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5L0G
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HUMAN METAVINCULIN MVT Q971R, R975D, T978R MUTANT (RESIDUES 959-1134) IN COMPLEX WITH PIP2
Descriptor:Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0H
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HUMAN METAVINCULIN MVT CARDIOMYOPATHY-ASSOCIATED MUTANT R975W (RESIDUES 959-1134) IN COMPLEX WITH PIP2
Descriptor:Vinculin, DI(HYDROXYETHYL)ETHER, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ...
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0I
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HUMAN METAVINCULIN MVT R975W CARDIOMYOPATHY-ASSOCIATED MUTANT (RESIDUES 959-1134)
Descriptor:Vinculin, GLYCEROL, SODIUM ION
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0J
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HUMAN VINCULIN R903Q, D907R, R910T MUTANT(RESIDUES 891-1066)
Descriptor:Vinculin
Authors:Chinthalapudi, K., Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (4 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5TLD
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE PHENYLAMINO-SUBSTITUTED ESTROGEN, (8R,9S,13S,14S,17S)-13-METHYL-17-(PHENYLAMINO)-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-3-OL
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLF
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE CONSTRAINED WAY DERIVATIVE, 4-(2-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3-YL)BENZENE-1,3-DIOL
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 4-[2-(3-methylbut-2-en-1-yl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzene-1,3-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLG
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH (E)-4,4''-DIHYDROXY-3'-((HYDROXYIMINIO)METHYL)-[1,1':2',1''-TERPHENYL]-4'-OLATE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 2~3~-[(E)-(hydroxyimino)methyl][1~1~,2~1~:2~2~,3~1~-terphenyl]-1~4~,2~4~,3~4~-triol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.228 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLL
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH (E)-2-CHLORO-4'-HYDROXY-4-((HYDROXYIMINIO)METHYL)-[1,1'-BIPHENYL]-3-OLATE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 2-chloro-4-[(E)-(hydroxyimino)methyl][1,1'-biphenyl]-3,4'-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.423 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLM
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 4,4',4''-(THIOPHENE-2,3,5-TRIYL)TRIPHENOL
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 4,4',4''-(thiene-2,3,5-triyl)triphenol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLO
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH A SQUARIC ACID-LINKED DIMERIC ESTROGEN
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, (14beta,17alpha)-21-(4-aminophenyl)-19-norpregna-1(10),2,4-trien-20-yne-3,17-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLP
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-BSC ANALOG, 3-FLUOROPHENYL (1R,2R,4S)-5-(4-HYDROXYPHENYL)-6-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2-SULFONATE AND 3-METHYL-6-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-AMINE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 3-methyl-6-phenyl-3H-imidazo[4,5-b]pyridin-2-amine, ...
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLT
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH OCTANE-1,8-DIYL BIS(2,3-BIS(4-HYDROXYPHENYL)PENTANOATE)
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 8-{[2,3-bis(4-hydroxyphenyl)pentanoyl]oxy}octyl (2R,3S)-2,3-bis(4-hydroxyphenyl)pentanoate
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLU
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE PEG-LINKED DIMERIC ESTROGEN, EE2-(EG)6-EE2-AMINE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, (14beta,17alpha)-21-(4-aminophenyl)-19-norpregna-1(10),2,4-trien-20-yne-3,17-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.223 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLV
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 4,4'-(THIOPHENE-2,3-DIYL)BIS(3-FLUOROPHENOL)
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 4,4'-(thiene-2,3-diyl)bis(3-fluorophenol)
Authors:Nwachukwu, J.C., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLX
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 3,4-BIS(4-HYDROXYPHENYL)THIOPHENE 1,1-DIOXIDE
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 3-methyl-6-phenyl-3H-imidazo[4,5-b]pyridin-2-amine, ...
Authors:Nwachukwu, J.C., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLY
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 3,4-BIS(2-FLUORO-4-HYDROXYPHENYL)THIOPHENE 1,1-DIOXIDE
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 3,4-bis(2-fluoro-4-hydroxyphenyl)-1H-1lambda~6~-thiophene-1,1-dione
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.143 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM1
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 2,5-BIS(2-FLUORO-4-HYDROXYPHENYL)THIOPHENE 1-OXIDE
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 2,5-bis(2-fluoro-4-hydroxyphenyl)-1H-1lambda~4~-thiophen-1-one
Authors:Nwachukwu, J.C., Wright, N.J., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM2
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 2,5-BIS(2-CHLORO-4-HYDROXYPHENYL)THIOPHENE 1-OXIDE
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 2,5-bis(2-chloro-4-hydroxyphenyl)-1H-1lambda~4~-thiophen-1-one
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM3
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 2,3-BIS(2-CHLORO-4-HYDROXYPHENYL)THIOPHENE 1-OXIDE
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, (1S)-2,3-bis(2-chloro-4-hydroxyphenyl)-1H-1lambda~4~-thiophen-1-one
Authors:Nwachukwu, J.C., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM4
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-ASC ANALOG, 5-(4-((1R,4S,6R)-6-((3-CHLOROPHENOXY)SULFONYL)-3-(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-2-EN-2-YL)PHENOXY)PENTANOIC ACID
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 5-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}pentanoic acid
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM5
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-ASC COMPOUND, 5-(4-((1R,4S,6R)-6-((4-BROMOPHENOXY)SULFONYL)-3-(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-2-EN-2-YL)PHENOXY)PENTANOIC ACID
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 5-{4-[(1S,4S,5R)-5-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}pentanoic acid
Authors:Nwachukwu, J.C., Wright, N.J., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM6
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-ASC COMPOUND, 6-(4-((1R,4S,6R)-6-((4-BROMOPHENOXY)SULFONYL)-3-(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-2-EN-2-YL)PHENOXY)HEXANOIC ACID
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 6-{4-[(1S,4S,6R)-6-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}hexanoic acid
Authors:Nwachukwu, J.C., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.542 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM7
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-ASC COMPOUND, 7-(4-((1R,4S,6R)-6-((3-CHLOROPHENOXY)SULFONYL)-3-(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-2-EN-2-YL)PHENOXY)HEPTANOIC ACID
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 7-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}heptanoic acid
Authors:Nwachukwu, J.C., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM8
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-ASC COMPOUND, 7-(4-((1R,4S,6R)-6-((4-BROMOPHENOXY)SULFONYL)-3-(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-2-EN-2-YL)PHENOXY)HEPTANOIC ACID
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 7-{4-[(1S,4S,6R)-6-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}heptanoic acid
Authors:Nwachukwu, J.C., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TM9
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-ASC ANALOG, (E)-3-(4-((1R,4S,6R)-6-((3-CHLOROPHENOXY)SULFONYL)-3-(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-2-EN-2-YL)PHENYL)ACRYLIC ACID
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 3-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}prop-2-enoic acid
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017