1CTN
| CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION | Descriptor: | CHITINASE A | Authors: | Perrakis, A, Tews, I, Dauter, Z, Wilson, K.S, Vorgias, C.E. | Deposit date: | 1994-10-10 | Release date: | 1995-02-07 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of a bacterial chitinase at 2.3 A resolution. Structure, 2, 1994
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6QCG
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8ARF
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7P0K
| Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand | Descriptor: | 2-[[2-ethyl-6-[4-[2-[(3~{R})-3-fluoranylpyrrolidin-1-yl]-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-2,3-dihydro-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Salgado-Polo, F, Shao, T, Xiao, Z, Van, R, Chen, J, Rong, J, Haider, A, Shao, Y, Josephson, L, Perrakis, A, Liang, S.H. | Deposit date: | 2021-06-29 | Release date: | 2022-07-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands J Med Chem, 64, 2021
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6NVQ
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1DCS
| DEACETOXYCEPHALOSPORIN C SYNTHASE FROM S. CLAVULIGERUS | Descriptor: | DEACETOXYCEPHALOSPORIN C SYNTHASE, SULFATE ION | Authors: | Valegard, K, Terwisscha Van Scheltinga, A.C, Lloyd, M.D, Hara, T, Ramaswamy, S, Perrakis, A, Thompson, A, Lee, H.J, Baldwin, J.E, Schofield, C.J, Hajdu, J, Andersson, I. | Deposit date: | 1998-06-05 | Release date: | 1999-06-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure of a cephalosporin synthase. Nature, 394, 1998
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5C9N
| Crystal structure of GEMC1 coiled-coil domain | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Geminin coiled-coil domain-containing protein 1 | Authors: | Caillat, C, Perrakis, A. | Deposit date: | 2015-06-28 | Release date: | 2015-11-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins. Acta Crystallogr.,Sect.D, 71, 2015
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6FPV
| A llama-derived JBP1-targeting nanobody | Descriptor: | GLYCEROL, Nanobody | Authors: | van Beusekom, B, Adamopoulos, A, Heidebrecht, T, Joosten, R.P, Perrakis, A. | Deposit date: | 2018-02-12 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1. Acta Crystallogr F Struct Biol Commun, 74, 2018
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3KJY
| Crystal structure of reduced HOMO SAPIENS CLIC3 | Descriptor: | Chloride intracellular channel protein 3, SULFATE ION | Authors: | Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. | Deposit date: | 2009-11-04 | Release date: | 2009-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of human CLIC3 at 2 A resolution Proteins, 78, 2010
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7Z5G
| human apo MATCAP | Descriptor: | Uncharacterized protein KIAA0895-like | Authors: | Bak, J, Adamoupolos, A, Heidebrecht, T, Perrakis, A. | Deposit date: | 2022-03-09 | Release date: | 2022-05-11 | Last modified: | 2022-06-01 | Method: | X-RAY DIFFRACTION (2.113 Å) | Cite: | Posttranslational modification of microtubules by the MATCAP detyrosinase. Science, 376, 2022
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5DLV
| Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) | Descriptor: | 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | Authors: | Keune, W.J, Heidebrecht, T, von Castelmur, E, Joosten, R.P, Perrakis, A. | Deposit date: | 2015-09-07 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7, 2016
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5DLT
| Crystal structure of Autotaxin (ENPP2) with 7-alpha-hydroxycholesterol | Descriptor: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | Authors: | Hausmann, J, Joosten, R.P, Perrakis, A. | Deposit date: | 2015-09-07 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7, 2016
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5DLW
| Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA) | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, ... | Authors: | Keune, W.J, Heidebrecht, T, Joosten, R.P, Perrakis, A. | Deposit date: | 2015-09-07 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7, 2016
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7Z5H
| human Zn MATCAP | Descriptor: | Uncharacterized protein KIAA0895-like, ZINC ION | Authors: | Bak, J, Adamopoulos, A, Heidebrecht, T, Perrakis, A. | Deposit date: | 2022-03-09 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Posttranslational modification of microtubules by the MATCAP detyrosinase. Science, 376, 2022
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5IJQ
| Crystal structure of autotaxin (ENPP2) re-refined | Descriptor: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | Authors: | Hausmann, J, Joosten, R.P, Perrakis, A. | Deposit date: | 2016-03-02 | Release date: | 2016-06-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. J.Struct.Biol., 195, 2016
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5IJS
| Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | Authors: | Hausmann, J, Joosten, R.P, Perrakis, A. | Deposit date: | 2016-03-02 | Release date: | 2016-06-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. J.Struct.Biol., 195, 2016
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7Z6S
| MATCAP bound to a human 14 protofilament microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Bak, J, Perrakis, A. | Deposit date: | 2022-03-14 | Release date: | 2022-05-11 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Posttranslational modification of microtubules by the MATCAP detyrosinase. Science, 376, 2022
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7ZOT
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2W8G
| Aplysia californica AChBP bound to in silico compound 35 | Descriptor: | (3-ENDO,8-ANTI)-8-BENZYL-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8-AZONIABICYCLO[3.2.1]OCTANE, SOLUBLE ACETYLCHOLINE RECEPTOR | Authors: | Ulens, C, Akdemir, A, Jongejan, A, van Elk, R, Edink, E, Bertrand, S, Perrakis, A, Leurs, R, Smit, A.B, Sixma, T.K, Bertrand, D, de Esch, I.J. | Deposit date: | 2009-01-16 | Release date: | 2009-04-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis. J.Med.Chem., 52, 2009
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7Z0N
| Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators | Descriptor: | CALCIUM ION, GLYCEROL, IODIDE ION, ... | Authors: | Salgado-Polo, F, Clark, J.M, Macdonald, S.J.F, Barrett, T.N, Perrakis, A, Jamieson, A. | Deposit date: | 2022-02-23 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. J.Med.Chem., 65, 2022
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6GVJ
| Human Mps1 kinase domain with ordered activation loop | Descriptor: | CHLORIDE ION, Dual specificity protein kinase TTK, GLYCEROL | Authors: | Roorda, J.C, Hiruma, Y, Joosten, R.P, Perrakis, A. | Deposit date: | 2018-06-21 | Release date: | 2019-01-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop. Proteins, 87, 2019
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3G73
| Structure of the FOXM1 DNA binding | Descriptor: | DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ... | Authors: | Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H. | Deposit date: | 2009-02-09 | Release date: | 2009-03-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence Nucleic Acids Res., 2010
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2CKL
| Ring1b-Bmi1 E3 catalytic domain structure | Descriptor: | IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ... | Authors: | Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K. | Deposit date: | 2006-04-20 | Release date: | 2006-05-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B. Embo J., 25, 2006
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7Z3K
| Autotaxin in complex with orthosteric site-binder CpdA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | Authors: | Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A. | Deposit date: | 2022-03-02 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Autotaxin facilitates selective LPA receptor signaling. Cell Chem Biol, 30, 2023
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7Z3L
| Autotaxin in complex with hybrid compound ziritaxestat (GLPG1690) | Descriptor: | 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A. | Deposit date: | 2022-03-02 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Autotaxin facilitates selective LPA receptor signaling. Cell Chem Biol, 30, 2023
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