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2XM7
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STRUCTURAL AND MECHANISTIC ANALYSIS OF THE MAGNESIUM-INDEPENDENT AROMATIC PRENYLTRANSFERASE CLOQ FROM THE CLOROBIOCIN BIOSYNTHETIC PATHWAY
Descriptor:CLOQ, (2R)-2-HYDROXY-3-(4-HYDROXYPHENYL)PROPANOIC ACID, 1,2-ETHANEDIOL, ...
Authors:Metzger, U., Keller, S., Stevenson, C.E.M., Heide, L., Lawson, D.M.
Deposit date:2010-07-25
Release date:2010-10-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase Cloq from the Clorobiocin Biosynthetic Pathway.
J.Mol.Biol., 404, 2010
2Y2Z
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LIGAND-FREE FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y30
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SIMOCYCLINONE D8 BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE D8, CHLORIDE ION
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y31
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SIMOCYCLINONE C4 BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE C4, PENTAETHYLENE GLYCOL, ...
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
3ZPL
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CRYSTAL STRUCTURE OF SCO3205, A MARR FAMILY TRANSCRIPTIONAL REGULATOR FROM STREPTOMYCES COELICOLOR, IN COMPLEX WITH DNA
Descriptor:PUTATIVE MARR-FAMILY TRANSCRIPTIONAL REPRESSOR, 5'-D(*AP*AP*AP*GP*AP*TP*TP*GP*AP*GP*AP*TP*CP*TP *CP*AP*AP*TP*CP*TP*TP*DT)-3', PHOSPHATE ION
Authors:Stevenson, C.E.M., Assaad, A., Lawson, D.M.
Deposit date:2013-02-28
Release date:2013-07-17
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Investigation of DNA Sequence Recognition by a Streptomycete Marr Family Transcriptional Regulator Through Surface Plasmon Resonance and X-Ray Crystallography.
Nucleic Acids Res., 41, 2013
3ZQL
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DNA-BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*CP*CP*GP*TP*AP*DCP *GP*AP*A)-3', 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*GP*CP*GP*TP*AP*DCP *GP*AP*A)-3'
Authors:Le, T.B.K., Schumacher, M.A., Lawson, D.M., Brennan, R.G., Buttner, M.J.
Deposit date:2011-06-10
Release date:2011-08-31
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The Crystal Structure of the Tetr Family Transcriptional Repressor Simr Bound to DNA and the Role of a Flexible N-Terminal Extension in Minor Groove Binding.
Nucleic Acids Res., 39, 2011
3ZSS
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APO FORM OF GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR
Descriptor:PUTATIVE GLUCANOHYDROLASE PEP1A
Authors:Syson, K., Stevenson, C.E.M., Rejzek, M., Fairhurst, S.A., Nair, A., Bruton, C.J., Field, R.A., Chater, K.F., Lawson, D.M., Bornemann, S.
Deposit date:2011-06-30
Release date:2011-09-14
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a Streptomyces Maltosyltransferase Glge: A Homologue of a Genetically Validated Anti-Tuberculosis Target.
J.Biol.Chem., 286, 2011
3ZST
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GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR WITH ALPHA-CYCLODEXTRIN BOUND
Descriptor:PUTATIVE GLUCANOHYDROLASE PEP1A GLGE ISOFORM 1, ALPHA-CYCLODEXTRIN (CYCLOHEXA-AMYLOSE), 1,2-ETHANEDIOL
Authors:Syson, K., Stevenson, C.E.M., Rejzek, M., Fairhurst, S.A., Nair, A., Bruton, C.J., Field, R.A., Chater, K.F., Lawson, D.M., Bornemann, S.
Deposit date:2011-06-30
Release date:2011-09-14
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a Streptomyces Maltosyltransferase Glge: A Homologue of a Genetically Validated Anti-Tuberculosis Target.
J.Biol.Chem., 286, 2011
3ZT5
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GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR WITH MALTOSE BOUND
Descriptor:PUTATIVE GLUCANOHYDROLASE PEP1A, MALTOSE
Authors:Syson, K., Stevenson, C.E.M., Rejzek, M., Fairhurst, S.A., Nair, A., Bruton, C.J., Field, R.A., Chater, K.F., Lawson, D.M., Bornemann, S.
Deposit date:2011-07-01
Release date:2011-09-14
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure of a Streptomyces Maltosyltransferase Glge: A Homologue of a Genetically Validated Anti-Tuberculosis Target.
J.Biol.Chem., 286, 2011
3ZT6
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GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR WITH ALPHA-CYCLODEXTRIN AND MALTOSE BOUND
Descriptor:PUTATIVE GLUCANOHYDROLASE PEP1A, ALPHA-CYCLODEXTRIN (CYCLOHEXA-AMYLOSE), MALTOSE
Authors:Syson, K., Stevenson, C.E.M., Rejzek, M., Fairhurst, S.A., Nair, A., Bruton, C.J., Field, R.A., Chater, K.F., Lawson, D.M., Bornemann, S.
