Author results

6CSH
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CRYOEM STRUCTURE OF HUMAN ENTEROVIRUS D68 EMPTIED PARTICLE (PH 5.5 AND 33 DEGREES CELSIUS)
分子名称:viral protein 1, viral protein 3, viral protein 2
著者Liu, Y., Rossmann, M.G.
登録日2018-03-20
公開日2018-12-19
最終更新日2019-01-09
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular basis for the acid-initiated uncoating of human enterovirus D68.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CT7
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FAB OF ANTI-A-SYNUCLEIN ANTIBODY BIIB054 IN COMPLEX WITH ACETYLATED A-SYNUCLEIN PEPTIDE (1-10)
分子名称:BIIB054 Fab light chain, BIIB054 Fab heavy chain, ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS, ...
著者Arndt, J.W.
登録日2018-03-22
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiol. Dis., 124, 2018
6MZI
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CRYOEM STRUCTURE OF HUMAN ENTEROVIRUS D68 EXPANDED 1 PARTICLE (PH 6.5, 4 DEGREES CELSIUS, 3 MIN)
分子名称:viral protein 1, viral protein 3, viral protein 2, ...
著者Liu, Y., Rossmann, M.G.
登録日2018-11-05
公開日2018-12-19
最終更新日2019-01-09
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Molecular basis for the acid-initiated uncoating of human enterovirus D68.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YYS
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CRYO-EM STRUCTURE OF L-FUCOKINASE, GDP-FUCOSE PYROPHOSPHORYLASE (FKP)IN BACTEROIDES FRAGILIS
分子名称:L-fucokinase, L-fucose-1-P guanylyltransferase
著者Wang, J., Hu, H., Liu, Y., Zhou, Q., Wu, P., Yan, N., Wang, H.W., Wu, J.W., Sun, L.
登録日2017-12-11
公開日2018-12-12
最終更新日2019-05-01
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis.
Protein Cell, 10, 2019
5YTS
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CRYSTAL STRUCTURE OF YB1 COLD-SHOCK DOMAIN IN COMPLEX WITH UCUUCU
分子名称:Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*CP*UP*UP*C)-3'), SULFATE ION
著者Yang, X., Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2019-06-19
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 2019
5YTT
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CRYSTAL STRUCTURE OF YB1 COLD-SHOCK DOMAIN IN COMPLEX WITH UCAUGU
分子名称:Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*GP*U)-3'), SULFATE ION
著者Yang, X., Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2019-06-19
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 2019
5YTV
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CRYSTAL STRUCTURE OF YB1 COLD-SHOCK DOMAIN IN COMPLEX WITH UCAUCU
分子名称:Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*CP*U)-3')
著者Yang, X., Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2019-06-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 2019
5YTX
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CRYSTAL STRUCTURE OF YB1 COLD-SHOCK DOMAIN IN COMPLEX WITH UCAACU
分子名称:Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*AP*CP*U)-3')
著者Yang, X., Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2019-06-19
実験手法X-RAY DIFFRACTION (1.551 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 2019
6MZC
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HUMAN TFIID BC CORE
分子名称:Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 4, Transcription initiation factor TFIID subunit 5, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZD
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HUMAN TFIID LOBE A CANONICAL
分子名称:Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 3, Transcription initiation factor TFIID subunit 4, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (9.8 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZL
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HUMAN TFIID CANONICAL STATE
分子名称:Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 3, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (23 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZM
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HUMAN TFIID BOUND TO PROMOTER DNA AND TFIIA
分子名称:Transcription initiation factor TFIID subunit 1, TAF1, Transcription initiation factor TFIID subunit 2, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (7.5 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6BJF
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NMR STRUCTURAL AND BIOPHYSICAL FUNCTIONAL ANALYSIS OF INTRACELLULAR LOOP 5 OF THE NHE1 ISOFORM OF THE NA+/H+ EXCHANGER.
分子名称:GLY-LEU-THR-TRP-PHE-ILE-ASN-LYS-PHE-ARG-ILE-VAL-LYS
著者McKay, R., Wong, K., Towle, K., Fliegel, L.
登録日2017-11-06
公開日2018-11-14
最終更新日2019-06-05
実験手法SOLUTION NMR
主引用文献Diverse residues of intracellular loop 5 of the Na+/H+exchanger modulate proton sensing, expression, activity and targeting.
Biochim Biophys Acta Biomembr, 1861, 2019
5Z07
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CRYSTAL STRUCTURE OF CENTROMERE PROTEIN CENP-I
分子名称:Cenp-I
著者Tian, W., Hu, L.Q., He, X.
登録日2017-12-18
公開日2018-10-31
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment.
Nucleic Acids Res., 47, 2019
5Z08
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THE CRYSTAL STRUCTURE OF KINETOCHORE SUBUNITS CENP-H/I/K TRIPLE COMPLEX
分子名称:Cenp-I, Cenp-K, Cenp-H
著者Tian, W., Hu, L.Q., He, X.
登録日2017-12-18
公開日2018-10-31
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment.
Nucleic Acids Res., 47, 2019
6BAX
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR 6-(3-AMINOPHENYL)-3-((2-CHLOROPHENYL)THIO)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BAZ
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (S)-5-((2-CHLOROPHENYL)THIO)-6'-((4-FLUOROPHENYL)AMINO)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BB0
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-3-((2-CHLOROPHENYL)THIO)-6-(3-((4-FLUOROPHENYL)AMINO)PHENYL)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BB1
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-5-((2-CHLOROPHENYL)THIO)-6'-(4-FLUOROPHENOXY)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BB2
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (S)-5-((2-CHLOROPHENYL)THIO)-6'-(4-FLUOROPHENOXY)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BB3
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR 3-((2-CHLOROPHENYL)THIO)-6-(6-((4-FLUOROPHENYL)AMINO)PYRIDIN-2-YL)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ...
著者Chen, Z., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6MLC
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PHD6 DOMAIN OF MLL3 IN COMPLEX WITH HISTONE H4
分子名称:Histone-lysine N-methyltransferase 2C, Histone H4, ZINC ION, ...
著者Dong, A., Liu, Y., Qin, S., Lei, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-09-27
公開日2018-10-24
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
6BAD
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-3-((2-CHLOROPHENYL)THIO)-6-(3-((4-FLUOROPHENYL)AMINO)PHENYL)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-12
公開日2018-10-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BAG
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-5-((2-CHLOROPHENYL)THIO)-6'-((4-FLUOROPHENYL)AMINO)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-12
公開日2018-10-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6A3V
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COMPLEX STRUCTURE OF HUMAN 4-1BB AND 4-1BBL
分子名称:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE
著者Li, Y., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
登録日2018-06-17
公開日2018-10-10
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (3.391 Å)
主引用文献Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018