Author results

5WNF
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X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
分子名称:Rho-associated protein kinase 1, 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1H-1,2,3-triazole-4-carboxamide, GLYCEROL
著者Li, X.
登録日2017-07-31
公開日2018-08-01
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Novel mechanism of Rho kinase selectivity: beyond the ATP pocket
To Be Published
5WNG
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X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
分子名称:Rho-associated protein kinase 1, (2R)-N-(3-cyanophenyl)-2-(3-{[(6S)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide
著者Li, X.
登録日2017-07-31
公開日2018-08-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Novel mechanism of Rho kinase selectivity: beyond the ATP pocket
To Be Published
5WNH
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X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
分子名称:Rho-associated protein kinase 1, (2R)-N-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide
著者Li, X.
登録日2017-07-31
公開日2018-08-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Novel mechanism of Rho kinase selectivity: beyond the ATP pocket
To Be Published
5YGI
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN INHIBITOR THZ93
分子名称:Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ...
著者Li, X.
登録日2017-09-23
公開日2018-09-26
最終更新日2019-04-10
実験手法X-RAY DIFFRACTION (2.177 Å)
主引用文献The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175, 2018
3EFH
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CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1
分子名称:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
著者Li, X., Peng, X., Li, Y.
登録日2008-09-08
公開日2008-09-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of human phosphoribosyl pyrophosphate synthetase 1
To be Published
3PDV
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STRUCTURE OF THE PDLIM2 PDZ DOMAIN IN COMPLEX WITH THE C-TERMINAL 6-PEPTIDE EXTENSION OF NS1
分子名称:PDZ and LIM domain protein 2, C-teminal peptide from Nonstructural protein 1, SODIUM ION
著者Li, X.
登録日2010-10-25
公開日2011-09-07
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1
Plos One, 6, 2011
3EQT
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CRYSTAL STRUCTURE OF HUMAN LGP2 C-TERMINAL DOMAIN IN COMPLEX WITH DSRNA
分子名称:ATP-dependent RNA helicase DHX58, 5'-R(*GP*CP*GP*CP*GP*CP*GP*C)-3', ZINC ION
著者Li, P., Li, X.
登録日2008-10-01
公開日2009-03-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA
J.Biol.Chem., 284, 2009
4RED
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CRYSTAL STRUCTURE OF HUMAN AMPK ALPHA1 KD-AID WITH K43A MUTATION
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-1
著者Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
登録日2014-09-22
公開日2014-12-10
最終更新日2015-03-11
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4RER
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED HUMAN ALPHA1 BETA2 GAMMA1 HOLO-AMPK COMPLEX BOUND TO AMP AND CYCLODEXTRIN
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
登録日2014-09-23
公開日2014-12-10
最終更新日2015-03-11
実験手法X-RAY DIFFRACTION (4.047 Å)
主引用文献Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4REW
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CRYSTAL STRUCTURE OF THE NON-PHOSPHORYLATED HUMAN ALPHA1 BETA2 GAMMA1 HOLO-AMPK COMPLEX
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
登録日2014-09-24
公開日2014-12-10
最終更新日2015-03-11
実験手法X-RAY DIFFRACTION (4.58 Å)
主引用文献Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
1ZGK
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1.35 ANGSTROM STRUCTURE OF THE KELCH DOMAIN OF KEAP1
分子名称:Kelch-like ECH-associated protein 1
著者Li, X., Bottoms, C.A., Hannink, M., Beamer, L.J.
登録日2005-04-21
公開日2005-10-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1.
Acta Crystallogr.,Sect.D, 61, 2005
3NDM
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CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A POTENT ISOQUINOLONE DERIVATIVE
分子名称:Rho-Associated Protein Kinase (ROCK1), (3S,4R)-N-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide
著者Li, X.
登録日2010-06-07
公開日2010-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines.
Bioorg.Med.Chem.Lett., 20, 2010
2F3A
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SOLUTION STRUCTURE OF THE LL-37-DERIVED AUREIN 1.2 ANALOG (LLAA) IN MEMBRANE-MIMETIC MICELLES
分子名称:aurein 1.2 analog
著者Wang, G., Li, X., Peterkofsky, A.