Deposit date:2011-07-01
Release date:2011-09-14
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure of a Streptomyces Maltosyltransferase Glge: A Homologue of a Genetically Validated Anti-Tuberculosis Target.
J.Biol.Chem., 286, 2011
3ZT7
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GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR WITH BETA-CYCLODEXTRIN AND MALTOSE BOUND
Descriptor:PUTATIVE GLUCANOHYDROLASE PEP1A, BETA-CYCLODEXTRIN, MALTOSE
Authors:Syson, K., Stevenson, C.E.M., Rejzek, M., Fairhurst, S.A., Nair, A., Bruton, C.J., Field, R.A., Chater, K.F., Lawson, D.M., Bornemann, S.
Deposit date:2011-07-01
Release date:2011-09-14
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a Streptomyces Maltosyltransferase Glge: A Homologue of a Genetically Validated Anti-Tuberculosis Target.
J.Biol.Chem., 286, 2011
4B8X
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NEAR ATOMIC RESOLUTION CRYSTAL STRUCTURE OF SCO5413, A MARR FAMILY TRANSCRIPTIONAL REGULATOR FROM STREPTOMYCES COELICOLOR
Descriptor:POSSIBLE MARR-TRANSCRIPTIONAL REGULATOR, CHLORIDE ION
Authors:Holley, T.A., Stevenson, C.E.M., Bibb, M.J., Lawson, D.M.
Deposit date:2012-08-31
Release date:2012-10-17
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:High Resolution Crystal Structure of Sco5413, a Widespread Actinomycete Marr Family Transcriptional Regulator of Unknown Function.
Proteins, 81, 2013
4BQE
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ARABIDOPSIS THALIANA CYTOSOLIC ALPHA-1,4-GLUCAN PHOSPHORYLASE (PHS2)
Descriptor:ALPHA-GLUCAN PHOSPHORYLASE 2,4-GLUCAN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ...
Authors:O'Neill, E.C., Rashid, A.M., Stevenson, C.E.M., Hetru, A.C., Gunning, A.P., Rejzek, M., Nepogodiev, S.A., Bornemann, S., Lawson, D.M., Field, R.A.
Deposit date:2013-05-30
Release date:2014-02-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Sugar-Coated Sensor Chip and Nanoparticle Surfaces for the in Vitro Enzymatic Synthesis of Starch-Like Materials
Chem.Sci., 5, 2014
4BQF
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ARABIDOPSIS THALIANA CYTOSOLIC ALPHA-1,4-GLUCAN PHOSPHORYLASE (PHS2) IN COMPLEX WITH ACARBOSE
Descriptor:ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:O'Neill, E.C., Rashid, A.M., Stevenson, C.E.M., Hetru, A.C., Gunning, A.P., Rejzek, M., Nepogodiev, S.A., Bornemann, S., Lawson, D.M., Field, R.A.
Deposit date:2013-05-30
Release date:2014-02-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Sugar-Coated Sensor Chip and Nanoparticle Surfaces for the in Vitro Enzymatic Synthesis of Starch-Like Materials
Chem.Sci., 5, 2014
4BQI
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ARABIDOPSIS THALIANA CYTOSOLIC ALPHA-1,4-GLUCAN PHOSPHORYLASE (PHS2) IN COMPLEX WITH MALTOTRIOSE
Descriptor:ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:O'Neill, E.C., Rashid, A.M., Stevenson, C.E.M., Hetru, A.C., Gunning, A.P., Rejzek, M., Nepogodiev, S.A., Bornemann, S., Lawson, D.M., Field, R.A.
Deposit date:2013-05-30
Release date:2014-02-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Sugar-Coated Sensor Chip and Nanoparticle Surfaces for the in Vitro Enzymatic Synthesis of Starch-Like Materials
Chem.Sci., 5, 2014
4BWV
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STRUCTURE OF ADENOSINE 5-PRIME-PHOSPHOSULFATE REDUCTASE APR-B FROM PHYSCOMITRELLA PATENS
Descriptor:PHOSPHOADENOSINE-PHOSPHOSULPHATE REDUCTASE, DI(HYDROXYETHYL)ETHER
Authors:Stevenson, C.E.M., Hughes, R.K., McManus, M.T., Lawson, D.M., Kopriva, S.
Deposit date:2013-07-04
Release date:2013-11-27
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The X-Ray Crystal Structure of Apr-B, an Atypical Adenosine 5-Prime-Phosphosulfate Reductase from Physcomitrella Patens
FEBS Lett., 587, 2013
4CKK
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APO STRUCTURE OF 55 KDA N-TERMINAL DOMAIN OF E. COLI DNA GYRASE A SUBUNIT
Descriptor:DNA GYRASE SUBUNIT A
Authors:Hearnshaw, S.J., Edwards, M.J., Stevenson, C.E.M., Lawson, D.M., Maxwell, A.
Deposit date:2014-01-07
Release date:2014-03-12
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition.
