Author results

6J07
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CRYSTAL STRUCTURE OF HUMAN TERB2 AND TERB1
Descriptor:Telomere repeats-binding bouquet formation protein 2, Telomere repeats-binding bouquet formation protein 1, ZINC ION
Authors:Wang, Y., Chen, Y., Wu, J., Huang, C., Lei, M.
Deposit date:2018-12-21
Release date:2019-02-27
Method:X-RAY DIFFRACTION (3.298 Å)
Cite:The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
6J08
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CRYSTAL STRUCTURE OF HUMAN MAJIN AND TERB2
Descriptor:Membrane-anchored junction protein, Telomere repeats-binding bouquet formation protein 2
Authors:Wang, Y., Chen, Y., Wu, J., Huang, C., Lei, M.
Deposit date:2018-12-21
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
6J0V
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CRYSTAL STRUCTURE OF YEAST RTT107
Descriptor:Regulator of Ty1 transposition protein 107
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.314 Å)
Cite:The molecular mechanism of tetra-BRCT and multi-client interactions and its broad impact on genome functions
To be published
6J0W
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CRYSTAL STRUCTURE OF YEAST RTT107 AND NSE6
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from DNA repair protein KRE29
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The molecular mechanism of tetra-BRCT and multi-client interactions and its broad impact on genome functions
To be published
6J0X
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CRYSTAL STRUCTURE OF YEAST RTT107 AND MMS22
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The molecular mechanism of tetra-BRCT and multi-client interactions and its broad impact on genome functions
To be published
6J0Y
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CRYSTAL STRUCTURE OF YEAST RTT107 AND SLX4
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from Structure-specific endonuclease subunit SLX4
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The molecular mechanism of tetra-BRCT and multi-client interactions and its broad impact on genome functions
To be published
6J67
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CRYSTAL STRUCTURE OF THE COMPOUND 34 IN A COMPLEX WITH TRF2
Descriptor:Telomeric repeat-binding factor 2, 3FB-PHE-B8R-LEU-5XU-PRO
Authors:Chen, Y., Yang, Y., Lei, M.
Deposit date:2019-01-14
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction.
ACS Med Chem Lett, 9, 2018
6MLC
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PHD6 DOMAIN OF MLL3 IN COMPLEX WITH HISTONE H4
Descriptor:Histone-lysine N-methyltransferase 2C, Histone H4, ZINC ION, ...
Authors:Dong, A., Liu, Y., Qin, S., Lei, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-10-24
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
6BPH
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CRYSTAL STRUCTURE OF THE CHROMODOMAIN OF RBBP1
Descriptor:AT-rich interactive domain-containing protein 4A, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-11-23
Release date:2017-12-20
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of chromo barrel domain of RBBP1.
Biochem. Biophys. Res. Commun., 496, 2018
2RGX
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CRYSTAL STRUCTURE OF ADENYLATE KINASE FROM AQUIFEX AEOLICUS IN COMPLEX WITH AP5A
Descriptor:Adenylate kinase, ZINC ION, BIS(ADENOSINE)-5'-PENTAPHOSPHATE
Authors:Thai, V., Wolf-Watz, M., Fenn, T., Pozharski, E., Wilson, M.A., Petsko, G.A., Kern, D.
Deposit date:2007-10-05
Release date:2007-12-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Intrinsic motions along an enzymatic reaction trajectory.
Nature, 450, 2007
2RH5
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STRUCTURE OF APO ADENYLATE KINASE FROM AQUIFEX AEOLICUS
Descriptor:Adenylate kinase
Authors:Thai, V., Wolf-Watz, M., Fenn, T., Pozharski, E., Wilson, M.A., Petsko, G.A., Kern, D.
Deposit date:2007-10-05
Release date:2007-12-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Intrinsic motions along an enzymatic reaction trajectory.
Nature, 450, 2007
3D0Z
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STRUCTURAL CHARCATERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
Authors:Sagermann, M.
Deposit date:2008-05-02
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
6J99
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CRYO-EM STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH AN H2B-MONOUBIQUITINATED NUCLEOSOME
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Yao, T., Huang, J.
Deposit date:2019-01-22
Release date:2019-02-27
Last modified:2019-04-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome.
Cell Res., 29, 2019
6KIU
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CRYO-EM STRUCTURE OF HUMAN MLL1-UBNCP COMPLEX (3.2 ANGSTROM)
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
6KIV
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CRYO-EM STRUCTURE OF HUMAN MLL1-UBNCP COMPLEX (4.0 ANGSTROM)
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
6KIW
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CRYO-EM STRUCTURE OF HUMAN MLL3-UBNCP COMPLEX (4.0 ANGSTROM)
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
6KIX
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CRYO-EM STRUCTURE OF HUMAN MLL1-NCP COMPLEX, BINDING MODE1
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
6KIZ
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CRYO-EM STRUCTURE OF HUMAN MLL1-NCP COMPLEX, BINDING MODE2
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Huang, J., Xue, H., Yao, T.
Deposit date:2019-07-20
Release date:2019-09-11
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
2HY8
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PAK1 COMPLEX WITH ST2001
Descriptor:Serine/threonine-protein kinase PAK 1, (5S,6R,7R,9R)-12-HYDROXY-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE
Authors:Schulze-Gahmen, U., Lu, H.
Deposit date:2006-08-04
Release date:2006-11-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Complex Between Human Pak1-kinase and 3-Hydroxystaurosporine
To be Published
4NW3
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CRYSTAL STRUCTURE OF MLL CXXC DOMAIN IN COMPLEX WITH A CPG DNA
Descriptor:Histone-lysine N-methyltransferase 2A, 5'-D(*GP*CP*CP*AP*TP*CP*GP*AP*TP*GP*GP*C)-3', ZINC ION
Authors:Bian, C., Tempel, W., Chao, X., Walker, J.R., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-12-05
Release date:2014-04-23
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4O64
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ZINC FINGERS OF KDM2B
Descriptor:Lysine-specific demethylase 2B, ZINC ION, UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-12-20
Release date:2014-04-16
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4PZI
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ZINC FINGER REGION OF MLL2 IN COMPLEX WITH CPG DNA
Descriptor:Histone-lysine N-methyltransferase 2B, DNA (5'-D(*GP*CP*CP*AP*CP*CP*GP*GP*TP*GP*GP*C)-3'), ZINC ION, ...
Authors:Chao, X., Tempel, W., Liu, K., Dong, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2014-03-31
Release date:2014-06-04
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4QQG
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CRYSTAL STRUCTURE OF AN N-TERMINAL HTATIP FRAGMENT
Descriptor:Histone acetyltransferase KAT5, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Wernimont, A.K., Dobrovetsky, E., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-07-09
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and histone binding studies of the chromo barrel domain of TIP60.
FEBS Lett., 592, 2018
4WVS
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN COMPLEXED WITH (S)-3-(4-METHOXYPHENYL)-2-((S)-2-((S)-1-((S)-2-((S)-2-(METHYLAMINO)PROPANAMIDO)PENT-4-YNOYL)PYRROLIDINE-2-CARBOXAMIDO)-3-PHENYLPROPANAMIDO)PROPANOIC ACID
Descriptor:E3 ubiquitin-protein ligase XIAP, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, ZINC ION, ...
Authors:Pokross, M.E.
Deposit date:2014-11-07
Release date:2015-05-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
J.Med.Chem., 58, 2015
4WVT
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN COMPLEXED WITH LIGAND BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, ZINC ION
Authors:Pokross, M.E.
Deposit date:2014-11-07
Release date:2015-03-04
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
J.Med.Chem., 58, 2015