Author results

6R7Y
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CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (LOW CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
6R7Z
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CRYOEM STRUCTURE OF CALCIUM-FREE HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (CLOSED FORM)
Descriptor:Anoctamin-10
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Last modified:2019-05-15
Method:ELECTRON MICROSCOPY (5.14 Å)
Cite:CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
4CRS
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HUMAN PROTEIN KINASE N2 (PKN2, PRKCL2) IN COMPLEX WITH ATPGAMMAS
Descriptor:SERINE/THREONINE-PROTEIN KINASE N2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Mathea, S., Elkins, J.M., Shrestha, L., Szklarz, M., Tallant, C., Newman, J.A., Cooper, C.D., Shrestha, B., Tumber, A., Cocking, R., Salah, E., von Delft, F., Arrowsmith, C., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2014-02-28
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of Pkn2
To be Published
5HES
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HUMAN LEUCINE ZIPPER- AND STERILE ALPHA MOTIF-CONTAINING KINASE (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) IN COMPLEX WITH VEMURAFENIB
Descriptor:Mitogen-activated protein kinase kinase kinase MLT, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide, 1,2-ETHANEDIOL
Authors:Mathea, S., Salah, E., Abdul Azeez, K.R., Tallant, C., Szklarz, M., Chaikuad, A., Shrestha, B., Sorrell, F.J., Elkins, J.M., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2016-01-06
Release date:2016-03-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.
Acs Chem.Biol., 11, 2016
4BW5
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1)
Descriptor:POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ...
Authors:Pike, A.C.W., Dong, Y.Y., Dong, L., Quigley, A., Shrestha, L., Mukhopadhyay, S., Strain-Damerell, C., Goubin, S., Grieben, M., Shintre, C.A., Mackenzie, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2013-06-30
Release date:2013-07-31
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015
2P6X
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CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE PTPN22
Descriptor:Tyrosine-protein phosphatase non-receptor type 22, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Ugochukwu, E., Salah, E., Barr, A., Shrestha, L., Alfano, I., Burgess-Brown, N., King, O., Umeano, C., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Turnbull, A., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2UZC
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STRUCTURE OF HUMAN PDLIM5 IN COMPLEX WITH THE C-TERMINAL PEPTIDE OF HUMAN ALPHA-ACTININ-1
Descriptor:PDZ AND LIM DOMAIN 5, CHLORIDE ION, 1,2-ETHANEDIOL
Authors:Bunkoczi, G., Elkins, J., Salah, E., Burgess-Brown, N., Papagrigoriou, E., Pike, A.C.W., Turnbull, A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Doyle, D.
Deposit date:2007-04-27
Release date:2007-05-08
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Protein Sci., 19, 2010
2V7O
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CRYSTAL STRUCTURE OF HUMAN CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE II GAMMA
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II GAMMA CHAIN, BISINDOLYLMALEIMIDE IX, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Burgess-Brown, N., Shrestha, L., Ugochukwu, E., Pilka, E.S., von Delft, F., Edwards, A., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Knapp, S.
Deposit date:2007-07-31
Release date:2007-09-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
2VZ6
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STRUCTURE OF HUMAN CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA (CAMK2A) IN COMPLEX WITH INDIRUBIN E804
Descriptor:CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, S-1,2-PROPANEDIOL
Authors:Pike, A.C.W., Rellos, P., King, O., Salah, E., Parizotto, E., Fedorov, O., Shrestha, L., Burgess-Brown, N., Roos, A., Murray, J.W., von Delft, F., Edwards, A., Arrowsmith, C.H., Wikstroem, M., Bountra, C., Knapp, S.
Deposit date:2008-07-30
Release date:2008-08-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
2W2C
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STRUCTURE OF THE TETRADECAMERIC OLIGOMERISATION DOMAIN OF CALCIUM- CALMODULIN DEPENDENT PROTEIN KINASE II DELTA
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN, ACETATE ION, CADMIUM ION
Authors:Pike, A.C.W., Rellos, P., Sethi, R., Salah, E., Burgess-Brown, N., Shrestha, L., Roos, A., Murray, J.W., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2008-10-28
Release date:2008-12-23
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
2W7R
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STRUCTURE OF THE PDZ DOMAIN OF HUMAN MICROTUBULE ASSOCIATED SERINE- THREONINE KINASE 4
Descriptor:MICROTUBULE-ASSOCIATED SERINE/THREONINE-PROTEIN KINASE 4, PHOSPHATE ION
Authors:Muniz, J.R.C., Elkins, J., Wang, J., Savitzky, P., Roos, A., Salah, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2008-12-24
Release date:2009-05-12
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unusual Binding Interactions in Pdz Domain Crystal Structures Help Explain Binding Mechanisms.
Protein Sci., 19, 2010
3K2L
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CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2 (DYRK2)
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 2, SULFATE ION, SODIUM ION, ...
Authors:Filippakopoulos, P., Myrianthopoulos, V., Soundararajan, M., Krojer, T., Hapka, E., Fedorov, O., Berridge, G., Wang, J., Shrestha, L., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Mikros, E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-09-30
Release date:2009-10-13
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Structure, 21, 2013
3ZDQ
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (NUCLEOTIDE-FREE FORM)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL, GLYCINE, ...
