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2VX2
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CRYSTAL STRUCTURE OF HUMAN ENOYL COENZYME A HYDRATASE DOMAIN- CONTAINING PROTEIN 3 (ECHDC3)
Descriptor:ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3
Authors:Yue, W.W., Guo, K., Kochan, G., Pilka, E., Murray, J.W., Salah, E., Cocking, R., Sun, Z., Roos, A.K., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-06-30
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Enoyl Coenzyme a Hydratase Domain-Containing Protein 3 (Echdc3)
To be Published
2WM8
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CRYSTAL STRUCTURE OF HUMAN MAGNESIUM-DEPENDENT PHOSPHATASE 1 OF THE HALOACID DEHALOGENASE SUPERFAMILY (MGC5987)
Descriptor:MAGNESIUM-DEPENDENT PHOSPHATASE 1, 1,2-ETHANEDIOL
Authors:Yue, W.W., Shafqat, N., Pike, A.C.W., Chaikuad, A., Bray, J.E., Pilka, E.W., Burgess-Brown, N., Hapka, E., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-06-30
Release date:2009-07-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Human Magnesium-Dependent Phosphatase 1 of the Haloacid Dehalogenase Superfamily (Mgc5987)
To be Published
2XXZ
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CRYSTAL STRUCTURE OF THE HUMAN JMJD3 JUMONJI DOMAIN
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 6B, NICKEL (II) ION, SODIUM ION, ...
Authors:Che, K.H., Yue, W.W., Krojer, T., Muniz, J.R.C., Ng, S.S., Tumber, A., Daniel, M., Burgess-Brown, N., Savitsky, P., Ugochukwu, E., Filippakopoulos, P., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-11-12
Release date:2010-11-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Human Jmjd3 Jumonji Domain
To be Published
4AKV
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CRYSTAL STRUCTURE OF HUMAN SORTING NEXIN 33 (SNX33)
Descriptor:SORTING NEXIN-33, SULFATE ION
Authors:Oberholzer, A., Froese, D.S., Krojer, T., Shrestha, L., Filippakopoulos, P., Muniz, J.R.C., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2012-02-29
Release date:2012-08-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Structure of Human Sorting Nexin 33
To be Published
4AOT
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CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 (LOK) BOUND TO GW830263A
Descriptor:Serine/threonine-protein kinase 10, CHLORIDE ION, 1-(4-{methyl[2-({4-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]amino}phenyl)-3-{3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea
Authors:Elkins, J.M., Salah, E., Szklarz, M., Canning, P., von Delft, F., Yue, W., Liu, Y., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2012-03-29
Release date:2012-04-11
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal Structure of Human Serine Threonine Kinase-10 (Lok) Bound to Gw830263A
To be Published
4APC
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CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1 (NEK1)
Descriptor:SERINE/THREONINE-PROTEIN KINASE NEK1, CHLORIDE ION
Authors:Elkins, J.M., Hanchuk, T.D.M., Lovato, D.V., Basei, F.L., Meirelles, G.V., Kobarg, J., Szklarz, M., Vollmar, M., Mahajan, P., Rellos, P., Zhang, Y., Krojer, T., Pike, A.C.W., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2012-04-02
Release date:2012-04-25
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Human Nima-Related Kinase 1
To be Published
4AZ9
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CRYSTAL STRUCTURE OF PHOX HOMOLOGY DOMAIN OF HUMAN SORTING NEXIN 24
Descriptor:SORTING NEXIN-24, 1,2-ETHANEDIOL
Authors:Oberholzer, A.E., Kiyani, W., Krojer, T., Shrestha, L., von Delft, F., Froese, D.S., Chaikuad, A., Raynor, J., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2012-06-24
Release date:2012-10-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Phox Homology Domain of Human Sorting Nexin 24
To be Published
4B9D
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CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1 (NEK1) WITH INHIBITOR.
Descriptor:SERINE/THREONINE-PROTEIN KINASE NEK1, [4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE, CHLORIDE ION, ...
