Author results

1Y8D
  • Download 1y8d
  • View 1y8d
Molmil generated image of 1y8d
DIMERIC PARALLEL-STRANDED TETRAPLEX WITH 3+1 5' G-TETRAD INTERFACE, SINGLE-RESIDUE CHAIN REVERSAL LOOPS AND GAG TRIAD IN THE CONTEXT OF A(GGGG) PENTAD
Descriptor:5'-D(*GP*GP*GP*GP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*GP*T)-3'
Authors:Phan, A.T., Kuryavyi, V.V., Ma, J.-B., Faure, A., Andreola, M.-L., Patel, D.J.
Deposit date:2004-12-11
Release date:2005-02-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase
Proc.Natl.Acad.Sci.USA, 102, 2005
1Y9H
  • Download 1y9h
  • View 1y9h
Molmil generated image of 1y9h
METHYLATION OF CYTOSINE AT C5 IN A CPG SEQUENCE CONTEXT CAUSES A CONFORMATIONAL SWITCH OF A BENZO[A]PYRENE DIOL EPOXIDE-N2-GUANINE ADDUCT IN DNA FROM A MINOR GROOVE ALIGNMENT TO INTERCALATION WITH BASE DISPLACEMENT
Descriptor:5'-D(*CP*CP*AP*TP*(5CM)P*(BPG)P*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3', 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE
Authors:Zhang, N., Lin, C., Huang, X., Kolbanovskiy, A., Hingerty, B.E., Amin, S., Broyde, S., Geacintov, N.E., Patel, D.J.
Deposit date:2004-12-15
Release date:2005-03-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.
J.Mol.Biol., 346, 2005
1YKQ
  • Download 1ykq
  • View 1ykq
Molmil generated image of 1ykq
CRYSTAL STRUCTURE OF DIELS-ALDER RIBOZYME
Descriptor:Diels-Alder ribozyme, CADMIUM ION, MAGNESIUM ION
Authors:Serganov, A., Keiper, S., Malinina, L., Tereshko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan, A.T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A., Patel, D.J.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
1YKV
  • Download 1ykv
  • View 1ykv
Molmil generated image of 1ykv
CRYSTAL STRUCTURE OF THE DIELS-ALDER RIBOZYME COMPLEXED WITH THE PRODUCT OF THE REACTION BETWEEN N-PENTYLMALEIMIDE AND COVALENTLY ATTACHED 9-HYDROXYMETHYLANTHRACENE
Descriptor:Diels-Alder ribozyme, (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, MAGNESIUM ION
Authors:Serganov, A., Keiper, S., Malinina, L., Tereshko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan, A.T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A., Patel, D.J.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
1YLS
  • Download 1yls
  • View 1yls
Molmil generated image of 1yls
CRYSTAL STRUCTURE OF SELENIUM-MODIFIED DIELS-ALDER RIBOZYME COMPLEXED WITH THE PRODUCT OF THE REACTION BETWEEN N-PENTYLMALEIMIDE AND COVALENTLY ATTACHED 9-HYDROXYMETHYLANTHRACENE
Descriptor:RNA Diels-Alder ribozyme, (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, MAGNESIUM ION
Authors:Serganov, A., Keiper, S., Malinina, L., Tereshko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan, A.T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A., Patel, D.J.
Deposit date:2005-01-19
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
1YTU
  • Download 1ytu
  • View 1ytu
Molmil generated image of 1ytu
STRUCTURAL BASIS FOR 5'-END-SPECIFIC RECOGNITION OF THE GUIDE RNA STRAND BY THE A. FULGIDUS PIWI PROTEIN
Descriptor:5'-R(P*AP*GP*AP*CP*AP*G)-3', 5'-R(P*UP*GP*UP*C)-3', hypothetical protein AF1318, ...
Authors:Ma, J.B., Yuan, Y.R., Meister, G., Pei, Y., Tuschl, T., Patel, D.J.
Deposit date:2005-02-11
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.
Nature, 434, 2005
1YTY
  • Download 1yty
  • View 1yty
Molmil generated image of 1yty
STRUCTURAL BASIS FOR RECOGNITION OF UUUOH 3'-TERMINII OF NASCENT RNA POL III TRANSCRIPTS BY LA AUTOANTIGEN
Descriptor:5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein
Authors:Teplova, M., Yuan, Y.R., Ilin, S., Malinina, L., Phan, A.T., Teplov, A., Patel, D.J.
Deposit date:2005-02-11
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen.
Mol.Cell, 21, 2006
1YVU
  • Download 1yvu
  • View 1yvu
Molmil generated image of 1yvu
CRYSTAL STRUCTURE OF A. AEOLICUS ARGONAUTE
Descriptor:hypothetical protein aq_1447, CALCIUM ION
Authors:Yuan, Y.R., Pei, Y., Ma, J.B., Kuryavyi, V., Zhadina, M., Meister, G., Chen, H.Y., Dauter, Z., Tuschl, T., Patel, D.J.
