Author results

4V24
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SPHINGOSINE KINASE 1 IN COMPLEX WITH PF-543
Descriptor:SPHINGOSINE KINASE 1, {(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL, ACETATE ION
Authors:Elkins, J.M., Wang, J., Sorrell, F., Tallant, C., Wang, D., Shrestha, L., Bountra, C., von Delft, F., Knapp, S., Edwards, A.
Deposit date:2014-10-05
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Sphingosine Kinase 1 with Pf-543.
Acs Med.Chem.Lett., 5, 2014
5AIL
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HUMAN PARP9 2ND MACRODOMAIN
Descriptor:POLY [ADP-RIBOSE] POLYMERASE 9, 1,2-ETHANEDIOL, POLYETHYLENE GLYCOL (N=34), ...
Authors:Sieg, C., Shrestha, L., Talon, R., Sorrell, F., Williams, E., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Elkins, J.M.
Deposit date:2015-02-15
Release date:2015-02-25
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of Parp9 2Nd Macrodomain
To be Published
5FII
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STRUCTURE OF A HUMAN ASPARTATE KINASE, CHORISMATE MUTASE AND TYRA DOMAIN.
Descriptor:PHENYLALANINE-4-HYDROXYLASE, PHENYLALANINE
Authors:Patel, D., Kopec, J., Shrestha, L., Fitzpatrick, F., Pinkas, D., Chaikuad, A., Dixon-Clarke, S., McCorvie, T.J., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2015-09-25
Release date:2016-03-30
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Ligand-Dependent Dimerization of Phenylalanine Hydroxylase Regulatory Domain.
Sci.Rep., 6, 2016
5FWJ
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CRYSTAL STRUCTURE OF HUMAN JARID1C IN COMPLEX WITH KDM5-C49
Descriptor:HISTONE DEMETHYLASE JARID1C, MAGNESIUM ION, ZINC ION, ...
Authors:Srikannathasan, V., Szykowska, A., Strain-Damerell, C., Kopec, J., Nowak, R., Gileadi, C., Johansson, C., Kupinska, K., Burgess-Brown, N.A., Shrestha, L., Dong, W., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Huber, K., Oppermann, U.
Deposit date:2016-02-17
Release date:2016-04-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5LUG
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN-2B PROTEIN IN COMPLEX WITH ART(M3L)QTA(2MR)KS PEPTIDE
Descriptor:Spindlin-like protein 2, isoform CRA_a, ALA-ARG-THR-M3L-GLN-THR-ALA-2MR-LYS-SER, ...
Authors:Srikannathasan, V., Gileadi, C., Talon, R., Shrestha, L., Kopec, J., Szykowska, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Oppermann, U., Huber, K.
Deposit date:2016-09-08
Release date:2017-09-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human Spindlin-2B protein in complex with ART(M3L)QTA(2MR)KS peptide
To be published
5NFJ
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CRYSTAL STRUCTURE OF THE METHYLTRANSFERASE SUBUNIT OF HUMAN MITOCHONDRIAL RIBONUCLEASE P (MRPP1) BOUND TO S-ADENOSYL-METHIONINE (SAM)
Descriptor:Mitochondrial ribonuclease P protein 1, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:Oerum, S., Kopec, J., Fitzpatrick, F., Newman, J.A., Chalk, R., Shrestha, L., Fairhead, M., Talon, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, C., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2017-03-14
Release date:2018-05-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM)
To Be Published