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1MQ3
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BU of 1mq3 by Molmil
Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine Template Paired with dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Krahn, J.M, Beard, W.A, Miller, H, Grollman, A.P, Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1MQ2
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BU of 1mq2 by Molmil
Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine and dAMP
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3', ...
Authors:Krahn, J.M, Beard, W.A, Miller, H, Grollman, A.P, Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1ECB
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BU of 1ecb by Molmil
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE COMPLEXED WITH 2 GMP, 1 MG PER SUBUNIT
Descriptor: GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION
Authors:Krahn, J.M, Smith, J.L.
Deposit date:1997-07-15
Release date:1998-04-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Biochemistry, 36, 1997
1ECC
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BU of 1ecc by Molmil
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE COMPLEXED WITH MN-CPRPP AND 5-OXO-NORLEUCINE
Descriptor: 1-ALPHA-PYROPHOSPHORYL-2-ALPHA,3-ALPHA-DIHYDROXY-4-BETA-CYCLOPENTANE-METHANOL-5-PHOSPHATE, 5-OXO-L-NORLEUCINE, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, ...
Authors:Krahn, J.M, Smith, J.L.
Deposit date:1997-07-09
Release date:1998-04-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Biochemistry, 36, 1997
1TV9
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BU of 1tv9 by Molmil
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE
Descriptor: 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M, Beard, W.M, Wilson, S.H.
Deposit date:2004-06-29
Release date:2004-11-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:STRUCTURAL INSIGHTS INTO DNA POLYMERASE BETA DETERRENTS FOR MISINCORPORATION SUPPORT OF AN INDUCED-FIT MECHANISM FOR FIDELITY
Structure, 12, 2004
1TVA
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BU of 1tva by Molmil
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE
Descriptor: 5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M, Beard, W.A, Wilson, S.H.
Deposit date:2004-06-29
Release date:2004-11-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity
Structure, 12, 2004
2RH2
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BU of 2rh2 by Molmil
High Resolution DHFR R-67
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2
Authors:Krahn, J.M, London, R.E.
Deposit date:2007-10-05
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex
Biochemistry, 46, 2007
2RK1
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BU of 2rk1 by Molmil
DHFR R67 Complexed with NADP and dihydrofolate
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, DIHYDROFOLIC ACID, Dihydrofolate reductase type 2, ...
Authors:Krahn, J.M, London, R.E.
Deposit date:2007-10-16
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
2RK2
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BU of 2rk2 by Molmil
DHFR R-67 complexed with NADP
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Krahn, J.M, London, R.E.
Deposit date:2007-10-16
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
1ECF
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BU of 1ecf by Molmil
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE
Descriptor: GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
Authors:Krahn, J.M.
Deposit date:1996-04-23
Release date:1996-11-08
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli.
Protein Sci., 7, 1998
1ECG
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BU of 1ecg by Molmil
DON INACTIVATED ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE
Descriptor: 5-OXO-L-NORLEUCINE, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
Authors:Krahn, J.M.
Deposit date:1996-04-23
Release date:1996-11-08
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site.
J.Biol.Chem., 271, 1996
4X9E
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BU of 4x9e by Molmil
DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Escherichia coli with two DNA effector molecules
Descriptor: Deoxyguanosinetriphosphate triphosphohydrolase, MAGNESIUM ION, RNA (5'-R(P*CP*CP*C)-3')
Authors:Singh, D, Gawel, D, Itsko, M, Krahn, J.M, London, R.E, Schaaper, R.M.
Deposit date:2014-12-11
Release date:2015-02-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES.
J.Biol.Chem., 290, 2015
4DD8
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BU of 4dd8 by Molmil
ADAM-8 metalloproteinase domain with bound batimastat
Descriptor: 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CALCIUM ION, CHLORIDE ION, ...
Authors:Hall, T, Shieh, H.S, Day, J.E, Caspers, N, Chrencik, J.E, Williams, J.M, Pegg, L.E, Pauley, A.M, Moon, A.F, Krahn, J.M, Fischer, D.H, Kiefer, J.R, Tomasselli, A.G, Zack, M.D.
Deposit date:2012-01-18
Release date:2012-06-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human ADAM-8 catalytic domain complexed with batimastat.
