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1GPM
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BU of 1gpm by Molmil
ESCHERICHIA COLI GMP SYNTHETASE COMPLEXED WITH AMP AND PYROPHOSPHATE
Descriptor: ADENOSINE MONOPHOSPHATE, CITRIC ACID, GMP SYNTHETASE, ...
Authors:Tesmer, J.J.G.
Deposit date:1995-04-04
Release date:1996-01-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Nat.Struct.Biol., 3, 1996
2BCJ
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BU of 2bcj by Molmil
Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
Descriptor: G-protein-coupled receptor kinase 2, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tesmer, J.J.G.
Deposit date:2005-10-19
Release date:2005-12-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.061 Å)
Cite:Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex
Science, 310, 2005
1CS4
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BU of 1cs4 by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
Descriptor: 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R.
Deposit date:1999-08-16
Release date:2001-01-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
6PCV
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BU of 6pcv by Molmil
Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1
Authors:Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G.
Deposit date:2019-06-18
Release date:2019-10-23
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
1OMW
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BU of 1omw by Molmil
Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits
Descriptor: G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1
Authors:Lodowski, D.T, Pitcher, J.A, Capel, W.D, Lefkowitz, R.J, Tesmer, J.J.G.
Deposit date:2003-02-26
Release date:2003-06-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Keeping G proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G-Beta-Gamma
Science, 300, 2003
6U7C
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BU of 6u7c by Molmil
Human GRK2 in complex with Gbetagamma subunits and CCG258747
Descriptor: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Bouley, R, Tesmer, J.J.G.
Deposit date:2019-09-02
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor.
Mol.Pharmacol., 97, 2020
1YM7
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BU of 1ym7 by Molmil
G Protein-Coupled Receptor Kinase 2 (GRK2)
Descriptor: Beta-adrenergic receptor kinase 1
Authors:Lodowski, D.T, Barnhill, J.F, Pyskadlo, R.M, Ghirlando, R, Sterne-Marr, R, Tesmer, J.J.G.
Deposit date:2005-01-20
Release date:2005-07-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:The role of Gbetagamma and domain interfaces in the activation of G protein-coupled receptor kinase 2
Biochemistry, 44, 2005
8UAP
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BU of 8uap by Molmil
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441
Descriptor: (3Z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1H-pyrrol-2-yl]methylidene}-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5
Authors:Chen, Y, Tesmer, J.J.G.
Deposit date:2023-09-21
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.
Eur.J.Med.Chem., 264, 2023
8UAQ
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BU of 8uaq by Molmil
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL018-21
Descriptor: (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5
Authors:Chen, Y, Tesmer, J.J.G.
Deposit date:2023-09-21
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.
Eur.J.Med.Chem., 264, 2023
6MTW
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BU of 6mtw by Molmil
Lysosomal Phospholipase A2 in complex with Zinc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Group XV phospholipase A2, ...
Authors:Bouley, R, Tesmer, J.J.G.
Deposit date:2018-10-22
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural Basis of Lysosomal Phospholipase A2Inhibition by Zn2.
Biochemistry, 58, 2019
6O5G
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BU of 6o5g by Molmil
Calmodulin in complex with isomalbrancheamide D
Descriptor: (5aS,12aS,13aS)-9-bromo-8-chloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7 ,6-b]carbazol-14-one, CALCIUM ION, Calmodulin-1, ...
Authors:Beyett, T.S, Fraley, A.E, Tesmer, J.J.G.
Deposit date:2019-03-02
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.
Proc.Natl.Acad.Sci.USA, 116, 2019
7MTB
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BU of 7mtb by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6
Descriptor: Fab6 heavy chain, Fab6 light chain, RETINAL, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
7MT8
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BU of 7mt8 by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin
Descriptor: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
7MTA
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BU of 7mta by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1
Descriptor: Fab1 Heavy chain, Fab1 Light chain, RETINAL, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
7MT9
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BU of 7mt9 by Molmil
Rhodopsin kinase (GRK1) in complex with rhodopsin
Descriptor: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
5TXF
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BU of 5txf by Molmil
Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Phosphatidylcholine-sterol acyltransferase, ...
Authors:Manthei, K.A, Glukhova, A, Tesmer, J.J.G.
Deposit date:2016-11-16
Release date:2017-10-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.
J. Biol. Chem., 292, 2017
5W5V
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BU of 5w5v by Molmil
TBK1 co-crystal structure with amlexanox
Descriptor: 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2017-06-15
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.645 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
6BOD
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BU of 6bod by Molmil
TBK1 in complex with ethyl ester analog of amlexanox
Descriptor: Serine/threonine-protein kinase TBK1, ethyl 2-amino-5-oxo-7-(propan-2-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2017-11-19
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
6CQ5
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BU of 6cq5 by Molmil
TBK1 in Complex with Sulfone Analog of Amlexanox
Descriptor: 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.354 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6CQ4
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BU of 6cq4 by Molmil
TBK1 in Complex with Cyclohexyl Analog of Amlexanox
Descriptor: 2-amino-7-(4,4-difluorocyclohexyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6CQ0
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BU of 6cq0 by Molmil
TBK1 in Complex with Dimethyl Amino Analog of Amlexanox
Descriptor: 2-amino-7-[3-(dimethylamino)propyl]-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1
Authors:Beyett, T.S, Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6EEB
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BU of 6eeb by Molmil
Calmodulin in complex with malbrancheamide
Descriptor: (5aS,12aS,13aS)-8,9-dichloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, CALCIUM ION, Calmodulin-1, ...
Authors:Beyett, T.S, Fraley, A.E, Tesmer, J.J.G.
Deposit date:2018-08-13
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.
Proc.Natl.Acad.Sci.USA, 116, 2019
7SK9
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BU of 7sk9 by Molmil
Cryo-EM structure of human ACKR3 in complex with a small molecule partial agonist CCX662, and an intracellular Fab
Descriptor: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK3
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BU of 7sk3 by Molmil
Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab
Descriptor: Atypical chemokine receptor 3, CHOLESTEROL, CID24 Fab heavy chain, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK7
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BU of 7sk7 by Molmil
Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, and an extracellular Fab
Descriptor: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Anti-Fab nanobody, Atypical chemokine receptor 3, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022

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