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7Z05
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BU of 7z05 by Molmil
White Bream virus N7-Methyltransferase
Descriptor: DI(HYDROXYETHYL)ETHER, Non-structural protein 1, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Shannon, A, Gauffre, P, Canard, B, Ferron, F.
Deposit date:2022-02-22
Release date:2022-09-28
Last modified:2022-11-16
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome.
Nucleic Acids Res., 50, 2022
7Z2J
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BU of 7z2j by Molmil
White Bream virus N7-Methyltransferase
Descriptor: Non-structural protein 1, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Shannon, A, Gauffre, P, Canard, B, Ferron, F.
Deposit date:2022-02-28
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.657 Å)
Cite:A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome.
Nucleic Acids Res., 50, 2022
6YU8
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BU of 6yu8 by Molmil
RNA Methyltransferase of Sudan Ebola Virus
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Ferron, F, Valle, C, Zamboni, V, Canard, B, Decroly, E.
Deposit date:2020-04-25
Release date:2021-02-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:First insights into the structural features of Ebola virus methyltransferase activities.
Nucleic Acids Res., 49, 2021
8CB3
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BU of 8cb3 by Molmil
SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Papain-like protease nsp3
Authors:Morin, B, Ferron, F, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2023-01-25
Release date:2024-02-07
Method:X-RAY DIFFRACTION (1.572 Å)
Cite:SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid
To Be Published
6G13
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BU of 6g13 by Molmil
C-terminal domain of MERS-CoV nucleocapsid
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein, ...
Authors:Nguyen, T.H.V, Ferron, F.P, Lichiere, J, Canard, B, Papageorgiou, N, Coutard, B.
Deposit date:2018-03-20
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein.
Acta Crystallogr D Struct Biol, 75, 2019
8C0G
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BU of 8c0g by Molmil
SARS-CoV nsp16-nsp10 complexed with N7-GTP
Descriptor: DI(HYDROXYETHYL)ETHER, Non-structural protein 7, SODIUM ION, ...
Authors:Ferron, F, Debarnot, C, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2022-12-16
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Observation of N7-GTP in nsp16-nsp10 Sars-CoV
To Be Published
2CKW
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BU of 2ckw by Molmil
The 2.3 A resolution structure of the Sapporo virus RNA dependant RNA polymerase.
Descriptor: RNA-DIRECTED RNA POLYMERASE
Authors:Fullerton, S.W.B, Tucker, P.A, Rohayem, J, Coutard, B, Gebhardt, J, Gorbalenya, A, Canard, B.
Deposit date:2006-04-24
Release date:2006-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase.
J.Virol., 81, 2007
5FVA
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BU of 5fva by Molmil
Toscana Virus Nucleocapsid Protein
Descriptor: NUCLEOPROTEIN, SODIUM ION
Authors:Baklouti, A, Sevajol, M, Goulet, A, Lichiere, J, Ferron, F, Canard, B, Charrel, R.N, Coutard, B, Papageorgiou, N.
Deposit date:2016-02-03
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Toscana virus nucleoprotein oligomer organization observed in solution.
Acta Crystallogr D Struct Biol, 73, 2017
3RUO
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BU of 3ruo by Molmil
Complex structure of HevB EV93 main protease 3C with Rupintrivir (AG7088)
Descriptor: 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, CHLORIDE ION, HEVB EV93 3C PROTEASE, ...
Authors:Kaczmarska, Z, Janowski, R, Costenaro, L, Coutard, B, Norder, H, Canard, B, Coll, M.
Deposit date:2011-05-05
Release date:2011-09-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93.
J.Virol., 85, 2011
8BCR
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BU of 8bcr by Molmil
DENV3 Methyltransferase in complexed with AT-9010 and SAH
Descriptor: Genome polyprotein, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Gauffre, P, Fattorini, V, Canard, B, Ferron, F.
Deposit date:2022-10-17
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.
Antiviral Res., 212, 2023
7ED5
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BU of 7ed5 by Molmil
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B.
Deposit date:2021-03-15
Release date:2022-02-16
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Nat Commun, 13, 2022
1OKS
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BU of 1oks by Molmil
Crystal structure of the measles virus phosphoprotein XD domain
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, RNA POLYMERASE ALPHA SUBUNIT
Authors:Johansson, K, Bourhis, J.-M, Campanacci, V, Cambillau, C, Canard, B, Longhi, S.
Deposit date:2003-07-29
Release date:2003-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Measles Virus Phosphoprotein Domain Responsible for the Induced Folding of the C-Terminal Domain of the Nucleoprotein
J.Biol.Chem., 278, 2003
1F3F
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BU of 1f3f by Molmil
STRUCTURE OF THE H122G NUCLEOSIDE DIPHOSPHATE KINASE / D4T-TRIPHOSPHATE.MG COMPLEX
Descriptor: 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-DIPHOSPHATE, 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Meyer, P, Schneider, B, Sarfati, S, Deville-Bonne, D, Guerreiro, C, Boretto, J, Janin, J, Veron, M, Canard, B.
