Author results

1GH2
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF A NEW HUMAN THIOREDOXIN-LIKE PROTEIN
Descriptor:THIOREDOXIN-LIKE PROTEIN
Authors:Jin, J., Chen, X., Guo, Q., Yuan, J., Qiang, B., Rao, Z.
Deposit date:2000-11-01
Release date:2001-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structure of the catalytic domain of a human thioredoxin-like protein.
Eur.J.Biochem., 269, 2002
1J51
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CRYSTAL STRUCTURE OF CYTOCHROME P450CAM MUTANT (F87W/Y96F/V247L/C334A) WITH 1,3,5-TRICHLOROBENZENE
Descriptor:CYTOCHROME P450CAM, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Chen, X., Christopher, A., Jones, J., Guo, Q., Xu, F., Cao, R., Wong, L.L., Rao, Z.
Deposit date:2002-01-05
Release date:2002-01-23
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene
J.BIOL.CHEM., 277, 2002
1XFU
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) TRUNCATION MUTANT, EF-DELTA 64 IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFW
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 3'5' CYCLIC AMP (CAMP)
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFX
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN IN THE PRESENCE OF 10 MILLIMOLAR EXOGENOUSLY ADDED CALCIUM CHLORIDE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFY
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFZ
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN IN THE PRESENCE OF 1 MILLIMOLAR EXOGENOUSLY ADDED CALCIUM CHLORIDE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XUO
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X-RAY STRUCTURE OF LFA-1 I-DOMAIN BOUND TO A 1,4-DIAZEPANE-2,5-DIONE INHIBITOR AT 1.8A RESOLUTION
Descriptor:Integrin alpha-L, MAGNESIUM ION, (2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHYL)-1,4-DIAZEPAN-1-YL]-N-METHYL-3-(2-NAPHTHYL)PROPANAMIDE
Authors:Wattanasin, S., Kallen, J., Myers, S., Guo, Q., Sabio, M., Ehrhardt, C., Albert, R., Hommel, U., Weckbecker, G., Welzenbach, K.
Deposit date:2004-10-26
Release date:2005-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1
Bioorg.Med.Chem.Lett., 15, 2005
1Y0V
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND PYROPHOSPHATE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.-J.
Deposit date:2004-11-16
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
Embo J., 24, 2005
2PQ3
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N-TERMINAL CALMODULIN ZN-TRAPPED INTERMEDIATE
Descriptor:Calmodulin, CACODYLATE ION, ZINC ION
Authors:Warren, J.T., Guo, Q., Tang, W.J.
Deposit date:2007-05-01
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step.
J.Mol.Biol., 374, 2007
2WBY
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:INSULIN-DEGRADING ENZYME, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WC0
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH IODINATED INSULIN
Descriptor:INSULIN-DEGRADING ENZYME, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
3BM4
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CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSE PYROPHOSPHATASE NUDT5 IN COMPLEX WITH MAGNESIUM AND AMPCPR
Descriptor:ADP-sugar pyrophosphatase, MAGNESIUM ION, ALPHA-BETA METHYLENE ADP-RIBOSE
Authors:Zha, M., Guo, Q., Zhang, Y., Zhong, C., Ou, Y., Ding, J.
Deposit date:2007-12-12
Release date:2008-05-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Mechanism of ADP-Ribose Hydrolysis By Human NUDT5 From Structural and Kinetic Studies
J.Mol.Biol., 379, 2008
3H44
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME IN COMPLEX WITH MACROPHAGE INFLAMMATORY PROTEIN 1 ALPHA
Descriptor:Insulin-degrading enzyme, C-C motif chemokine 3, 1,4-DIETHYLENE DIOXIDE, ...
Authors:Ren, M., Guo, Q., Tang, W.J.
Deposit date:2009-04-17
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Macrophage Inflammatory Protein-1 Is A Novel High Affinity Substrate For Human Insulin Degrading Enzyme
To be Published
3J3V
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ATOMIC MODEL OF THE IMMATURE 50S SUBUNIT FROM BACILLUS SUBTILIS (STATE I-A)
Descriptor:50S ribosomal protein L32, 50S ribosomal protein L34, 50S ribosomal protein L1, ...
Authors:Li, N., Guo, Q., Zhang, Y., Yuan, Y., Ma, C., Lei, J., Gao, N.
Deposit date:2013-04-28
Release date:2013-06-12
Last modified:2013-08-28
Method:ELECTRON MICROSCOPY (13.3 Å)
Cite:Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
3J3W
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ATOMIC MODEL OF THE IMMATURE 50S SUBUNIT FROM BACILLUS SUBTILIS (STATE II-A)
Descriptor:ribosome RNA 23S, 50S ribosomal protein L32, 50S ribosomal protein L2, ...
Authors:Li, N., Guo, Q., Zhang, Y., Yuan, Y., Ma, C., Lei, J., Gao, N.
Deposit date:2013-04-28
Release date:2013-06-12
Last modified:2013-08-28
Method:ELECTRON MICROSCOPY (10.7 Å)
Cite:Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
3N56
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME (IDE) IN COMPLEX WITH HUMAN B-TYPE NATRIURETIC PEPTIDE (BNP)
Descriptor:Insulin-degrading enzyme, Natriuretic peptides B, ZINC ION, ...
Authors:Funke, T., Guo, Q., Tang, W.-J.
Deposit date:2010-05-24
Release date:2010-11-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)
To be Published
3N57
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME (IDE) IN COMPLEX WITH HUMAN ATRIAL NATRIURETIC PEPTIDE (ANP)
Descriptor:Insulin-degrading enzyme, Atrial natriuretic factor, ZINC ION
Authors:Funke, T., Guo, Q., Tang, W.-J.
Deposit date:2010-05-24
Release date:2010-11-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)
To be Published
4CSU
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CRYO-EM STRUCTURES OF THE 50S RIBOSOME SUBUNIT BOUND WITH OBGE
Descriptor:50S RIBOSOMAL PROTEIN L28, 50S RIBOSOMAL PROTEIN L29, 50S RIBOSOMAL PROTEIN L30, ...
Authors:Feng, B., Mandava, C.S., Guo, Q., Wang, J., Cao, W., Li, N., Zhang, Y., Zhang, Y., Wang, Z., Wu, J., Sanyal, S., Lei, J., Gao, N.
Deposit date:2014-03-10
Release date:2014-06-04
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase.
Plos Biol., 12, 2014
5XXB
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LARGE SUBUNIT OF TOXOPLASMA GONDII RIBOSOME
Descriptor:25S RNA, 5S RNA, 5.8S RNA, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-03
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XXU
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SMALL SUBUNIT OF TOXOPLASMA GONDII RIBOSOME
Descriptor:18S RNA, Ribosomal protein uS2, Ribosomal protein eS1, ...
Authors:LI, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-05
Release date:2017-08-30
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XY3
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LARGE SUBUNIT OF TRICHOMONAS VAGINALIS RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-06
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XYI
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SMALL SUBUNIT OF TRICHOMONAS VAGINALIS RIBOSOME
Descriptor:18S, 40S ribosomal protein SA, Ribosomal protein S3Ae, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-08
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
3TN2
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STRUCTURE ANALYSIS OF MIP1-BETA P8A
Descriptor:C-C motif chemokine 4, ZINC ION
Authors:Guo, Q., Tang, W.J.
Deposit date:2011-09-01
Release date:2012-09-05
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4GSF
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THE STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH (S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO]-ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER
Descriptor:Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015