprotein 8, H3K9Me3 peptide, UNKNOWN ATOM OR ION
Authors:Li, J., Li, Z., Ruan, J., Xu, C., Tong, Y., Pan, P.W., Tempel, W., Crombet, L., Min, J., Zang, J., Structural Genomics Consortium (SGC)
Deposit date:2011-03-24
Release date:2011-04-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.057 Å)
Cite:Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.
Plos One, 6, 2011
3RPX
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CRYSTAL STRUCTURE OF COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN, C1QBP
Descriptor:Complement component 1 Q subcomponent-binding protein, UNKNOWN ATOM OR ION
Authors:Tempel, W., Tong, Y., Crombet, L., Shen, Y., Guan, X., Nedyalkova, L., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-04-27
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of complement component 1, q subcomponent binding protein, C1QBP
to be published
3S4Y
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CRYSTAL STRUCTURE OF HUMAN THIAMIN PYROPHOSPHOKINASE 1
Descriptor:Thiamin pyrophosphokinase 1, THIAMINE DIPHOSPHATE, SULFATE ION, ...
Authors:Shen, L., Tempel, W., Tong, Y., Li, Y., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-05-20
Release date:2011-06-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human thiamin pyrophosphokinase 1
to be published
3TUG
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CRYSTAL STRUCTURE OF THE HECT DOMAIN OF ITCH E3 UBIQUITIN LIGASE
Descriptor:E3 ubiquitin-protein ligase Itchy homolog, CHLORIDE ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Dobrovetsky, E., Xue, S., Butler, C., Wernimont, A., Walker, J.R., Tempel, W., Dhe-Paganon, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2011-09-16
Release date:2011-10-12
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
To be Published
3V70
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CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILY MEMBER 1
Descriptor:GTPase IMAP family member 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Nedyalkova, L., Shen, Y., Tong, Y., Tempel, W., Mackenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Andrews, D.W., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-12-20
Release date:2012-01-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Crystal Structure of Human GTPase IMAP family member 1
to be published
4E71
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CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXIN B2
Descriptor:Plexin-B2, SODIUM ION
Authors:Guan, X., Wang, H., Tempel, W., Tong, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2012-03-16
Release date:2012-03-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of the RHO GTPASE binding domain of Plexin B2
to be published
4E74
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CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXIN A4A
Descriptor:Plexin-A4, UNKNOWN ATOM OR ION
Authors:Guan, X., Wang, H., Tempel, W., Dong, A., Tong, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2012-03-16
Release date:2012-03-28
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A
to be published
4EZA
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CRYSTAL STRUCTURE OF THE ATYPICAL PHOSPHOINOSITIDE (API) BINDING DOMAIN OF IQGAP2
Descriptor:Ras GTPase-activating-like protein IQGAP2
Authors:Van Aalten, D.M.F., Dixon, M.J., Gray, A., Schenning, M., Agacan, M., Leslie, N.R., Downes, C.P., Batty, I.H., Nedyalkova, L., Tempel, W., Tong, Y., Zhong, N., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2012-05-02
Release date:2012-05-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold.
J.Biol.Chem., 287, 2012
4FO9
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CRYSTAL STRUCTURE OF THE E3 SUMO LIGASE PIAS2
Descriptor:E3 SUMO-protein ligase PIAS2, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Hu, J., Dobrovetsky, E., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2012-06-20
Release date:2012-07-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal structure of the E3 SUMO Ligase PIAS2
to be published
4GLM
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN OF DNMBP PROTEIN [HOMO SAPIENS]
Descriptor:Dynamin-binding protein, UNKNOWN ATOM OR ION
Authors:Dong, A., Guan, X., Huang, H., Tempel, W., Gu, J., Sidhu, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2012-08-14
Release date:2012-11-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens]
to be published
4IIM
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CRYSTAL STRUCTURE OF THE SECOND SH3 DOMAIN OF ITSN1 BOUND WITH A SYNTHETIC PEPTIDE
Descriptor:Intersectin-1, peptide ligand, UNKNOWN ATOM OR ION
Authors:Dong, A., Guan, X., Huang, H., Wernimont, A., Gu, J., Sidhu, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2012-12-20
Release date:2013-01-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide
To be Published
4IIO
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CRYSTAL STRUCTURE OF THE SECOND SH3 DOMAIN OF ITSN2 BOUND WITH A SYNTHETIC PEPTIDE
Descriptor:Intersectin-2, Synthetic Peptide, CHLORIDE ION, ...
