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3FJ9
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CRYSTAL STRUCTURE OF F85W MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
J.Mol.Biol., 393, 2009
3FJA
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CRYSTAL STRUCTURE OF F132W MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
J.Mol.Biol., 393, 2009
3FJB
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CRYSTAL STRUCTURE OF V31I MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
J.Mol.Biol., 393, 2009
3FJC
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CRYSTAL STRUCTURE OF L44W MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
J.Mol.Biol., 393, 2009
3FJD
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CRYSTAL STRUCTURE OF L44F/F132W MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
J.Mol.Biol., 393, 2009
3FJE
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CRYSTAL STRUCTURE OF C83S MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3FJF
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CRYSTAL STRUCTURE OF C83T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3FJH
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CRYSTAL STRUCTURE OF C83A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3FJI
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CRYSTAL STRUCTURE OF K12V/C83I/C117V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3FJJ
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CRYSTAL STRUCTURE OF C83V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3FJK
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CRYSTAL STRUCTURE OF A66C MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2008-12-14
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3HOM
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CRYSTAL STRUCTURE OF OXIDIZED A66C MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Acidic fibroblast growth factor, FORMIC ACID, SULFATE ION
Authors:Blaber, M., Lee, J.
Deposit date:2009-06-02
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3Q7W
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CRYSTAL STRUCTURE OF SYMFOIL-4P/PV1: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE, PRIMITIVE VERSION 1
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure, SULFATE ION
Authors:Blaber, M., Lee, J.
Deposit date:2011-01-05
Release date:2012-01-11
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Proc.Natl.Acad.Sci.USA, 110, 2013
3Q7X
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CRYSTAL STRUCTURE OF SYMFOIL-4P/PV1: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE, PRIMITIVE VERSION 1
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure, SULFATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Blaber, M., Lee, J.
Deposit date:2011-01-05
Release date:2012-01-11
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Proc.Natl.Acad.Sci.USA, 110, 2013
3Q7Y
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CRYSTAL STRUCTURE OF K15R/E18D/Y22W/H41G/F44W/E51D/E53P/K57R/E60D/Y64W/H82G/F85W/E90D/E94P/K98R/E101D/Y108W/H129G/F132W/E137D SYMFOIL-4P: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE
Descriptor:De novo designed beta-trefoil architecture with symmetric primary structure
Authors:Blaber, M., Lee, J.
Deposit date:2011-01-05
Release date:2012-01-11
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Proc.Natl.Acad.Sci.USA, 110, 2013
3SNV
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CRYSTAL STRUCTURE OF SYMFOIL-4T PERMUTATION #1: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE
Descriptor:Symfoil-4T/Permutation #1 synthetic protein, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION
Authors:Blaber, M., Longo, L., Lee, J.
Deposit date:2011-06-29
Release date:2012-07-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Folding pathway redundancy in symmetric protein architecture
To be Published
4D8H
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CRYSTAL STRUCTURE OF SYMFOIL-4P/PV2: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE, PRIMITIVE VERSION 2 (6XLEU / PV1)
Descriptor:de novo protein, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION
Authors:Blaber, M., Longo, L.
Deposit date:2012-01-10
Release date:2013-01-16
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Proc.Natl.Acad.Sci.USA, 110, 2013
4OW4
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BETA-TREFOIL DESIGNED BY FOLDING NUCLEUS SYMMETRIC EXPANSION ("PHIFOIL")
Descriptor:Beta-terfoil designed by folding nucleus symmetric expansion ("Phifoil"), SULFATE ION
Authors:Blaber, M., Longo, L.M.
Deposit date:2014-01-31
Release date:2014-12-17
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Evolution and design of protein structure by folding nucleus symmetric expansion.
Structure, 22, 2014
4Q9G
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CRYSTAL STRUCTURE OF K12V/C16S/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9P
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CRYSTAL STRUCTURE OF C16T/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QAL
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CRYSTAL STRUCTURE OF C117A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-05
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBC
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM FORMATE BUFFER
Descriptor:Fibroblast growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-07
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM CITRATE BUFFER
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-08
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QC4
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CRYSTAL STRUCTURE OF C117S MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, SODIUM ION, ...
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-09
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
1JQZ
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HUMAN ACIDIC FIBROBLAST GROWTH FACTOR. 141 AMINO ACID FORM WITH AMINO TERMINAL HIS TAG.
Descriptor:acidic fibroblast growth factor, FORMIC ACID
Authors:Brych, S.R., Blaber, S.I., Logan, T.M., Blaber, M.
Deposit date:2001-08-09
Release date:2001-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil.
Protein Sci., 10, 2001