Authors:Pike, A.C.W., Shintre, C.A., Krojer, T., von Delft, F., Vollmar, M., Mukhopadhyay, S., Burgess-Brown, N., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-11-30
Release date:2013-01-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
3ZLI
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CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY
Descriptor:HISTONE DEMETHYLASE UTY, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ...
Authors:Vollmar, M., Gileadi, C., Shrestha, L., Goubin, S., Johansson, C., Krojer, T., Raynor, J.W., Bradley, A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
Deposit date:2013-01-31
Release date:2013-02-27
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Uty(Kdm6C) is a Male-Specific Nepsilon-Methyl Lysyl Demethylase.
J.Biol.Chem., 289, 2014
3ZP5
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CRYSTAL STRUCTURE OF THE DNA BINDING ETS DOMAIN OF THE HUMAN PROTEIN FEV IN COMPLEX WITH DNA
Descriptor:PROTEIN FEV, 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3'
Authors:Newman, J.A., Cooper, C.D.O., Krojer, T., Shrestha, L., Allerston, C.K., Vollmar, M., Arrowsmith, C.H., Burgess-Brown, N., Edwards, A., von Delft, F., Gileadi, O.
Deposit date:2013-02-26
Release date:2013-03-06
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
3ZPO
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CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY WITH BOUND GSK J1
Descriptor:HISTONE DEMETHYLASE UTY, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ZINC ION, ...
Authors:Vollmar, M., Gileadi, C., Shrestha, L., Goubin, S., Johansson, C., Krojer, T., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human Uty(Kdm6C) is a Male-Specific Nepislon-Methyl Lysyl Demethylase.
J.Biol.Chem., 289, 2014
4BKN
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HUMAN DIHYDROPYRIMIDINASE-RELATED PROTEIN 3 (DPYSL3)
Descriptor:DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
Authors:Mathea, S., Elkins, J.M., Alegre-Abarrategui, J., Shrestha, L., Burgess-Brown, N., Puranik, S., Coutandin, D., Bradley, A., Vollmar, M., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2013-04-26
Release date:2013-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Dpysl3
To be Published
4BKW
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CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMAN ZFYVE9
Descriptor:ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9, 1,2-ETHANEDIOL, TETRAETHYLENE GLYCOL
Authors:Williams, E., Krojer, T., Vollmar, M., Shrestha, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2013-04-30
Release date:2013-05-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal Structure of the C-Terminal Region of Human Zfyve9
Ph D Thesis, 2013
4CO8
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STRUCTURE OF THE DNA BINDING ETS DOMAIN OF HUMAN ETV4
Descriptor:ETS TRANSLOCATION VARIANT 4, 1,2-ETHANEDIOL
Authors:Newman, J.A., Cooper, C.D.O., Shrestha, L., Burgess-Brown, N., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O.
Deposit date:2014-01-27
Release date:2014-02-05
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4D0N
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AKAP13 (AKAP-LBC) RHOGEF DOMAIN IN COMPLEX WITH RHOA
Descriptor:TRANSFORMING PROTEIN RHOA, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
4D0O
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AKAP13 (AKAP-LBC) DH DOMAIN
Descriptor:A-KINASE ANCHOR PROTEIN 13
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
4I1T
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CRYSTAL STRUCTURE OF THE CAP-SNATCHING ENDONUCLEASE FROM PICHINDE VIRUS
Descriptor:RNA-directed RNA polymerase L
Authors:Bussetta, C., Choi, K.H.
Deposit date:2012-11-21
Release date:2014-02-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the cap-snatching endonuclease from Pichinde virus, a new world arenavirus
To be Published
4TLG
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CRYSTAL STRUCTURE OF SEC14-LIKE PROTEIN 4 (SEC14L4)
Descriptor:SEC14-like protein 4, 1,2-ETHANEDIOL, UNDECANOIC ACID
Authors:Vollmar, M., Kopec, J., Kiyani, W., Shrestha, L., Sorrell, F., Krojer, T., Williams, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-05-29
Release date:2014-07-02
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of SEC14-like protein 4 (SEC14L4)
To Be Published
4UML
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CRYSTAL STRUCTURE OF GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2 (GDAP2) MACRO DOMAIN
Descriptor:GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2
Authors:Elkins, J.M., Wang, J., Kopec, J., Wang, D., Strain-Damerell, C., Shrestha, L., Sieg, C., Tallant, C., Newman, J.A., von Delft, F., Bountra, C., Edwards, A., Knapp, S.
Deposit date:2014-05-19
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Gdap2
To be Published
4UNO
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CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETV5 IN COMPLEX WITH DNA
Descriptor:ETS TRANSLOCATION VARIANT 5, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3', ...
Authors:Newman, J.A., Aitkenhead, H., Cooper, C.D.O., Pinkas, D.M., Shrestha, L., Burgess-Brown, N., Kopec, J., Fitzpatrick, F., Tallant, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2014-05-29
Release date:2014-06-11
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015