J.Mol.Biol., 426, 2014
4CKL
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STRUCTURE OF 55 KDA N-TERMINAL DOMAIN OF E. COLI DNA GYRASE A SUBUNIT WITH SIMOCYCLINONE D8 BOUND
Descriptor:DNA GYRASE SUBUNIT A, SIMOCYCLINONE D8
Authors:Hearnshaw, S.J., Edwards, M.J., Stevenson, C.E.M., Lawson, D.M., Maxwell, A.
Deposit date:2014-01-07
Release date:2014-03-12
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition.
J.Mol.Biol., 426, 2014
4CN1
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GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR D394A MUTANT WITH MALTOSE- 1-PHOSPHATE BOUND
Descriptor:ALPHA-1,4-GLUCAN\: MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE 1, alpha-maltose 1-phosphate
Authors:Syson, K., Stevenson, C.E.M., Rashid, A.M., Saalbach, G., Tang, M., Tuukanen, A., Svergun, D.I., Withers, S.G., Lawson, D.M., Bornemann, S.
Deposit date:2014-01-21
Release date:2014-05-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Insight Into How Streptomyces Coelicolor Maltosyl Transferase Glge Binds Alpha-Maltose 1-Phosphate and Forms a Maltosyl-Enzyme Intermediate.
Biochemistry, 53, 2014
4CN4
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GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR E423A MUTANT WITH 2-DEOXY- 2-FLUORO-BETA-MALTOSYL MODIFICATION
Descriptor:ALPHA-1,4-GLUCAN\:MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE 1, 2-deoxy-2-fluoro-beta-D-glucopyranose, ALPHA-D-GLUCOSE
Authors:Syson, K., Stevenson, C.E.M., Rashid, A.M., Saalbach, G., Tang, M., Tuukanen, A., Svergun, D.I., Withers, S.G., Lawson, D.M., Bornemann, S.
Deposit date:2014-01-21
Release date:2014-05-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Insight Into How Streptomyces Coelicolor Maltosyl Transferase Glge Binds Alpha-Maltose 1-Phosphate and Forms a Maltosyl-Enzyme Intermediate.
Biochemistry, 53, 2014
4CN6
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GLGE ISOFORM 1 FROM STREPTOMYCES COELICOLOR E423A MUTANT WITH MALTOSE BOUND
Descriptor:ALPHA-1,4-GLUCAN\:MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE 1, 4-O-alpha-D-Glucopyranosyl-beta-D-glucopyranose
Authors:Syson, K., Stevenson, C.E.M., Rashid, A.M., Saalbach, G., Tang, M., Tuukanen, A., Svergun, D.I., Withers, S.G., Lawson, D.M., Bornemann, S.
Deposit date:2014-01-21
Release date:2014-05-21
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural Insight Into How Streptomyces Coelicolor Maltosyl Transferase Glge Binds Alpha-Maltose 1-Phosphate and Forms a Maltosyl-Enzyme Intermediate.
Biochemistry, 53, 2014
4WUB
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N-TERMINAL 43 KDA FRAGMENT OF THE E. COLI DNA GYRASE B SUBUNIT GROWN FROM 100 MM KCL CONDITION
Descriptor:DNA gyrase subunit B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Hearnshaw, S.J., Chung, T.T., Stevenson, C.E.M., Maxwell, A., Lawson, D.M.
Deposit date:2014-10-31
Release date:2015-04-08
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The role of monovalent cations in the ATPase reaction of DNA gyrase
Acta Crystallogr.,Sect.D, 71, 2015
4WUC
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N-TERMINAL 43 KDA FRAGMENT OF THE E. COLI DNA GYRASE B SUBUNIT GROWN FROM 100 MM NACL CONDITION
Descriptor:DNA gyrase subunit B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Hearnshaw, S.J., Chung, T.T., Stevenson, C.E.M., Maxwell, A., Lawson, D.M.
Deposit date:2014-10-31
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The role of monovalent cations in the ATPase reaction of DNA gyrase
Acta Crystallogr.,Sect.D, 71, 2015
4WUD
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N-TERMINAL 43 KDA FRAGMENT OF THE E. COLI DNA GYRASE B SUBUNIT GROWN FROM NO SALT CONDITION
Descriptor:DNA gyrase subunit B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Hearnshaw, S.J., Chung, T.T., Stevenson, C.E.M., Maxwell, A., Lawson, D.M.
Deposit date:2014-10-31
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The role of monovalent cations in the ATPase reaction of DNA gyrase
Acta Crystallogr.,Sect.D, 71, 2015
4XHC
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RHAMNOSIDASE FROM KLEBSIELLA OXYTOCA WITH RHAMNOSE BOUND
Descriptor:Alpha-L-rhamnosidase, ALPHA-L-RHAMNOSE, SULFATE ION
Authors:O'Neill, E.O., Stevenson, C.E.M., Patterson, M.J., Rejzek, M., Chauvin, A., Lawson, D.M., Field, R.A.
Deposit date:2015-01-05
Release date:2015-04-15
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a novel two domain GH78 family alpha-rhamnosidase from Klebsiella oxytoca with rhamnose bound.
Proteins, 83, 2015