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1I0F
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1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-AMINOOXYETHYL THYMINE IN PLACE OF T6, BA-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(127)P*AP*CP*GP*C)-3', BARIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0G
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1.45 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, MEDIUM NA-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', SODIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0J
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1.06 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE (T23) THYMINE IN PLACE OF T6, HIGH CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0K
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1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0M
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1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, HIGH RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0N
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1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0O
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1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE THYMINE IN PLACE OF T6, HIGH K-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', POTASSIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments
Nucleic Acids Res., 29, 2001
1I0P
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1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)], MEDIUM K-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', POTASSIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0Q
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1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM NA-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', SODIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0T
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0.6 A STRUCTURE OF Z-DNA CGCGCG
Descriptor:5'-D(*CP*GP*CP*GP*CP*G)-3', SPERMINE
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.6 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1IG1
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1.8A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MN.
Descriptor:death-associated protein kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-04-16
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKK
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2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG.
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-12
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKL
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1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-12
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKS
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1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-13
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKT
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TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-13
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1KGK
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DIRECT OBSERVATION OF A CYTOSINE ANALOG THAT FORMS FIVE HYDROGEN BONDS TO GUANOSINE; GUANYL G-CLAMP
Descriptor:5'-D(*GP*(GCK)P*GP*TP*AP*TP*AP*CP*GP*C)-3', METHOXY-ETHOXYL, SPERMINE (FULLY PROTONATED FORM)
Authors:Wilds, C.J., Maier, M.A., Tereshko, V., Manoharan, M., Egli, M.
Deposit date:2001-11-27
Release date:2001-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Direct Observation of a Cytosine Analogue that Forms Five Hydrogen Bonds to Guanosine: Guanidino G-Clamp
Angew.Chem.Int.Ed.Engl., 41, 2002
1MA8
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A-DNA DECAMER GCGTA(UMS)ACGC WITH INCORPORATED 2'-METHYLSELENO-URIDINE
Descriptor:5'-D(*GP*CP*GP*TP*AP*UMSP*AP*CP*GP*C)-3'
Authors:Teplova, M., Wilds, C.J., Wawrzak, Z., Tereshko, V., Du, Q., Carrasco, N., Huang, Z., Egli, M.
Deposit date:2002-08-01
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle
BIOCHIMIE, 84, 2002
1MLX
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CRYSTAL STRUCTURE ANALYSIS OF A 2'-O-[2-(METHYLTHIO)-ETHYL]-MODIFIED OLIGODEOXYNUCLEOTIDE DUPLEX
Descriptor:5'-D(*GP*CP*GP*TP*AP*SMTP*AP*CP*GP*C)-3'
Authors:Prakash, T.P., Manoharan, M., Kawasaki, A.M., Fraser, A.S., Lesnik, E.A., Sioufi, N., Leeds, J.M., Teplova, M., Egli, M.
Deposit date:2002-08-31
Release date:2002-12-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA
Biochemistry, 41, 2002
1NZG
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CRYSTAL STRUCTURE OF A-DNA DECAMER GCGTA(3ME)ACGC, WITH A MODIFIED 5-METHYLURIDINE
Descriptor:5'-D(*GP*CP*GP*TP*AP*(3ME)P*AP*CP*GP*C)-3'
Authors:Prhavc, M., Prakash, T.P., Minasov, G., Egli, M., Manoharan, M.
Deposit date:2003-02-17
Release date:2003-08-26
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects
Org.Lett., 5, 2003
1P4F
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DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
Descriptor:Death-associated protein kinase 1, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE
Authors:Velentza, A.V., Wainwright, M.S., Zasadzki, M., Mirzoeva, S., Haiech, J., Focia, P.J., Egli, M., Watterson, D.M.
Deposit date:2003-04-23
Release date:2004-09-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Bioorg.Med.Chem.Lett., 13, 2003
1R3G
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1.16A X-RAY STRUCTURE OF THE SYNTHETIC DNA FRAGMENT WITH THE INCORPORATED 2'-O-[(2-GUANIDINIUM)ETHYL]-5-METHYLURIDINE RESIDUES
Descriptor:5'-D(*GP*CP*GP*TP*AP*(GMU)P*AP*CP*GP*C)-3'), MAGNESIUM ION
Authors:Prakash, T.P., Puschl, A., Lesnik, E., Tereshko, V., Egli, M., Manoharan, M.
Deposit date:2003-10-01
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:2'-O-[2-(Guanidinium)ethyl]-Modified Oligonucleotides: Stabilizing Effect on Duplex and Triplex Structures.
Org.Lett., 6, 2004
1XUW
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STRUCTURAL RATIONALIZATION OF A LARGE DIFFERENCE IN RNA AFFINITY DESPITE A SMALL DIFFERENCE IN CHEMISTRY BETWEEN TWO 2'-O-MODIFIED NUCLEIC ACID ANALOGS
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(NMT)P*AP*CP*GP*C)-3')
Authors:Pattanayek, R., Sethaphong, L., Pan, C., Prhavc, M., Prakash, T.P., Manoharan, M., Egli, M.
Deposit date:2004-10-26
Release date:2004-12-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
J.Am.Chem.Soc., 126, 2004
1XUX
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STRUCTURAL RATIONALIZATION OF A LARGE DIFFERENCE IN RNA AFFINITY DESPITE A SMALL DIFFERENCE IN CHEMISTRY BETWEEN TWO 2'-O-MODIFIED NUCLEIC ACID ANALOGS
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(NMS)P*AP*CP*GP*C)-3')
Authors:Pattanayek, R., Sethaphong, L., Pan, C., Prhavc, M., Prakash, T.P., Manoharan, M., Egli, M.
Deposit date:2004-10-26
Release date:2004-12-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
J.Am.Chem.Soc., 126, 2004
2AXB
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CRYSTAL STRUCTURE ANALYSIS OF A 2-O-[2-(METHOXY)ETHYL]-2-THIOTHYMIDINE MODIFIED OLIGODEOXYNUCLEOTIDE DUPLEX
Descriptor:5'-D(*GP*CP*GP*TP*AP*(S2M)P*AP*CP*GP*C)-3')
Authors:Diop-Frimpong, B., Prakash, T.P., Rajeev, K.G., Manoharan, M., Egli, M.
Deposit date:2005-09-04
Release date:2005-11-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.
Nucleic Acids Res., 33, 2005
2QEF
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X-RAY STRUCTURE OF 7-DEAZA-DG AND Z3DU MODIFIED DUPLEX CGCGAATXCZCG
Descriptor:DNA (5'-D(*DCP*DGP*DCP*DGP*DAP*DAP*DTP*(ZDU)P*DCP*(7GU)P*DCP*DG)-3')
Authors:Wang, F., Li, F., Ganguly, M., Marky, L.A., Gold, B., Egli, M., Stone, M.P.
Deposit date:2007-06-25
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.
Biochemistry, 47, 2008