Authors:Elkins, J.M., Hanchuk, T.D.M., Lovato, D.V., Basei, F.L., Meirelles, G.V., Kobarg, J., Szklarz, M., Vollmar, M., Mahajan, P., Rellos, P., Zhang, Y., Krojer, T., Pike, A.C.W., Canning, P., von Delft, F., Raynor, J., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2012-09-04
Release date:2012-09-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Nima-Related Kinase 1 (Nek1) with Inhibitor.
To be Published
4CCZ
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CRYSTAL STRUCTURE OF HUMAN 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE, THE HOMOCYSTEINE AND FOLATE BINDING DOMAINS
Descriptor:METHIONINE SYNTHASE, (6S)-5,6,7,8-TETRAHYDROFOLATE
Authors:Vollmar, M., Kiyani, W., Krojer, T., Goubin, S., Burgess-Brown, N., von Delft, F., Oppermann, U., Edwards, A., Arrowsmith, C., Bountra, C., Yue, W.W.
Deposit date:2013-10-29
Release date:2013-11-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Human 5-Methyltetrahydrofolate-Homocysteine Methyltransferase, the Homocysteine and Folate Binding Domains
To be Published
4UYB
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CRYSTAL STRUCTURE OF SEC14-LIKE PROTEIN 3
Descriptor:SEC14-LIKE PROTEIN 3, 1,2-ETHANEDIOL, UNKNOWN LIGAND
Authors:Kopec, J., Goubin, S., Krojer, T., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-08-29
Release date:2014-09-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Sec14-Like Protein 3
To be Published
6HRH
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STRUCTURE OF HUMAN ERYTHROID-SPECIFIC 5'-AMINOLEVULINATE SYNTHASE, ALAS2
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bailey, H.J., Shrestha, L., Rembeza, E., Newman, J., Kupinska, K., Diaz-saez, L., Kennedy, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-11-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2
To Be Published
6Q3W
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STRUCTURE OF HUMAN GALACTOKINASE 1 BOUND WITH ETHYL 1-(2-PYRAZINYL)-4-PIPERIDINECARBOXYLATE
Descriptor:Galactokinase, BETA-D-GALACTOSE, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ...
Authors:Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
Deposit date:2018-12-04
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:Structure of human galactokinase 1 bound with Ethyl 1-(2-pyrazinyl)-4-piperidinecarboxylate
To Be Published
6Q8Z
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STRUCTURE OF HUMAN GALACTOKINASE 1 BOUND WITH N-(CYCLOBUTYLMETHYL)-1,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXAMIDE
Descriptor:Galactokinase, BETA-D-GALACTOSE, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ...
Authors:Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
Deposit date:2018-12-16
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide
To Be Published
6Q90
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STRUCTURE OF HUMAN GALACTOKINASE 1 BOUND WITH 1-(4-METHOXYPHENYL)-3-(4-PYRIDINYL)UREA
Descriptor:Galactokinase, BETA-D-GALACTOSE, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ...
Authors:Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
Deposit date:2018-12-16
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human galactokinase 1 bound with 1-(4-Methoxyphenyl)-3-(4-pyridinyl)urea
To Be Published
6Q91
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STRUCTURE OF HUMAN GALACTOKINASE 1 BOUND WITH 5-CHLORO-N-ISOBUTYL-2-METHOXYBENZAMIDE
Descriptor:Galactokinase, BETA-D-GALACTOSE, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ...
Authors:Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
Deposit date:2018-12-17
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human galactokinase 1 bound with 5-Chloro-N-isobutyl-2-methoxybenzamide
To Be Published
6QJE
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STRUCTURE OF HUMAN GALACTOKINASE 1 BOUND WITH 4-{[2-(METHYLSULFONYL)-1H-IMIDAZOL-1-YL]METHYL}-1,3-THIAZOLE
Descriptor:Galactokinase, BETA-D-GALACTOSE, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ...