Authors:Dong, A., Guan, X., Huang, H., Gu, J., Tempel, W., Sidhu, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2012-12-20
Release date:2013-12-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide
TO BE PUBLISHED
4IQ6
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GSK-3BETA WITH INHIBITOR 6-CHLORO-N-CYCLOHEXYL-4-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIDIN-2-AMINE
Descriptor:Glycogen synthase kinase-3 beta, 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine
Authors:Tong, Y., Stewart, K.D., Florjancic, A.S., Harlan, J.E., Merta, P.J., Przytulinska, M., Soni, N., Swinger, K.S., Zhu, H., Johnson, E.F., Shoemaker, A.R., Penning, T.D.
Deposit date:2013-01-10
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.
ACS Med Chem Lett, 4, 2013
4JUY
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CRYSTAL STRUCTURE OF THE PUB DOMAIN OF E3 UBIQUITIN LIGASE RNF31
Descriptor:E3 ubiquitin-protein ligase RNF31, UNKNOWN ATOM OR ION
Authors:Dong, A., Hu, J., Li, Y., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2013-03-25
Release date:2013-04-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31
To be Published
4L1M
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STRUCTURE OF THE FIRST RCC1-LIKE DOMAIN OF HERC2
Descriptor:E3 ubiquitin-protein ligase HERC2, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Tempel, W., Khan, M.B., Dong, A., Hu, J., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2013-06-03
Release date:2013-07-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the first RCC1-like domain of HERC2
TO BE PUBLISHED
4MVT
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CRYSTAL STRUCTURE OF SUMO E3 LIGASE PIAS3
Descriptor:E3 SUMO-protein ligase PIAS3, ZINC ION, CHLORIDE ION, ...
Authors:Dong, A., Hu, J., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2013-09-24
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of SUMO E3 Ligase PIAS3
to be published
4NRM
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 IN COMPLEX WITH CITRATE AND ACETATE
Descriptor:RNA demethylase ALKBH5, CITRATE ANION, ACETATE ION
Authors:Feng, C., Chen, Z., Liu, Y.
Deposit date:2013-11-27
Release date:2014-03-19
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289, 2014
4NRO
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 IN COMPLEX WITH ALPHA-KETOGLUTARATE
Descriptor:RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID
Authors:Feng, C., Chen, Z., Liu, Y.
Deposit date:2013-11-27
Release date:2014-03-19
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289, 2014
4NRP
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 IN COMPLEX WITH N-OXALYLGLYCINE
Descriptor:RNA demethylase ALKBH5, MANGANESE (II) ION, N-OXALYLGLYCINE
Authors:Feng, C., Chen, Z., Liu, Y.
Deposit date:2013-11-27
Release date:2014-03-19
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289, 2014
4NRQ
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 IN COMPLEX WITH PYRIDINE-2,4-DICARBOXYLATE
Descriptor:RNA demethylase ALKBH5, PYRIDINE-2,4-DICARBOXYLIC ACID, MANGANESE (II) ION
Authors:Feng, C., Chen, Z., Liu, Y.
Deposit date:2013-11-27
Release date:2014-03-19
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289, 2014
4O2W
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CRYSTAL STRUCTURE OF THE THIRD RCC1-LIKE DOMAIN OF HERC1
Descriptor:E3 ubiquitin-protein ligase HERC1, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Dong, A., Hu, J., Li, Y., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2013-12-17
Release date:2014-01-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the third RCC1-like domain of HERC1
To be Published
4O7X
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 IN COMPLEX WITH MN2+
Descriptor:RNA demethylase ALKBH5, MANGANESE (II) ION
Authors:Feng, C., Chen, Z., Liu, Y.
Deposit date:2013-12-26
Release date:2014-03-19
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289, 2014
4PYZ
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CRYSTAL STRUCTURE OF THE FIRST TWO UBL DOMAINS OF DEUBIQUITYLASE USP7
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, UNKNOWN ATOM OR ION
Authors:Walker, J.R., Dong, A., Ong, M.S., Dhe-Paganon, S., Kania, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-03-28
Release date:2014-04-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Crystal structure of the first two Ubl domains of Deubiquitylase USP7
to be published