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5XXB
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LARGE SUBUNIT OF TOXOPLASMA GONDII RIBOSOME
Descriptor:25S RNA, 5S RNA, 5.8S RNA, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-03
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XXU
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SMALL SUBUNIT OF TOXOPLASMA GONDII RIBOSOME
Descriptor:18S RNA, Ribosomal protein uS2, Ribosomal protein eS1, ...
Authors:LI, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-05
Release date:2017-08-30
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XY3
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LARGE SUBUNIT OF TRICHOMONAS VAGINALIS RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-06
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XYI
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SMALL SUBUNIT OF TRICHOMONAS VAGINALIS RIBOSOME
Descriptor:18S, 40S ribosomal protein SA, Ribosomal protein S3Ae, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-08
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XYM
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LARGE SUBUNIT OF MYCOBACTERIUM SMEGMATIS
Descriptor:50S ribosomal protein L32, 50S ribosomal protein L33 2, 50S ribosomal protein L34, ...
Authors:Li, Z., Ge, X., Zhang, Y., Zheng, L., Sanyal, S., Gao, N.
Deposit date:2017-07-09
Release date:2017-09-27
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers.
Protein Cell, 9, 2018
5XYU
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SMALL SUBUNIT OF MYCOBACTERIUM SMEGMATIS RIBOSOME
Descriptor:16S RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Li, Z., Zhang, Y., Zheng, L., Ge, X., Sanyal, S., Gao, N.
Deposit date:2017-07-10
Release date:2017-09-27
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers.
Protein Cell, 9, 2018
4OKG
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LPXC FROM P.AERUGINOSA WITH THE INHIBITOR 6-(BENZIMIDAZOL-1-YL)-5-[4-[2-[6-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-PYRIDYL]ETHYNYL]PHENYL]PYRIDINE-3-CARBOHYDROXAMIC ACID
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-({6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethynyl)phenyl]pyridine-3-carboxamide
Authors:Olivier, N.B., Lahiri, S.D., Prince, D.B.
Deposit date:2014-01-22
Release date:2014-09-24
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Overexpression of Pseudomonas aeruginosa LpxC in the Presence of an Inhibitor in an acrB Deletion Escherichia coli strain for Structural Studies
Protein Express.Purif., 2014
5XLO
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ANTI-CRISPR PROTEINS ACRF1/2 BOUND TO CSY SURVEILLANCE COMPLEX WITH A 32NT SPACER CRRNA BACKBONE REGION
Descriptor:CRISPR-associated protein Csy3, crRNA with 32nt spacer sequence, Uncharacterized protein AcrF1
Authors:Peng, R., Shi, Y., Gao, G.F.
Deposit date:2017-05-11
Release date:2018-01-10
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.
Cell Res., 27, 2017
5XLP
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ANTI-CRISPR PROTEINS ACRF1/2 BOUND TO CSY SURVEILLANCE COMPLEX WITH A 20NT SPACER CRRNA BACKBONE REGION
Descriptor:CRISPR-associated protein Csy3, crRNA with 20nt spacer sequence, Uncharacterized protein AcrF1
Authors:Peng, R., Shi, Y., Gao, G.F.
Deposit date:2017-05-11
Release date:2018-01-10
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.
Cell Res., 27, 2017
4HQM
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THE CRYSTAL STRUCTURE OF QSRR-MENADIONE COMPLEX
Descriptor:QsrR protein, 2-methylnaphthalene-1,4-diol
Authors:Ji, Q., Zhang, L., Jones, M.B., Sun, F., Deng, X., Liang, H., Brugarolas, P., Gao, N., Peterson, S.N., Lan, L., Bae, T., He, C.
Deposit date:2012-10-25
Release date:2013-03-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Proc.Natl.Acad.Sci.USA, 110, 2013
6B3E
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CRYSTAL STRUCTURE OF HUMAN CDK12/CYCLINK IN COMPLEX WITH AN INHIBITOR
Descriptor:Cyclin-dependent kinase 12, Cyclin-K, MAGNESIUM ION, ...
Authors:Ferguson, A.D.
Deposit date:2017-09-21
Release date:2017-12-27
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Structure-Based Design of Selective Noncovalent CDK12 Inhibitors.
ChemMedChem, 13, 2018
3U2D
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S. AUREUS GYRB ATPASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:DNA gyrase subunit B, 4-bromo-5-methyl-N-[1-(3-nitropyridin-2-yl)piperidin-4-yl]-1H-pyrrole-2-carboxamide, MAGNESIUM ION
Authors:Boriack-Sjodin, P.A., Prince, D.B., Eakin, A.E., Sherer, B.A.
Deposit date:2011-10-03
Release date:2012-01-11
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
Antimicrob.Agents Chemother., 56, 2012
3U2K
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S. AUREUS GYRB ATPASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:DNA gyrase subunit B, 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)pyridine-4-carboxamide, MAGNESIUM ION
Authors:Boriack-Sjodin, P.A., Prince, D.B., Eakin, A.E., Sherer, B.A.