Deposit date:2005-02-16
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage
Mol.Cell, 19, 2005
1ZBH
  • Download 1zbh
  • View 1zbh
Molmil generated image of 1zbh
3'-END SPECIFIC RECOGNITION OF HISTONE MRNA STEM-LOOP BY 3'-EXONUCLEASE
Descriptor:5'-R(*CP*CP*GP*GP*CP*UP*CP*UP*UP*UP*UP*CP*AP*GP*AP*GP*CP*CP*GP*G)-3', 3'-5' exonuclease ERI1, MAGNESIUM ION, ...
Authors:Cheng, Y., Patel, D.J.
Deposit date:2005-04-08
Release date:2006-09-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA
To be Published
1ZBU
  • Download 1zbu
  • View 1zbu
Molmil generated image of 1zbu
CRYSTAL STRUCTURE OF FULL-LENGTH 3'-EXONUCLEASE
Descriptor:3'-5' exonuclease ERI1, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE
Authors:Cheng, Y., Patel, D.J.
Deposit date:2005-04-08
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA
To be Published
1ZH5
  • Download 1zh5
  • View 1zh5
Molmil generated image of 1zh5
STRUCTURAL BASIS FOR RECOGNITION OF UUUOH 3'-TERMINII OF NASCENT RNA POL III TRANSCRIPTS BY LA AUTOANTIGEN
Descriptor:5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein, SULFATE ION
Authors:Teplova, M., Yuan, Y.R., Ilin, S., Malinina, L., Phan, A.T., Teplov, A., Patel, D.J.
Deposit date:2005-04-22
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen.
Mol.Cell, 21, 2006
201D
  • Download 201d
  • View 201d
Molmil generated image of 201d
SOLUTION STRUCTURE OF THE OXYTRICHA TELOMERIC REPEAT D[G4(T4G4)3] G-TETRAPLEX
Descriptor:INTRAMOLECULAR G-TETRAPLEX DNA
Authors:Wang, Y., Patel, D.J.
Deposit date:1995-03-16
Release date:1995-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Oxytricha telomeric repeat d[G4(T4G4)3] G-tetraplex.
J.Mol.Biol., 251, 1995
202D
  • Download 202d
  • View 202d
Molmil generated image of 202d
SOLUTION STRUCTURE OF THE MENOGARIL-DNA COMPLEX
Descriptor:DNA (5'-D(*GP*AP*CP*AP*TP*GP*TP*C)-3'), MENOGARIL
Authors:Chen, H., Patel, D.J.
Deposit date:1995-03-29
Release date:1995-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Menogaril-DNA Complex
J.Am.Chem.Soc., 117, 1995
207D
  • Download 207d
  • View 207d
Molmil generated image of 207d
SOLUTION STRUCTURE OF MITHRAMYCIN DIMERS BOUND TO PARTIALLY OVERLAPPING SITES ON DNA
Descriptor:DNA (5'-D(*TP*AP*GP*CP*TP*AP*GP*CP*TP*A)-3'), 2,6-DIDEOXY-BETA-D-GLUCOSE, 2,6-DIDEOXY-BETA-D-GALACTOSE, ...
Authors:Sastry, M., Fiala, R., Patel, D.J.
Deposit date:1995-04-20
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of mithramycin dimers bound to partially overlapping sites on DNA.
J.Mol.Biol., 251, 1995
2A5P
  • Download 2a5p
  • View 2a5p
Molmil generated image of 2a5p
MONOMERIC PARALLEL-STRANDED DNA TETRAPLEX WITH SNAP-BACK 3+1 3' G-TETRAD, SINGLE-RESIDUE CHAIN REVERSAL LOOPS, GAG TRIAD IN THE CONTEXT OF GAAG DIAGONAL LOOP, NMR, 8 STRUCT.
Descriptor:5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*IP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3'
Authors:Phan, A.T., Kuryavyi, V.V., Gaw, H.Y., Patel, D.J.
Deposit date:2005-06-30
Release date:2005-07-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.
Nat.Chem.Biol., 1, 2005
2A5R
  • Download 2a5r
  • View 2a5r
Molmil generated image of 2a5r
COMPLEX OF TETRA-(4-N-METHYLPYRIDYL) PORPHIN WITH MONOMERIC PARALLEL-STRANDED DNA TETRAPLEX, SNAP-BACK 3+1 3' G-TETRAD, SINGLE-RESIDUE CHAIN REVERSAL LOOPS, GAG TRIAD IN THE CONTEXT OF GAAG DIAGONAL LOOP, C-MYC PROMOTER, NMR, 6 STRUCT.
Descriptor:5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*IP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3', (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin
Authors:Phan, A.T., Kuryavyi, V.V., Gaw, H.Y., Patel, D.J.
Deposit date:2005-06-30
Release date:2005-07-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.
Nat.Chem.Biol., 1, 2005
2ANN
  • Download 2ann
  • View 2ann
Molmil generated image of 2ann
CRYSTAL STRUCTURE (I) OF NOVA-1 KH1/KH2 DOMAIN TANDEM WITH 25 NT RNA HAIRPIN
Descriptor:5'-R(*CP*GP*CP*GP*CP*GP*GP*AP*UP*CP*AP*GP*UP*CP*AP*CP*CP*CP*AP*AP*GP*CP*GP*CP*G)-3', neuro-oncological ventral antigen 1, POTASSIUM ION, ...
