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4CX3
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE M336V D597N MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL) PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX4
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE M336V D597N MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4-((5-(4- METHYLPYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX5
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE H341L MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL) PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX6
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE H341L MUTANT HEME DOMAIN IN COMPLEX WITH 6-((((3S, 5R)-5-(((6-AMINO-4-METHYLPYRIDIN-2- YL)METHOXY)METHYL)PYRROLIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
4CX7
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STRUCTURE OF HUMAN INOS HEME DOMAIN IN COMPLEX WITH (R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, INDUCIBLE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-04-03
Release date:2014-08-13
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.
Biochemistry, 53, 2014
5HK8
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CRYSTAL STRUCUTRE OF A METHYLESTERASE PROTEIN MES16 FROM ARABIDOPSIS
Descriptor:Probable pheophorbidase
Authors:Li, H., Pu, H.
Deposit date:2016-01-13
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal strucutre of a methylesterase protein MES16 from Arabidopsis
Biochem.Biophys.Res.Commun., 2016
5K16
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CRYSTAL STRUCTURE OF FREE UBIQUITIN-SPECIFIC PROTEASE 12
Descriptor:Ubiquitin carboxyl-terminal hydrolase 12, ZINC ION, GLYCEROL
Authors:Li, H., D'Andrea, A.D., Zheng, N.
Deposit date:2016-05-17
Release date:2016-07-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5K19
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CRYSTAL STRUCTURE OF WD REPEAT-CONTAINING PROTEIN 20
Descriptor:WD repeat-containing protein 20, SULFATE ION, GLYCEROL
Authors:Li, H., D'Andrea, A.D., Zheng, N.
Deposit date:2016-05-17
Release date:2016-07-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5K1A
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CRYSTAL STRUCTURE OF THE UAF1-USP12 COMPLEX IN C2 SPACE GROUP
Descriptor:Ubiquitin carboxyl-terminal hydrolase 12, WD repeat-containing protein 48, ZINC ION
Authors:Li, H., D'Andrea, A.D., Zheng, N.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5K1B
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CRYSTAL STRUCTURE OF THE UAF1/USP12 COMPLEX IN F222 SPACE GROUP
Descriptor:WD repeat-containing protein 48, Ubiquitin carboxyl-terminal hydrolase 12, ZINC ION
Authors:Li, H., D'Andrea, A.D., Zheng, N.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5K1C
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CRYSTAL STRUCTURE OF THE UAF1/WDR20/USP12 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 12, WD repeat-containing protein 48, WD repeat-containing protein 20, ...
Authors:Li, H., D'Andrea, A.D., Zheng, N.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5XPY
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STRUCTURAL BASIS OF KINDLIN-MEDIATED INTEGRIN RECOGNITION AND ACTIVATION
Descriptor:Fermitin family homolog 2, ACETATE ION, GLYCEROL
Authors:Li, H., Yang, H., Sun, K., Zhang, Z., Yu, C., Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XPZ
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STRUCTURAL BASIS OF KINDLIN-MEDIATED INTEGRIN RECOGNITION AND ACTIVATION
Descriptor:Fermitin family homolog 2, GLYCEROL
Authors:Li, H., Yang, H., Sun, K., Zhang, Z., Yu, C., Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XQ0
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STRUCTURAL BASIS OF KINDLIN-MEDIATED INTEGRIN RECOGNITION AND ACTIVATION
Descriptor:Fermitin family homolog 2,Integrin beta-1, GLYCEROL
Authors:Li, H., Yang, H., Sun, K., Zhang, Z., Yu, C., Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XQ1
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STRUCTURAL BASIS OF KINDLIN-MEDIATED INTEGRIN RECOGNITION AND ACTIVATION
Descriptor:Fermitin family homolog 2,Integrin beta-3
Authors:Li, H., Yang, H., Sun, K., Zhang, Z., Yu, C., Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.954 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
9NSE
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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE, ETHYL-ISOSELENOUREA COMPLEX
Descriptor:PROTEIN (NITRIC OXIDE SYNTHASE), ACETATE ION, ZINC ION, ...
Authors:Li, H., Raman, C.S., Martasek, P., Kral, V., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-01-13
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.
J.Inorg.Biochem., 81, 2000
1WWQ
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SOLUTION STRUCTURE OF MOUSE ER
Descriptor:Enhancer of rudimentary homolog
Authors:Li, H., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-01-12
Release date:2006-01-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold
J.Biomol.Nmr, 32, 2005
1X1G
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SOLUTION STRUCTURE OF THE C-TERMINAL PH DOMAIN OF HUMAN PLECKSTRIN 2
Descriptor:Pleckstrin 2
Authors:Li, H., Tomizawa, T., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-04-04
Release date:2005-10-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal PH domain of human pleckstrin 2
To be Published
2HAI
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CRYSTAL STRUCTURE OF HCV NS5B RNA POLYMERASE IN COMPLEX WITH NOVEL CLASS OF DIHYDROPYRONE-CONTAINING INHIBITOR.
Descriptor:HEPATITIS C VIRUS NS5B RNA POLYMERASE, (6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE
Authors:Li, H., Love, R.L.
Deposit date:2006-06-12
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2JW2
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VALIDATION OF INTER-HELICAL ORIENTATION OF THE STERIL-ALPHA-MOTIF OF HUMAN DELETED IN LIVER CANCER 2 BY RESIDUAL DIPOLAR COUPLINGS
Descriptor:StAR-related lipid transfer protein 13
Authors:Li, H., Sze, K., Fung, K.
Deposit date:2007-10-03
Release date:2008-10-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Validation of inter-helical orientation of the steril-alpha-motif of human deleted in liver cancer 2 by residual dipolar couplings
To be Published
2LZX
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SOLUTION NMR STRUCTURE OF ASTEROPSIN B FROM A MARINE SPONGE ASTEROPUS SP.
Descriptor:Asteropsin B
Authors:Li, H., Bowling, J.J., Hamann, M.T., Jung, J.H.
Deposit date:2012-10-11
Release date:2013-10-23
Method:SOLUTION NMR
Cite:Sponge Derived Linear Knottins as a Novel Scaffold for Oral Peptide Drug Administration
To be Published
2LZY
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SOLUTION NMR STRUCTURE OF ASTEROPSIN C FROM A MARINE SPONGE ASTEROPUS SP.
Descriptor:ABU8-3
Authors:Li, H., Bowling, J.J., Hamann, M.T., Jung, J.H.
Deposit date:2012-10-12
Release date:2013-10-23
Method:SOLUTION NMR
Cite:Sponge Derived Linear Knottins as a Novel Scaffold for Oral Peptide Drug Administration
To be Published
3RQJ
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STRUCTURE OF THE NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(((3R,4R)-4-(2-((1S,2R)-2-(3-FLUOROPHENYL)CYCLOPROPYLAMINO)ETHOXY)PYRROLIDIN-3-YL)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2011-04-28
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 21, 2013
3RQK
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STRUCTURE OF THE NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-METHYLPHENYL)CYCLOPROPYL]AMINO}ETHOXY)PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE AND ITS ISOMER
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2011-04-28
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 21, 2013
3RQL
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STRUCTURE OF THE NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(((3R,4R)-4-(2-((1S,2R/1R,2S)-2-(3-CLOROPHENYL)CYCLOPROPYLAMINO)ETHOXY)PYRROLIDIN-3-YL)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2011-04-28
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 21, 2013