Deposit date:2011-10-03
Release date:2012-01-11
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
Antimicrob.Agents Chemother., 56, 2012
4DDP
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CRYSTAL STRUCTURE OF BECLIN 1 EVOLUTIONARILY CONSERVED DOMAIN(ECD)
Descriptor:Beclin-1
Authors:Huang, W.J., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2012-01-19
Release date:2012-02-22
Method:X-RAY DIFFRACTION (1.547 Å)
Cite:Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
Cell Res., 2012
4MCB
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H.INFLUENZAE TRMD IN COMPLEX WITH N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, GLYCEROL, SULFATE ION, ...
Authors:Olivier, N.B., Hill, P.
Deposit date:2013-08-21
Release date:2013-09-04
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
J.Med.Chem., 56, 2013
4MCC
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HINTRMD IN COMPLEX WITH N-[4-(AMINOMETHYL)BENZYL]-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-[4-(aminomethyl)benzyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Olivier, N.B., Hill, P.
Deposit date:2013-08-21
Release date:2013-09-04
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
J.Med.Chem., 56, 2013
4MCD
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HINTRMD IN COMPLEX WITH 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one
Authors:Lahiri, S.
Deposit date:2013-08-21
Release date:2013-09-25
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
J.Med.Chem., 56, 2013
4RAX
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A REGULATORY DOMAIN OF AN ION CHANNEL
Descriptor:Piezo-type mechanosensitive ion channel component 1
Authors:Ge, J., Yang, M.
Deposit date:2014-09-11
Release date:2015-09-23
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Architecture of the mammalian mechanosensitive Piezo1 channel.
Nature, 527, 2015
4U3B
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LPXC FROM A.AAEOLICUS IN COMPLEX WITH THE MMP INHIBITOR 4-[[4-(4-CHLOROPHENOXY)PHENYL]SULFANYLMETHYL]TETRAHYDROPYRAN-4-CARBOHYDROXAMIC ACID - COMPOUND 2
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, IMIDAZOLE, ZINC ION, ...
Authors:Olivier, N.B.
Deposit date:2014-07-19
Release date:2014-10-01
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.
Acs Med.Chem.Lett., 5, 2014
4U3D
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LPXC FROM A.AAEOLICUS IN COMPLEX WITH 4-[[4-[2-[4-(MORPHOLINOMETHYL)PHENYL]ETHYNYL]PHENOXY]METHYL]TETRAHYDROPYRAN-4-CARBOHYDROXAMIC ACID (COMPOUND 9)
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, IMIDAZOLE, ZINC ION, ...
Authors:Olivier, N.B.
Deposit date:2014-07-19
Release date:2014-10-01
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.
Acs Med.Chem.Lett., 5, 2014
5ID6
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STRUCTURE OF CPF1/RNA COMPLEX
Descriptor:Cpf1, RNA (5'-R(P*AP*AP*UP*UP*UP*CP*UP*AP*CP*UP*AP*AP*GP*UP*GP*UP*AP*GP*AP*UP*C)-3'), MAGNESIUM ION
Authors:Dong, D., Ren, K., Qiu, X., Wang, J., Huang, Z.
Deposit date:2016-02-24
Release date:2016-04-27
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:The crystal structure of Cpf1 in complex with CRISPR RNA
Nature, 532, 2016
5N1V
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CRYSTAL STRUCTURE OF THE PROTEIN KINASE CK2 CATALYTIC SUBUNIT IN COMPLEX WITH PYRAZOLO-PYRIMIDINE MACROCYCLIC LIGAND
Descriptor:Casein kinase II subunit alpha, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Robb, G., Ferguson, A., Hargreaves, D.
Deposit date:2017-02-06
Release date:2017-05-17
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J. Med. Chem., 60, 2017
5N1X
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CRYSTAL STRUCTURE OF THE BCL6 BTB DOMAIN IN COMPLEX WITH PYRAZOLO-PYRIMIDINE LIGAND
Descriptor:B-cell lymphoma 6 protein, ~{N}-ethyl-5-pyridin-3-yl-pyrazolo[1,5-a]pyrimidin-7-amine
Authors:Robb, G., Ferguson, A., Hargreaves, D.
Deposit date:2017-02-06
Release date:2017-05-17
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J. Med. Chem., 60, 2017
5N1Z
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CRYSTAL STRUCTURE OF THE BCL6 BTB DOMAIN IN COMPLEX WITH PYRAZOLO-PYRIMIDINE MACROCYCLIC LIGAND
Descriptor:B-cell lymphoma 6 protein, CHLORIDE ION, pyrazolo-pyrimidine macrocycle
Authors:Robb, G., Ferguson, A., Hargreaves, D.
Deposit date:2017-02-06
Release date:2017-05-17
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J. Med. Chem., 60, 2017
5N20
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CRYSTAL STRUCTURE OF THE BCL6 BTB DOMAIN IN COMPLEX WITH PYRAZOLO-PYRIMIDINE LIGAND
Descriptor:B-cell lymphoma 6 protein, ~{N}-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-[(3~{R})-3-(dimethylamino)pyrrolidin-1-yl]phenyl]ethanamide
Authors:Robb, G., Ferguson, A., Hargreaves, D.
Deposit date:2017-02-06
Release date:2017-05-17
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J. Med. Chem., 60, 2017