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3D9Z
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-05-28
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DAZ
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-05-30
公開日2009-03-03
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DBU
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-02
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DC3
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DC9
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DCC
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DCS
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-04
公開日2009-03-03
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DCW
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-04
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DD0
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-04
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3HS4
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL, ...
著者Robbins, A.H., Genis, C., Domsic, J., Sippel, K.H., Agbandje-McKenna, M., McKenna, R.
登録日2009-06-10
公開日2009-12-08
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design.
Acta Crystallogr.,Sect.F, 65, 2009
3NG9
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STRUCTURE TO FUNCTION CORRELATIONS FOR ADENO-ASSOCIATED VIRUS SEROTYPE 1
分子名称:Capsid protein, ADENINE, 6-AMINOPYRIMIDIN-2(1H)-ONE
著者Govindasamy, L., Miller, E.B., Gurda, B., McKenna, R., Zolotukhin, S., Muzyczka, N., Agbandje-McKenna, M.
登録日2010-06-11
公開日2011-12-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure to Function Correlations for Adeno-Associated Virus serotype 1
To be Published
3NTT
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STRUCTURAL INSIGHTS OF ADENO-ASSOCIATED VIRUS 5. A GENE THERAPY VECTOR FOR CYSTIC FIBROSIS
分子名称:Capsid protein, GLYCEROL, SODIUM ION
著者Govindasamy, L., DiMattia, M., Chiorini, J.A., McKenna, R., Muzyczka, N., Agbandje-McKenna, M.
登録日2010-07-05
公開日2011-12-07
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structural insights into adeno-associated virus serotype 5.
J.Virol., 87, 2013
3OAH
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STRUCTURAL CHARACTERIZATION OF THE DUAL GLYCAN BINDING ADENO-ASSOCIATED VIRUS SEROTYPE 6
分子名称:Capsid protein VP1, 6-AMINOPYRIMIDIN-2(1H)-ONE, 9-(2-deoxy-5-O-phosphono-alpha-D-threo-pentofuranosyl)-9H-purin-6-amine
著者Ng, R., Agbandje-McKenna, M.
登録日2010-08-05
公開日2011-03-23
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural characterization of the dual glycan binding adeno-associated virus serotype 6.
J.Virol., 84, 2010
4IOV
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THE STRUCTURE OF AAVRH32.33, A NOVEL GENE DELIVERY VECTOR
分子名称:Capsid protein VP1, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE
著者Mikalism, K., Nam, H.-J., Van vilet, K., Vandenberghe, L.H., Mays, L.E., McKenna, R., Wilson, J., Agbandje-McKenna, M.
登録日2013-01-08
公開日2014-04-02
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献The structure of AAVrh32.33, a novel gene delivery vector.
J.Struct.Biol., 186, 2014
4QC8
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STRUCTURAL ANNOTATION OF PATHOGENIC BOVINE PARVOVIRUS-1
分子名称:VP2
著者Kailasan, S., Halder, S., Gurda, B.L., Bladek, H., Chipman, P.R., McKenna, R., Brown, K., Agbandje-McKenna, M.
登録日2014-05-09
公開日2015-01-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of an enteric pathogen, bovine parvovirus.
J.Virol., 89, 2015
4RSO
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THE STRUCTURE OF THE NEUROTROPIC AAVRH.8 VIRAL VECTOR
分子名称:Capsid protein VP1, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, SODIUM ION, ...
著者Halder, S., Van Vliet, K., Smith, J.K., McKenna, R., Wilson, J.M., Agbandje-McKenna, M.
登録日2014-11-10
公開日2016-04-13
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure of neurotropic adeno-associated virus AAVrh.8.
J.Struct.Biol., 192, 2015
5EGC
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STRUCTURE OF THE ADENO-ASSOCIATED VIRUS SEROTYPE 1 SIALIC ACID COMPLEX
分子名称:Capsid protein, O-SIALIC ACID, MAGNESIUM ION
著者Huang, L.Y., Agbandje-McKenna, M.
登録日2015-10-27
公開日2016-03-23
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (3.011 Å)
主引用文献Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.
J.Virol., 90, 2016
5IPI
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STRUCTURE OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
分子名称:Capsid protein VP1
著者Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
登録日2016-03-09
公開日2016-07-20
最終更新日2017-09-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
5IPK
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STRUCTURE OF THE R432A VARIANT OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
分子名称:Capsid protein VP1
著者Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
登録日2016-03-09
公開日2016-07-20
最終更新日2017-09-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
6B9Q
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SINGLE PARTICLE CRYO-EM STRUCTURE DETERMINATION OF THE LUIII CAPSID PROTEIN
分子名称:Capsid protein VP2
著者Pittman, N.C., Agbandje-McKenna, M.
登録日2017-10-11
公開日2017-11-15
最終更新日2017-12-06
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction.
Viruses, 9, 2017
3EKI
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STRUCTURAL INSIGHTS OF THE MYCOPLASMA HYORHINIS PROTEIN MH-P37: A PUTATIVE THIAMINE PYROPHOSPHATE TRANSPORTER
分子名称:High affinity transport system protein p37, THIAMINE DIPHOSPHATE, GLYCEROL, ...
著者Sippel, K.H., Robbins, A.H., Reutzel, R., McKenna, R.
登録日2008-09-19
公開日2009-06-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis
J.Bacteriol., 191, 2009
2AX2
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PRODUCTION AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF FULLY DEUTERATED HUMAN CARBONIC ANHYDRASE II
分子名称:Carbonic anhydrase II, ZINC ION
著者Budayova-Spano, M., Fisher, S.Z., Dauvergne, M.T., Silverman, D.N., Myles, D.A.A., McKenna, R.M.
登録日2005-09-02
公開日2006-01-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
Acta Crystallogr.,Sect.F, 62, 2006
1G0E
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SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE
分子名称:CARBONIC ANHYDRASE II, ZINC ION, MERCURY (II) ION, ...
著者Duda, D., McKenna, R.
登録日2000-10-06
公開日2000-10-18
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.
Biochemistry, 40, 2001
1G0F
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SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II
分子名称:CARBONIC ANHYDRASE II, ZINC ION, MERCURY (II) ION
著者Duda, D., McKenna, R.
登録日2000-10-06
公開日2000-10-18
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.
Biochemistry, 40, 2001
1SGU
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COMPARING THE ACCUMULATION OF ACTIVE SITE AND NON-ACTIVE SITE MUTATIONS IN THE HIV-1 PROTEASE
分子名称:POL polyprotein, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
著者Clemente, J.C., Moose, R.E., Hemrajani, R., Govindasamy, L., Reutzel, R., Mckenna, R., Abandje-McKenna, M., Goodenow, M.M., Dunn, B.M.
登録日2004-02-24
公開日2004-10-05
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease.
Biochemistry, 43, 2004