登録日2005-11-19
公開日2006-10-17
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR studies of aurein 1.2 analogs
BIOCHIM.BIOPHYS.ACTA, 1758, 2006
2FBS
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SOLUTION STRUCTURE OF THE LL-37 CORE PEPTIDE BOUND TO DETERGENT MICELLES
分子名称:Antibacterial protein FALL-39, core peptide
著者Wang, G., Li, X.
登録日2005-12-10
公開日2006-05-23
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region
J.Am.Chem.Soc., 128, 2006
2FBU
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SOLUTION STRUCTURE OF THE N-TERMINAL FRAGMENT OF HUMAN LL-37
分子名称:Antibacterial protein FALL-39, core peptide
著者Wang, G., Li, X.
登録日2005-12-10
公開日2006-05-23
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region
J.Am.Chem.Soc., 128, 2006
2FCG
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SOLUTION STRUCTURE OF THE C-TERMINAL FRAGMENT OF HUMAN LL-37
分子名称:Antibacterial protein FALL-39, core peptide
著者Wang, G., Li, X.
登録日2005-12-12
公開日2006-05-23
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region.
J.Am.Chem.Soc., 128, 2006
2M9H
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DNA-BINDING DOMAIN OF T. BRUCEI TELOMERIC PROTEIN TBTRF
分子名称:TTAGGG binding factor
著者Li, X., Ye, F., Zhang, M., Zhao, Y.
登録日2013-06-09
公開日2014-07-16
最終更新日2014-11-26
実験手法SOLUTION NMR
主引用文献Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity.
Nucleic Acids Res., 42, 2014
4WWJ
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UNDA, AN OXYGEN-ACTIVATING, NON-HEME IRON DEPENDENT DESATURASE/DECARBOXYLASE
分子名称:TENA/THI-4 family protein, FE (III) ION, GLYCEROL, ...
著者Li, X., Cate, J.D.H.
登録日2014-11-11
公開日2014-12-24
最終更新日2015-01-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase.
Proc.Natl.Acad.Sci.USA, 111, 2014
4WWZ
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UNDA COMPLEXED WITH 2,3-DODECENOIC ACID
分子名称:TENA/THI-4 family protein, FE (III) ION, (2E)-dodec-2-enoic acid, ...
著者Li, X., Cate, J.D.H.
登録日2014-11-13
公開日2014-12-24
最終更新日2015-01-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase.
Proc.Natl.Acad.Sci.USA, 111, 2014
4WX0
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UNDA COMPLEXED WITH BETA-HYDROXYDODECANOIC ACID
分子名称:TENA/THI-4 family protein, FE (III) ION, (3R)-3-HYDROXYDODECANOIC ACID, ...
著者Li, X., Cate, J.D.H.
登録日2014-11-13
公開日2014-12-24
最終更新日2015-01-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase.
Proc.Natl.Acad.Sci.USA, 111, 2014
5EE0
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CRYSTAL STRUCTURE OF OSYCHF1 AT PH 6.5
分子名称:Obg-like ATPase 1
著者Li, X., Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2016-03-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
5EE1
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CRYSTAL STRUCTURE OF OSYCHF1 AT PH 7.85
分子名称:Obg-like ATPase 1
著者Li, X., Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2016-03-23
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
5EE3
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COMPLEX STRUCTURE OF OSYCHF1 WITH AMP-PNP
分子名称:Obg-like ATPase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Li, X., Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2016-03-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
5EE9
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COMPLEX STRUCTURE OF OSYCHF1 WITH GMP-PNP
分子名称:Obg-like ATPase 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ...
著者Li, X., Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2016-03-23
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
2FLU
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CRYSTAL STRUCTURE OF THE KELCH-NEH2 COMPLEX
分子名称:Kelch-like ECH-associated protein 1, Nrf2
著者Li, X., Lo, J., Beamer, L., Hannink, M.
登録日2006-01-06
公開日2006-08-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Embo J., 25, 2006