Authors:Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
Deposit date:2019-01-24
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole
To Be Published
5K5F
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NMR STRUCTURE OF THE HLTF HIRAN DOMAIN
Descriptor:Helicase-like transcription factor
Authors:Bezsonova, I., Neculai, D., Korzhnev, D., Weigelt, J., Bountra, C., Edwards, A., Arrowsmith, C., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2016-05-23
Release date:2016-06-08
Method:SOLUTION NMR
Cite:NMR structure of the HLTF HIRAN domain
To Be Published
1TF1
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CRYSTAL STRUCTURE OF THE E. COLI GLYOXYLATE REGULATORY PROTEIN LIGAND BINDING DOMAIN
Descriptor:Negative regulator of allantoin and glyoxylate utilization operons
Authors:Walker, J.R., Skarina, T., Kudrytska, M., Joachimiak, A., Arrowsmith, C., Edwards, A., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2004-05-26
Release date:2004-08-03
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and biochemical study of effector molecule recognition by the E.coli glyoxylate and allantoin utilization regulatory protein AllR.
J.Mol.Biol., 358, 2006
1GTD
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NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG ID TT50) STRUCTURE OF MTH169, THE PURS SUBUNIT OF FGAM SYNTHETASE
Descriptor:MTH169
Authors:Batra, R., Christendat, D., Saxild, H.H., Arrowsmith, C., Tong, L.
Deposit date:2002-01-14
Release date:2002-12-12
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Crystal Structure of Mth169, a Crucial Component of Phosphoribosylformylglycinamidine Synthetase
Proteins: Struct.,Funct., Genet., 49, 2002
1H2H
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CRYSTAL STRUCTURE OF TM1643
Descriptor:HYPOTHETICAL PROTEIN TM1643, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Yang, Z., Savchenko, A., Edwards, A., Arrowsmith, C., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2002-08-08
Release date:2002-08-15
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.
J. Biol. Chem., 278, 2003
1NEE
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STRUCTURE OF ARCHAEAL TRANSLATION FACTOR AIF2BETA FROM METHANOBACTERIUM THERMOAUTROPHICUM
Descriptor:Probable translation initiation factor 2 beta subunit, ZINC ION
Authors:Gutierrez, P., Trempe, J.F., Siddiqui, N., Arrowsmith, C., Gehring, K.
Deposit date:2002-12-11
Release date:2004-03-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the archaeal translation initiation factor aIF2beta from Methanobacterium thermoautotrophicum: Implications for translation initiation.
Protein Sci., 13, 2004
1NR3
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SOLUTION STRUCTURE OF THE PROTEIN MTH0916: THE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TT212
Descriptor:DNA-binding protein tfx
Authors:Shen, Y., Liu, G., Bhaskaran, R., Yee, A., Arrowsmith, C., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-01-23
Release date:2003-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:SOLUTION STRUCTURE OF THE PROTEIN MTH0916: THE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TT212
To be Published
1OYZ
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X-RAY STRUCTURE OF YIBA_ECOLI NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ET31.
Descriptor:Hypothetical protein yibA
Authors:Kuzin, A., Semesi, A., Skarina, T., Savchenko, A., Arrowsmith, C., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-04-07
Release date:2003-08-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-RAY STRUCTURE OF YIBA_ECOLI NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ET31.
To be Published
1PAV
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SOLUTION NMR STRUCTURE OF HYPOTHETICAL PROTEIN TA1414 OF THERMOPLASMA ACIDOPHILUM
Descriptor:Hypothetical protein Ta1170/Ta1414
Authors:Monleon, D., Yee, A., Liu, C.S., Arrowsmith, C., Celda, B.
Deposit date:2003-05-14
Release date:2003-05-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of hypothetical protein TA1414 from Thermoplasma acidophilum.
J.Biomol.Nmr, 28, 2004
1TXJ
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CRYSTAL STRUCTURE OF TRANSLATIONALLY CONTROLLED TUMOUR-ASSOCIATED PROTEIN (TCTP) FROM PLASMODIUM KNOWLESI
Descriptor:translationally controlled tumour-associated protein (TCTP) from Plasmodium knowlesi, PKN_PFE0545c
Authors:Walker, J.R., Vedadi, M., Sharma, S., Houston, S., Lew, J., Amani, M., Wasney, G., Skarina, T., Bray, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2004-07-05
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007