Deposit date:2000-06-02
Release date:2000-09-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
1F6T
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BU of 1f6t by Molmil
STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX
Descriptor: 2*-DEOXY-THYMIDINE-5*-ALPHA BORANO DIPHOSPHATE (ISOMER RP), MAGNESIUM ION, PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE)
Authors:Guerreiro, C, Boretto, J, Janin, J, Veron, M, Canard, B, Schneider, B, Sarfati, S, Deville-Bonne, D.
Deposit date:2000-06-23
Release date:2000-09-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
1L9K
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BU of 1l9k by Molmil
dengue methyltransferase
Descriptor: RNA-DIRECTED RNA POLYMERASE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Egloff, M.P, Benarroch, D, Selisko, B, Romette, J.L, Canard, B.
Deposit date:2002-03-25
Release date:2003-03-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21, 2002
1MN9
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BU of 1mn9 by Molmil
NDP kinase mutant (H122G) complex with RTP
Descriptor: MAGNESIUM ION, NDP kinase, RIBAVIRIN TRIPHOSPHATE
Authors:Gallois-montbrun, S, Chen, Y, Dutartre, H, Morera, S, Guerreiro, C, Mulard, L, Schneider, B, Janin, J, Canard, B, Veron, M, Deville-bonne, D.
Deposit date:2002-09-05
Release date:2003-03-18
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets
MOL.PHARMACOL., 63, 2003
5T2T
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BU of 5t2t by Molmil
Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001
Descriptor: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F.
Deposit date:2016-08-24
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.967 Å)
Cite:Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
IUCrJ, 5, 2018
1R6A
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BU of 1r6a by Molmil
Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Descriptor: Genome polyprotein, RIBAVIRIN MONOPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Benarroch, D, Egloff, M.P, Mulard, L, Romette, J.L, Canard, B.
Deposit date:2003-10-15
Release date:2004-09-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.
J.Biol.Chem., 279, 2004
1QZ8
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BU of 1qz8 by Molmil
Crystal structure of SARS coronavirus NSP9
Descriptor: SULFATE ION, polyprotein 1ab
Authors:Egloff, M.P, Ferron, F, Campanacci, V, Longhi, S, Rancurel, C, Dutartre, H, Snijder, E.J, Gorbalenya, A.E, Cambillau, C, Canard, B.
Deposit date:2003-09-16
Release date:2004-02-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.
Proc.Natl.Acad.Sci.USA, 101, 2004
4TU0
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BU of 4tu0 by Molmil
CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER
Descriptor: 2'-5' OLIGOADENYLATE TRIMER, DI(HYDROXYETHYL)ETHER, Non-structural polyprotein 3
Authors:Morin, B, Ferron, f.p, Malet, h, Coutard, b, Canard, b.
Deposit date:2014-06-23
Release date:2014-07-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER
TO BE PUBLISHED
4C6A
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BU of 4c6a by Molmil
High Resolution Structure of the Nucleoside diphosphate kinase
Descriptor: DI(HYDROXYETHYL)ETHER, NUCLEOSIDE DIPHOSPHATE KINASE, CYTOSOLIC
Authors:Priet, S, Ferron, F, Alvarez, K, Verron, M, Canard, B.
Deposit date:2013-09-18
Release date:2013-11-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Enzymatic Synthesis of Acyclic Nucleoside Thiophosphonate Diphosphates: Effect of the Alpha-Phosphorus Configuration on HIV-1 RT Activity.
Antiviral Res., 117, 2015
4CP5
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BU of 4cp5 by Molmil
ndpK in complex with (Rp)-SPMPApp
Descriptor: NUCLEOSIDE DIPHOSPHATE KINASE, CYTOSOLIC, [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-sulfanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Priet, S, Ferron, F, Alvarez, K, Verron, M, Canard, B.
Deposit date:2014-01-31
Release date:2015-02-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Enzymatic Synthesis of Acyclic Nucleoside Thiophosphonate Diphosphates: Effect of the Alpha-Phosphorus Configuration on HIV-1 RT Activity.
Antiviral Res., 117, 2015
3OV9
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BU of 3ov9 by Molmil
Structure of the Nucleoprotein from Rift Valley Fever Virus
Descriptor: NITRITE ION, Nucleoprotein, SODIUM ION
Authors:Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J.
Deposit date:2010-09-16
Release date:2011-05-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
3OUO
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BU of 3ouo by Molmil
Structure of the Nucleoprotein from Rift Valley Fever Virus
Descriptor: NITRITE ION, Nucleoprotein
Authors:Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J.
Deposit date:2010-09-15
Release date:2011-05-25
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
3Q3X
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BU of 3q3x by Molmil
Crystal structure of the main protease (3C) from human enterovirus B EV93
Descriptor: GLYCEROL, HEVB EV93 3C protease, MAGNESIUM ION
Authors:Costenaro, L, Sola, M, Coutard, B, Norder, H, Canard, B, Coll, M.
Deposit date:2010-12-22
Release date:2011-09-07
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93.
J.Virol., 85, 2011

217705

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