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1NTP
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BU of 1ntp by Molmil
USE OF THE NEUTRON DIFFRACTION H/D EXCHANGE TECHNIQUE TO DETERMINE THE CONFORMATIONAL DYNAMICS OF TRYPSIN
Descriptor: BETA-TRYPSIN, PHOSPHORYLISOPROPANE
Authors:Kossiakoff, A.A.
Deposit date:1987-09-16
Release date:1988-01-16
Last modified:2017-11-29
Method:NEUTRON DIFFRACTION (1.8 Å)
Cite:Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin
Basic Life Sci., 27, 1984
1TGN
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BU of 1tgn by Molmil
STRUCTURE OF BOVINE TRYPSINOGEN AT 1.9 ANGSTROMS RESOLUTION
Descriptor: TRYPSINOGEN
Authors:Kossiakoff, A.A, Stroud, R.M.
Deposit date:1979-09-19
Release date:1979-10-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of bovine trypsinogen at 1.9 A resolution.
Biochemistry, 16, 1977
3PGF
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BU of 3pgf by Molmil
Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)
Descriptor: GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ...
Authors:Kossiakoff, A.A, Duguid, E.M, Sandstrom, A.
Deposit date:2010-11-01
Release date:2011-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Nat.Struct.Mol.Biol., 18, 2011
1AAL
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BU of 1aal by Molmil
STRUCTURAL EFFECTS INDUCED BY MUTAGENESIS AFFECTED BY CRYSTAL PACKING FACTORS: THE STRUCTURE OF A 30-51 DISULFIDE MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Proteins, 14, 1992
8RQF
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BU of 8rqf by Molmil
Cryo-EM structure of human NTCP-Bulevirtide complex
Descriptor: Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ...
Authors:Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P.
Deposit date:2024-01-18
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Cryo-EM structure of human NTCP-Bulevirtide complex
To Be Published
6RLX
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BU of 6rlx by Molmil
X-RAY STRUCTURE OF HUMAN RELAXIN AT 1.5 ANGSTROMS. COMPARISON TO INSULIN AND IMPLICATIONS FOR RECEPTOR BINDING DETERMINANTS
Descriptor: RELAXIN, A-CHAIN, B-CHAIN
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1991-06-21
Release date:1993-10-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.
J.Mol.Biol., 221, 1991
3HHR
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BU of 3hhr by Molmil
HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
Descriptor: HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
Authors:De Vos, A.M, Ultsch, M, Kossiakoff, A.A.
Deposit date:1993-12-30
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
7ZLH
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BU of 7zlh by Molmil
Cryo-EM structure of C-mannosyltransferase CeDPY19, in apo state, bound to CMT2-Fab and anti-Fab nanobody
Descriptor: Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ...
Authors:Bloch, J.S, Mukherjee, S, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P.
Deposit date:2022-04-15
Release date:2023-01-11
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
7ZLI
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BU of 7zli by Molmil
Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with Dol25-P-Man and bound to CMT2-Fab and anti-Fab nanobody
Descriptor: Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ...
Authors:Bloch, J.S, Mukherjee, S, Boilevin, J, Irobalieva, R, Darbre, T, Reymond, J.L, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P.
Deposit date:2022-04-15
Release date:2023-01-11
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
7ZLG
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BU of 7zlg by Molmil
Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with acceptor peptide and bound to CMT2-Fab and anti-Fab nanobody
Descriptor: Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ...
Authors:Bloch, J.S, Mukherjee, S, Mao, R, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P.
Deposit date:2022-04-15
Release date:2023-01-11
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
7ZLJ
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BU of 7zlj by Molmil
Cryo-EM structure of C-mannosyltransferase CeDPY19, in ternary complex with Dol25-P-C-Man and acceptor peptide, bound to CMT2-Fab and anti-Fab nanobody
Descriptor: Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ...
Authors:Bloch, J.S, Mao, R, Mukherjee, S, Boilevin, J, Irobalieva, R, Darbre, T, Reymond, J.L, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P.
Deposit date:2022-04-15
Release date:2023-01-11
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
7ZYI
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BU of 7zyi by Molmil
Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody
Descriptor: CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ...
Authors:Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2022-05-24
Release date:2022-07-13
Last modified:2022-08-10
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Cell Res., 32, 2022
1AAP
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BU of 1aap by Molmil
X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Descriptor: ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN
Authors:Hynes, T.R, Randal, M, Kennedy, L.A, Eigenbrot, C, Kossiakoff, A.A.
Deposit date:1990-09-14
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Biochemistry, 29, 1990
1CA0
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BU of 1ca0 by Molmil
BOVINE CHYMOTRYPSIN COMPLEXED TO APPI
Descriptor: BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Authors:Scheidig, A.J, Kossiakoff, A.A.
Deposit date:1997-01-23
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
8PG0
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BU of 8pg0 by Molmil
Human OATP1B3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ...
Authors:Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2023-06-17
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
8PHW
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BU of 8phw by Molmil
Human OATP1B1
Descriptor: CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ...
Authors:Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2023-06-20
Release date:2023-09-27
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
1Z7C
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BU of 1z7c by Molmil
Crystal Structure of Human Placental Lactogen
Descriptor: Chorionic somatomammotropin hormone
Authors:Walsh, S.T.R, Kossiakoff, A.A.
Deposit date:2005-03-24
Release date:2006-03-07
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure and Site 1 Binding Energetics of Human Placental Lactogen.
J.Mol.Biol., 358, 2006
8SLB
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BU of 8slb by Molmil
X-ray structure of CorA N-terminal domain in complex with conformation-specific synthetic antibody C12
Descriptor: CHLORIDE ION, Cobalt/magnesium transport protein CorA, sAB C12 Heavy Chain, ...
Authors:Dominik, P.K, Erramilli, S.K, Reddy, B.G, Kossiakoff, A.A.
Deposit date:2023-04-21
Release date:2023-06-07
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA.
J.Mol.Biol., 435, 2023
7PHQ
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BU of 7phq by Molmil
Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM
Descriptor: Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ...
Authors:Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P.
Deposit date:2021-08-18
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (8.45 Å)
Cite:Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
7PIJ
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BU of 7pij by Molmil
Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM
Descriptor: Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ...
Authors:Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P.
Deposit date:2021-08-20
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
7PHP
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BU of 7php by Molmil
Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM
Descriptor: Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ...
Authors:Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P.
Deposit date:2021-08-18
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
1HUW
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BU of 1huw by Molmil
THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
Descriptor: HUMAN GROWTH HORMONE
Authors:Ultsch, M.H, Somers, W.S, Kossiakoff, A.A, De Vos, A.M.
Deposit date:1993-09-22
Release date:1994-01-31
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
1KF9
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BU of 1kf9 by Molmil
PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Descriptor: EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238), PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE
Authors:Schiffer, C.A, Ultsch, M, Walsh, S, Somers, W, De Vos, A.M, Kossiakoff, A.A.
Deposit date:2001-11-19
Release date:2002-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
1BP3
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BU of 1bp3 by Molmil
THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Descriptor: PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION
Authors:Somers, W, Ultsch, M, De Vos, A.M, Kossiakoff, A.A.
Deposit date:1998-08-12
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
5UEA
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BU of 5uea by Molmil
Structure of antigen-Fab complex with Histone chaperone ASF1
Descriptor: Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1
Authors:Bailey, L.J, Kossiakoff, A.A.
Deposit date:2016-12-29
Release date:2018-01-10
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Antibody Switch Residue Engineering for Improved Crystallization Chaperones
To Be Published

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