Acta Crystallogr.,Sect.F, 68, 2012
6VCJ
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BU of 6vcj by Molmil
Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen
Descriptor: (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Dihydrofolate reductase, FOLIC ACID, ...
Authors:Pedersen, L.C, London, R.E, Gabel, S.A, Krahn, J.M, DeRose, E.F.
Deposit date:2019-12-21
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
J.Med.Chem., 63, 2020
4XDS
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BU of 4xds by Molmil
Deoxyguanosinetriphosphate Triphosphohydrolase from Escherichia coli with Nickel
Descriptor: Deoxyguanosinetriphosphate triphosphohydrolase, NICKEL (II) ION, SULFATE ION
Authors:Singh, D, Gawel, D, Itsko, M, Krahn, J.M, London, R.E, Schaaper, R.M.
Deposit date:2014-12-19
Release date:2015-02-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.354 Å)
Cite:Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES.
J.Biol.Chem., 290, 2015
5FGW
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BU of 5fgw by Molmil
Structure of Sda1 nuclease with bound zinc ion
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C.
Deposit date:2015-12-21
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes.
Nucleic Acids Res., 44, 2016
5FGU
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BU of 5fgu by Molmil
Structure of Sda1 nuclease apoprotein as an EGFP fixed-arm fusion
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Green fluorescent protein,Extracellular streptodornase D, ...
Authors:Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C.
Deposit date:2015-12-21
Release date:2016-03-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes.
Nucleic Acids Res., 44, 2016
6MAT
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BU of 6mat by Molmil
Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Rix7 mutant, unknown protein
Authors:Lo, Y.H, Sobhany, M, Hsu, A.L, Ford, B.L, Krahn, J.M, Borgnia, M.J, Stanley, R.E.
Deposit date:2018-08-28
Release date:2019-02-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7.
Nat Commun, 10, 2019
4NDZ
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BU of 4ndz by Molmil
Structure of Maltose Binding Protein fusion to 2-O-Sulfotransferase with bound heptasaccharide and PAP
Descriptor: ADENOSINE-3'-5'-DIPHOSPHATE, Maltose-binding periplasmic protein, Heparan sulfate 2-O-sulfotransferase 1 fusion, ...
Authors:Liu, C, Sheng, J, Krahn, J.M, Perera, L, Xu, Y, Hsieh, P, Liu, J, Pedersen, L.C.
Deposit date:2013-10-28
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Deciphering the role of 2-O-sulfotransferase in regulating heparan sulfate biosynthesis
To be Published
6OF2
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BU of 6of2 by Molmil
Precursor ribosomal RNA processing complex, State 2.
Descriptor: CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E.
Deposit date:2019-03-28
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
6OF3
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BU of 6of3 by Molmil
Precursor ribosomal RNA processing complex, State 1.
Descriptor: CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E.
Deposit date:2019-03-28
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
3UAN
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BU of 3uan by Molmil
Crystal structure of 3-O-sulfotransferase (3-OST-1) with bound PAP and heptasaccharide substrate
Descriptor: 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ...
Authors:Moon, A.F, Xu, Y, Woody, S.M, Krahn, J.M, Linhardt, R.J, Liu, J, Pedersen, L.C.
Deposit date:2011-10-21
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.844 Å)
Cite:Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin.
Proc.Natl.Acad.Sci.USA, 109, 2012
6OF4
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BU of 6of4 by Molmil
Precursor ribosomal RNA processing complex, apo-state.
Descriptor: CLP1_P domain-containing protein, Ribonuclease
Authors:Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E.
Deposit date:2019-03-28
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
6Q00
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BU of 6q00 by Molmil
TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 1
Descriptor: POTASSIUM ION, Tyrosyl-DNA phosphodiesterase 2, Ubiquitin
Authors:Schellenberg, M.J, Krahn, J.M, Williams, R.S.
Deposit date:2019-08-01
Release date:2020-04-29
Last modified:2020-06-24
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.
Nucleic Acids Res., 48, 2020
6Q01
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BU of 6q01 by Molmil
TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 2
Descriptor: 1,2-ETHANEDIOL, BENZOIC ACID, MAGNESIUM ION, ...
Authors:Schellenberg, M.J, Krahn, J.M, Williams, R.S.
Deposit date:2019-08-01
Release date:2020-04-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (0.851 Å)
Cite:Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.
Nucleic Acids Res., 48, 2020

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