Author results

3U86
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CRYSTAL STRUCTURE OF HUMAN MENIN IN COMPLEX WITH JUND
Descriptor:Menin, Transcription factor jun-D
Authors:Huang, J., Wan, B., Lei, M.
Deposit date:2011-10-15
Release date:2012-02-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.843 Å)
Cite:The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3U88
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CRYSTAL STRUCTURE OF HUMAN MENIN IN COMPLEX WITH MLL1 AND LEDGF
Descriptor:Menin, Histone-lysine N-methyltransferase 2A, Lens epithelium-derived growth factor, ...
Authors:Huang, J., Wan, B., Lei, M.
Deposit date:2011-10-16
Release date:2012-02-15
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
4DNC
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CRYSTAL STRUCTURE OF HUMAN MOF IN COMPLEX WITH MSL1
Descriptor:Histone acetyltransferase KAT8, Male-specific lethal 1 homolog, ZINC ION
Authors:Huang, J., Lei, M.
Deposit date:2012-02-08
Release date:2012-07-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex.
Cell Res., 22, 2012
4GM3
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-101
Descriptor:WD repeat-containing protein 5, MM-101
Authors:Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Method:X-RAY DIFFRACTION (3.393 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GM8
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-102
Descriptor:WD repeat-containing protein 5, MM-102
Authors:Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GM9
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-401
Descriptor:WD repeat-containing protein 5, MM-401
Authors:Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Liu, L., Dou, Y., Lei, M., Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
4GMB
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-402
Descriptor:WD repeat-containing protein 5, MM-402
Authors:Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 2017
4I80
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CRYSTAL STRUCTURE OF HUMAN MENIN IN COMPLEX WITH A HIGH-AFFINITY MACROCYCLIC PEPTIDOMIMETICS
Descriptor:Menin, macrocyclic peptidomimetic
Authors:Huang, J., Lei, M.
Deposit date:2012-12-01
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction.
J.Med.Chem., 56, 2013
4M7C
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CRYSTAL STRUCTURE OF THE TRF2-BINDING MOTIF OF SLX4 IN COMPLEX WITH THE TRFH DOMAIN OF TRF2
Descriptor:Telomeric repeat-binding factor 2, Peptide from Structure-specific endonuclease subunit SLX4
Authors:Wan, B., Chen, Y., Wu, J., Liu, Y., Lei, M.
Deposit date:2013-08-12
Release date:2013-09-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Cell Rep, 4, 2013
4O26
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CRYSTAL STRUCTURE OF THE TRBD DOMAIN OF TERT AND THE CR4/5 OF TR
Descriptor:Telomerase reverse transcriptase, Telomerase TR, SULFATE ION
Authors:Huang, J., Wu, J., Lei, M.
Deposit date:2013-12-16
Release date:2014-05-07
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:Structural basis for protein-RNA recognition in telomerase.
Nat.Struct.Mol.Biol., 21, 2014
4ZMI
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CRYSTAL STRUCTURE OF THE HELICAL DOMAIN OF S. POMBE TAZ1
Descriptor:Telomere length regulator taz1, MAGNESIUM ION, COBALT (II) ION
Authors:Deng, W., Wu, J., Wang, F., Lei, M.
Deposit date:2015-05-04
Release date:2015-09-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2.
Cell Res., 25, 2015
4ZMK
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CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OF S. POMBE TAZ1
Descriptor:Telomere length regulator taz1
Authors:Deng, W., Wu, J., Wang, F., Lei, M.
Deposit date:2015-05-04
Release date:2015-09-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2.
Cell Res., 25, 2015
4ZOU
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF SLX4
Descriptor:Structure-specific endonuclease subunit SLX4
Authors:Wan, B., Chen, Y., Wu, J., Liu, Y., Lei, M.
Deposit date:2015-05-07
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The BTB domain is both a structural and functional pivot of the SLX4-nuclease complex
to be published
5DOF
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CRYSTAL STRUCTURE OF TETRAHYMENA P19
Descriptor:Telomerase-associated protein 19
Authors:Wan, B., Tang, T., Wu, J., Lei, M.
Deposit date:2015-09-11
Release date:2015-11-25
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.
Nat.Struct.Mol.Biol., 22, 2015
5DOI
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CRYSTAL STRUCTURE OF TETRAHYMENA P45N AND P19
Descriptor:Telomerase-associated protein 19, Telomerase associated protein p45
Authors:Wan, B., Tang, T., Wu, J., Lei, M.
Deposit date:2015-09-11
Release date:2015-11-25
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
5DOK
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CRYSTAL STRUCTURE OF TETRAHYMENA P45C
Descriptor:Telomerase associated protein p45, MAGNESIUM ION
Authors:Wan, B., Tang, T., Wu, J., Lei, M.
Deposit date:2015-09-11
Release date:2015-11-25
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
5F59
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THE CRYSTAL STRUCTURE OF MLL3 SET DOMAIN
Descriptor:Histone-lysine N-methyltransferase 2C, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F5E
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THE CRYSTAL STRUCTURE OF MLL1 SET DOMAIN WITH N3816I/Q3867L MUTATION
Descriptor:Histone-lysine N-methyltransferase 2A, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6K
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CRYSTAL STRUCTURE OF THE MLL3-ASH2L-RBBP5 COMPLEX
Descriptor:Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6L
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THE CRYSTAL STRUCTURE OF MLL1 (N3861I/Q3867L) IN COMPLEX WITH RBBP5 AND ASH2L
Descriptor:Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5WQD
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CRYSTAL STRUCTURE OF TRF2 TRFH IN COMPLEX WITH AN NBS1 PEPTIDE
Descriptor:Telomeric repeat-binding factor 2, Nibrin
Authors:Hu, C., Chen, Y., Lei, M.
Deposit date:2016-11-26
Release date:2017-03-08
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
Mol. Cell, 65, 2017
5XUP
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CRYSTAL STRUCTURE OF TRF1 AND TERB1
Descriptor:Telomeric repeat-binding factor 1, Telomere repeats-binding bouquet formation protein 1
Authors:Long, J., Huang, C., Wu, J., Lei, M.
Deposit date:2017-06-24
Release date:2017-11-01
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Telomeric TERB1-TRF1 interaction is crucial for male meiosis.
Nat. Struct. Mol. Biol., 24, 2017
5Y58
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CRYSTAL STRUCTURE OF KU70/80 AND TLC1
Descriptor:ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, TLC1
Authors:Chen, H., Xue, J., Wu, J., Lei, M.
Deposit date:2017-08-08
Release date:2017-12-20
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
5Y59
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CRYSTAL STRUCTURE OF KU80 AND SIR4
Descriptor:ATP-dependent DNA helicase II subunit 2, Sir4p, SULFATE ION
Authors:Chen, H., Xue, J., Wu, J., Lei, M.
Deposit date:2017-08-08
Release date:2017-12-20
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
5Y5A
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CRYSTAL STRUCTURE OF EST1 AND CDC13
Descriptor:KLLA0F20702p, KLLA0F20922p
Authors:Chen, H., Xue, J., Wu, J., Lei, M.
Deposit date:2017-08-08
Release date:2017-12-20
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018