Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
8EIR
DownloadVisualize
BU of 8eir by Molmil
SARS-CoV-2 polyprotein substrate regulates the stepwise Mpro cleavage reaction
Descriptor: 3C-like proteinase nsp5, nsp7-nsp10 of Replicase polyprotein 1a
Authors:Narwal, M, Edwards, T, Armache, J.P, Murakami, K.S.
Deposit date:2022-09-15
Release date:2023-04-26
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:SARS-CoV-2 polyprotein substrate regulates the stepwise M pro cleavage reaction.
J.Biol.Chem., 299, 2023
8EKE
DownloadVisualize
BU of 8eke by Molmil
Cryo-EM structure of SARS CoV-2 Mpro WT protease
Descriptor: 3C-like proteinase nsp5
Authors:Narwal, M, Edwards, T, Armache, J.P, Murakami, K.S.
Deposit date:2022-09-20
Release date:2023-04-26
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:SARS-CoV-2 polyprotein substrate regulates the stepwise M pro cleavage reaction.
J.Biol.Chem., 299, 2023
4ZTB
DownloadVisualize
BU of 4ztb by Molmil
Crystal structure of nsP2 protease from Chikungunya virus in P212121 space group at 2.59 A (4molecules/ASU).
Descriptor: GLYCEROL, Protease nsP2
Authors:Narwal, M, Pratap, S, Singh, H, Kumar, P, Tomar, S.
Deposit date:2015-05-14
Release date:2016-06-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site.
Int.J.Biol.Macromol., 116, 2018
5MZF
DownloadVisualize
BU of 5mzf by Molmil
Crystal structure of dog MTH1 protein
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Narwal, M, Jemth, A.-S, Helleday, T, Stenmark, P.
Deposit date:2017-01-31
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
5MZG
DownloadVisualize
BU of 5mzg by Molmil
Crystal structure of mouse MTH1 in complex with TH588
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, SULFATE ION, ...
Authors:Narwal, M, Jemth, A.-S, Helleday, T, Stenmark, P.
Deposit date:2017-01-31
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
5MZE
DownloadVisualize
BU of 5mze by Molmil
Crystal structure of mouse MTH1 with 8-oxo-dGTP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, COPPER (II) ION, ...
Authors:Narwal, M, Jemth, A.-S, Helleday, T, Stenmark, P.
Deposit date:2017-01-31
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
3U9Y
DownloadVisualize
BU of 3u9y by Molmil
Crystal structure of human tankyrase 2 catalytic domain in complex with olaparib
Descriptor: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Lehtio, L.
Deposit date:2011-10-20
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of selective inhibition of human tankyrases.
J.Med.Chem., 55, 2012
3U9H
DownloadVisualize
BU of 3u9h by Molmil
Complex structure of human tankyrase 2 with nicotinamide
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, NICOTINAMIDE, ...
Authors:Narwal, M, Lehtio, L.
Deposit date:2011-10-19
Release date:2011-11-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis of selective inhibition of human tankyrases.
J.Med.Chem., 55, 2012
3UA9
DownloadVisualize
BU of 3ua9 by Molmil
Crystal structure of human tankyrase 2 in complex with a selective inhibitor
Descriptor: 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Narwal, M, Lehtio, L.
Deposit date:2011-10-21
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of selective inhibition of human tankyrases.
J.Med.Chem., 55, 2012
4HKK
DownloadVisualize
BU of 4hkk by Molmil
Complex structure of human tankyrase 2 with apigenin
Descriptor: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLK
DownloadVisualize
BU of 4hlk by Molmil
Crystal structure of Tankyrase 2 in complex with 4'-methylflavone
Descriptor: 2-(4-methylphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLM
DownloadVisualize
BU of 4hlm by Molmil
Crystal structure of Tankyrase 2 in complex with 3',4'-Dihydroxyflavone
Descriptor: 2-(3,4-dihydroxyphenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HMH
DownloadVisualize
BU of 4hmh by Molmil
Crystal structure of tankyrase 2 in complex with 7,3-dihydroxyflavone
Descriptor: 7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-18
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLF
DownloadVisualize
BU of 4hlf by Molmil
Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone
Descriptor: 2-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLG
DownloadVisualize
BU of 4hlg by Molmil
Crystal structure of Tankyrase 2 in complex with 3'-hydroxyflavone
Descriptor: 2-(3-hydroxyphenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HKI
DownloadVisualize
BU of 4hki by Molmil
Tankyrase 2 in complex with flavone
Descriptor: 2-PHENYL-4H-CHROMEN-4-ONE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLH
DownloadVisualize
BU of 4hlh by Molmil
Crystal structure of Tankyrase 2 in complex with 4'-fluoroflavone
Descriptor: 2-(4-fluorophenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HL5
DownloadVisualize
BU of 4hl5 by Molmil
Complex structure of human tankyrase 2 with 7-hydroxy -4'-methoxyflavone
Descriptor: 7-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-16
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HKN
DownloadVisualize
BU of 4hkn by Molmil
Complex structure of human tankyrase 2 with luteolin
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SULFATE ION, Tankyrase-2, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4L09
DownloadVisualize
BU of 4l09 by Molmil
Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-4H-chromen-2-yl)benzoic acid
Descriptor: 4-(4-oxo-4H-chromen-2-yl)benzoic acid, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-05-31
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L31
DownloadVisualize
BU of 4l31 by Molmil
Tankyrase 2 in complex with methyl 4-(4-oxochromen-2-yl)benzoate
Descriptor: GLYCEROL, SULFATE ION, Tankyrase-2, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-05
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4KZU
DownloadVisualize
BU of 4kzu by Molmil
Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone
Descriptor: 2-(4-bromophenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-05-30
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L32
DownloadVisualize
BU of 4l32 by Molmil
Tankyrase 2 in complex with 2-[4-(4-methylpiperazine-1-carbonyl)phenyl]chromen-4-one
Descriptor: 2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-05
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L34
DownloadVisualize
BU of 4l34 by Molmil
Tankyrase 2 in complex with 4'-tetrazole flavone
Descriptor: 2-[4-(1H-tetrazol-5-yl)phenyl]-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-05
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4KZQ
DownloadVisualize
BU of 4kzq by Molmil
Crystal structure of human tankyrase 2 in complex with 4' -hydroxy flavone
Descriptor: 2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE, SULFATE ION, Tankyrase-2, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-05-30
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013

 

1234>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon