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6A3W
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COMPLEX STRUCTURE OF 4-1BB AND UTOMILUMAB
分子名称:utomilumab VH, utomilumab VL, Tumor necrosis factor receptor superfamily member 9, ...
著者Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
登録日2018-06-17
公開日2018-10-10
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
6GSB
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SPHINGOBACTERIUM SP. T2 MANGANESE SUPEROXIDE DISMUTASE CATALYSES THE OXIDATIVE DEMETHYLATION OF POLYMERIC LIGNIN VIA GENERATION OF HYDROXYL RADICAL
分子名称:Superoxide dismutase, MANGANESE (II) ION
著者Rashid, G.M., Zhang, X., Wilkinson, R.C., Fulop, V., Cottyn, B., Baumberger, S., Bugg, D.H.
登録日2018-06-13
公開日2018-10-03
最終更新日2018-10-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Sphingobacterium sp. T2 Manganese Superoxide Dismutase Catalyzes the Oxidative Demethylation of Polymeric Lignin via Generation of Hydroxyl Radical.
ACS Chem. Biol., 13, 2018
6GSC
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SPHINGOBACTERIUM SP. T2 MANGANESE SUPEROXIDE DISMUTASE CATALYSES THE OXIDATIVE DEMETHYLATION OF POLYMERIC LIGNIN VIA GENERATION OF HYDROXYL RADICAL
分子名称:Superoxide dismutase, MANGANESE (II) ION
著者Rashid, G.M.M., Zhang, X., Wilkinson, R.C., Fulop, V., Cottyn, B., Baumberger, S., Bugg, T.D.H.
登録日2018-06-13
公開日2018-10-03
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Sphingobacterium sp. T2 Manganese Superoxide Dismutase Catalyzes the Oxidative Demethylation of Polymeric Lignin via Generation of Hydroxyl Radical.
ACS Chem. Biol., 13, 2018
6GRB
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH POTASSIUM
分子名称:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
著者Lilley, D.M.J., Liu, Y., Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRC
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH SODIUM
分子名称:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
著者Lilley, D.M.J., Liu, Y., Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.452 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRD
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH CESIUM
分子名称:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
著者Lilley, D.M.J., Liu, Y., Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6D5F
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CRYO-EM RECONSTRUCTION OF MEMBRANE-ENVELOPED FILAMENTOUS VIRUS SFV1 (SULFOLOBUS FILAMENTOUS VIRUS 1)
分子名称:Fimbrial protein, DNA (336-MER)
著者Wang, F., Osinski, T., Liu, Y., Krupovic, M., Prangishvili, D., Egelman, E.H.
登録日2018-04-19
公開日2018-08-29
最終更新日2018-09-12
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile.
Nat Commun, 9, 2018
6DKL
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CRYSTAL STRUCTURE OF A RATIONALLY DESIGNED SIX-FOLD SYMMETRIC DNA SCAFFOLD
分子名称:DNA (5'-D(P*GP*GP*AP*TP*GP*CP*AP*CP*A)-3'), DNA (5'-D(P*CP*AP*CP*AP*CP*CP*GP*TP*AP*C)-3'), DNA (5'-D(P*TP*GP*TP*GP*CP*TP*GP*TP*GP*CP*T)-3'), ...
著者Simmons, C.R., Zhang, F., Yan, H.
登録日2018-05-29
公開日2018-08-29
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (3.034 Å)
主引用文献Self-Assembly of a 3D DNA Crystal Structure with Rationally Designed Six-Fold Symmetry.
Angew. Chem. Int. Ed. Engl., 57, 2018
6EIF
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DYRK1A IN COMPLEX WITH XMD7-117
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIJ
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DYRK1A IN COMPLEX WITH HG-8-60-1
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIL
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DYRK1A IN COMPLEX WITH XMD8-49
分子名称:DYRK1A, [3-azanyl-6-(5-azanyl-2-methoxy-phenyl)pyrazin-2-yl]-pyridin-3-yl-methanone
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.465 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIP
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DYRK1A IN COMPLEX WITH XMD8-62E
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-[[(3~{R},7~{S})-2-cyclopentyl-9-methyl-8-oxidanylidene-2,9,12,14-tetrazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),10,12-trien-13-yl]amino]benzamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIQ
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DYRK1A IN COMPLEX WITH XMD14-124
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, [4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]-phenyl-methanone
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIR
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DYRK1A IN COMPLEX WITH XMD15-27-2
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[4-[[4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIS
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DYRK1A IN COMPLEX WITH JWC-055
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 1-[4-fluoranyl-2-(trifluoromethyl)phenyl]-9-(1~{H}-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2-one
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EIV
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DYRK1A IN COMPLEX WITH JWD-065
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide
著者Rothweiler, U.
登録日2017-09-19
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6EJ4
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DYRK1A IN COMPLEX WITH XMD7-112
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 3-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)aniline
著者Rothweiler, U.
登録日2017-09-20
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
J. Med. Chem., 61, 2018
6C4X
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMMEM
分子名称:cross-alpha amyloid-like membrane peptide alpha-AmMEM, (4S)-2-METHYL-2,4-PENTANEDIOL, ZINC ION
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C4Y
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMG
分子名称:Cross-alpha Amyloid-like Structure alphaAmG
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C4Z
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMG - LOW RESOLUTION
分子名称:Cross-alpha Amyloid-like Structure alphaAmG - low resolution
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C50
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMS
分子名称:Cross-alpha Amyloid-like Structure alphaAmS, FORMIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C51
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAML
分子名称:Cross-alpha Amyloid-like Structure alphaAmL, PHOSPHATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C52
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHATET
分子名称:Cross-alpha Amyloid-like Structure alphaTet, GLYCEROL
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
5YYL
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STRUCTURE OF MAJOR ROYAL JELLY PROTEIN 1 OLIGOMER
分子名称:Major royal jelly protein 1, Apisimin, N-ACETYL-D-GLUCOSAMINE, ...
著者Tian, W., Chen, Z.
登録日2017-12-10
公開日2018-08-08
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun, 9, 2018
5Z2M
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STRUCTURE OF ORP1L/RAB7 COMPLEX
分子名称:Oxysterol-binding protein-related protein 1, Ras-related protein Rab-7a, MAGNESIUM ION, ...
著者Ma, X.L., Liu, K., Li, J., Li, H.H., Li, J., Yang, C.L., Liang, H.H.
登録日2018-01-03
公開日2018-08-08
最終更新日2018-09-19
実験手法X-RAY DIFFRACTION (2.142 Å)
主引用文献A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning.
J. Biol. Chem., 293, 2018