Author results

6BVM
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2017-12-13
公開日2018-10-24
実験手法X-RAY DIFFRACTION (1.796 Å)
主引用文献Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 2018
6CUO
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2018-03-26
公開日2019-02-06
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9, 2018
6CUP
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2018-03-26
公開日2019-02-06
実験手法X-RAY DIFFRACTION (1.833 Å)
主引用文献Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9, 2018
6CUR
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2018-03-26
公開日2019-02-06
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9, 2018
6D55
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D56
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D59
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5E
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5G
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5H
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5J
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5L
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5M
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (2.081 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5V
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018