Authors:Malinina, L., Teplova, M., Musunuru, K., Teplov, A., Darnell, J.C., Burley, S.K., Darnell, R.B., Patel, D.J.
Deposit date:2005-08-11
Release date:2006-10-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
Structure, 19, 2011
2ANR
  • Download 2anr
  • View 2anr
Molmil generated image of 2anr
CRYSTAL STRUCTURE (II) OF NOVA-1 KH1/KH2 DOMAIN TANDEM WITH 25NT RNA HAIRPIN
Descriptor:5'-R(*CP*(5BU)P*CP*GP*CP*GP*GP*AP*UP*CP*AP*GP*UP*CP*AP*CP*CP*CP*AP*AP*GP*CP*GP*AP*G)-3', neuro-oncological ventral antigen 1, POTASSIUM ION, ...
Authors:Malinina, L., Teplova, M., Musunuru, K., Teplov, A., Darnell, J.C., Burley, S.K., Darnell, R.B., Patel, D.J.
Deposit date:2005-08-11
Release date:2006-10-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
Structure, 19, 2011
2AQY
  • Download 2aqy
  • View 2aqy
Molmil generated image of 2aqy
(3+1) ASSEMBLY OF THREE HUMAN TELOMERIC DNA REPEATS INTO AN ASYMMETRICAL DIMERIC G-QUADRUPLEX
Descriptor:5'-D(*GP*(OIP)P*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*T)-3', 5'-D(*TP*AP*GP*GP*GP*(DU))-3'
Authors:Zhang, N., Phan, A.T., Patel, D.J.
Deposit date:2005-08-18
Release date:2006-03-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:(3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex
J.Am.Chem.Soc., 127, 2005
2ARG
  • Download 2arg
  • View 2arg
Molmil generated image of 2arg
FORMATION OF AN AMINO ACID BINDING POCKET THROUGH ADAPTIVE ZIPPERING-UP OF A LARGE DNA HAIRPIN LOOP, NMR, 9 STRUCTURES
Descriptor:DNA APTAMER [5'-D (*TP*GP*AP*CP*CP*AP*GP*GP*GP*CP*AP*AP*AP*CP*GP*GP*TP*AP* GP*GP*TP*GP*AP*GP*TP*GP*GP*TP*CP*A)-3'], DEOXY-METHYL-ARGININE
Authors:Lin, C.H., Wang, W., Jones, R.A., Patel, D.J.
Deposit date:1998-08-19
Release date:1999-03-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Formation of an amino-acid-binding pocket through adaptive zippering-up of a large DNA hairpin loop.
Chem.Biol., 5, 1998
2ASD
  • Download 2asd
  • View 2asd
Molmil generated image of 2asd
OXOG-MODIFIED INSERTION TERNARY COMPLEX
Descriptor:5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', 5'-D(*CP*T*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', DNA polymerase IV, ...
Authors:Rechkoblit, O., Malinina, L., Cheng, Y., Kuryavyi, V., Broyde, S., Geacintov, N.E., Patel, D.J.
Deposit date:2005-08-23
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2ASJ
  • Download 2asj
  • View 2asj
Molmil generated image of 2asj
OXOG-MODIFIED PREINSERTION BINARY COMPLEX
Descriptor:5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', 5'-D(*CP*TP*AP*AP*CP*(8OG)*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', DNA polymerase IV, ...
Authors:Rechkoblit, O., Malinina, L., Cheng, Y., Kuryavyi, V., Broyde, S., Geacintov, N.E., Patel, D.J.
Deposit date:2005-08-23
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2ASL
  • Download 2asl
  • View 2asl
Molmil generated image of 2asl
OXOG-MODIFIED POSTINSERTION BINARY COMPLEX
Descriptor:5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(DOC))-3', 5'-D(*CP*T*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', DNA polymerase IV, ...
Authors:Rechkoblit, O., Malinina, L., Cheng, Y., Kuryavyi, V., Broyde, S., Geacintov, N.E., Patel, D.J.
Deposit date:2005-08-23
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2ATL
  • Download 2atl
  • View 2atl
Molmil generated image of 2atl
UNMODIFIED INSERTION TERNARY COMPLEX
Descriptor:5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', 5'-D(*CP*T*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', Dpo4 polymerase IV, ...
Authors:Rechkoblit, O., Malinina, L., Cheng, Y., Kuryavyi, V., Broyde, S., Geacintov, N.E., Patel, D.J.
Deposit date:2005-08-25
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2AU0
  • Download 2au0
  • View 2au0
Molmil generated image of 2au0
UNMODIFIED PREINSERTION BINARY COMPLEX
Descriptor:5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', 5'-D(*CP*TP*AP*AP*CP*G*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', Dpo4 polymerase IV, ...
Authors:Rechkoblit, O., Malinina, L., Cheng, Y., Kuryavyi, V., Broyde, S., Geacintov, N.E., Patel, D.J.
Deposit date:2005-08-26
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006