Author results

4QLI
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A NOVEL PHOSPHO-SWITCH IN THE LINKER REGION OF THE SNAIL ZINC FINGER PROTEIN WHICH REGULATES 14-3-3 ASSOCIATION, DNA BINDING AND EPITHELIAL-MESENCHYMAL DIFFERENTIATION
分子名称:14-3-3 protein sigma, Zinc finger protein SNAI1, MAGNESIUM ION, ...
著者Bier, D., Ottmann, C.
登録日2014-06-12
公開日2015-06-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published
5D2R
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INHIBITOR BOUND CELL SHAPE DETERMINANT PROTEIN CSD4 FROM HELICOBACTER PYLORI
分子名称:Conserved hypothetical secreted protein, ZINC ION, IODIDE ION, ...
著者Chan, A.C., Murphy, M.E.
登録日2015-08-06
公開日2016-01-20
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Bacterial Cell Shape-Determining Inhibitor.
Acs Chem.Biol., 11, 2016
5OI7
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HUMAN CEP85 - COILED COIL DOMAIN 4
分子名称:Centrosomal protein of 85 kDa, (4S)-2-METHYL-2,4-PENTANEDIOL
著者van Breugel, M.
登録日2017-07-18
公開日2018-04-18
最終更新日2018-05-09
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Nat Commun, 9, 2018
5OI9
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TRICHOPLAX ADHAERENS STIL N-TERMINAL DOMAIN
分子名称:Putative uncharacterized protein, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者van Breugel, M.
登録日2017-07-18
公開日2018-04-18
最終更新日2018-05-09
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Nat Commun, 9, 2018
5OID
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COMPLEX TRICHOPLAX STIL-NTD:HUMAN CEP85 COILED COIL DOMAIN 4
分子名称:Putative uncharacterized protein, Centrosomal protein of 85 kDa
著者van Breugel, M.
登録日2017-07-18
公開日2018-04-18
最終更新日2018-05-09
実験手法X-RAY DIFFRACTION (4.6 Å)
主引用文献Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Nat Commun, 9, 2018
5UG0
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HUMAN ANTIBODY H2897 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ H1 SOLOMON ISLANDS/03/2006
分子名称:Hemagglutinin HA1, Hemagglutinin HA2, 2897 light chain, ...
著者Raymond, D.D., Caradonna, T., Schmidt, A.G., Harrison, S.C.
登録日2017-01-06
公開日2017-05-31
最終更新日2017-06-21
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface.
J. Mol. Biol., 429, 2017
5VNP
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X-RAY CRYSTAL STRUCTURE OF HALOTAG BOUND TO THE P1 BENZOXADIAZOLE FLUOROGENIC LIGAND
分子名称:Haloalkane dehalogenase, N-{2-[2-(hexyloxy)ethoxy]ethyl}-N~2~-methyl-N~2~-{[7-(methylamino)-2,1,3-benzoxadiazol-4-yl]sulfonyl}glycinamide, CHLORIDE ION
著者Dunham, N.P., Boal, A.K.
登録日2017-05-01
公開日2017-06-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress.
Angew. Chem. Int. Ed. Engl., 56, 2017
5YVT
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CRYSTAL STRUCTURE OF THE ALPHA GAMMA HETERODIMER OF HUMAN IDH3 IN COMPLEX WITH MG(2+) AND NADH
分子名称:Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, ...
著者Ma, T., Ding, J.
登録日2017-11-27
公開日2018-03-14
最終更新日2018-03-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Insights into the inhibitory mechanisms of NADH on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
Sci Rep, 8, 2018
3LQQ
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STRUCTURE OF THE CED-4 APOPTOSOME
分子名称:Cell death protein 4, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Qi, S., Pang, Y., Shi, Y., Yan, N., Liu, Q.
登録日2010-02-09
公開日2010-04-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.534 Å)
主引用文献Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.
Cell(Cambridge,Mass.), 141, 2010
3PUQ
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CEKDM7A FROM C.ELEGANS, COMPLEX WITH ALPHA-KG
分子名称:Lysine-specific demethylase 7 homolog, FE (II) ION, ZINC ION, ...
著者Yang, Y., Wang, P., Xu, W., Xu, Y.
登録日2010-12-06
公開日2011-01-26
最終更新日2012-03-28
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
Cancer Cell, 19, 2011
3PUR
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CEKDM7A FROM C.ELEGANS, COMPLEX WITH D-2-HG
分子名称:Lysine-specific demethylase 7 homolog, FE (II) ION, ZINC ION, ...
著者Yang, Y., Wang, P., Xu, W., Xu, Y.
登録日2010-12-06
公開日2011-01-26
最終更新日2012-03-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
Cancer Cell, 19, 2011
6A3V
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COMPLEX STRUCTURE OF HUMAN 4-1BB AND 4-1BBL
分子名称:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE
著者Li, Y., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
登録日2018-06-17
公開日2018-10-10
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (3.391 Å)
主引用文献Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
6A3W
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COMPLEX STRUCTURE OF 4-1BB AND UTOMILUMAB
分子名称:utomilumab VH, utomilumab VL, Tumor necrosis factor receptor superfamily member 9, ...
著者Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
登録日2018-06-17
公開日2018-10-10
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
6A50
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STRUCTURE OF BENZOYLFORMATE DECARBOXYLASES IN COMPLEX WITH COFACTOR TPP
分子名称:benzoylformate decarboxylases, MAGNESIUM ION, THIAMINE DIPHOSPHATE
著者Guo, Y., Wang, S., Nie, Y., Li, S.
登録日2018-06-21
公開日2019-02-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Synthetic Pathway for Acetyl-Coenzyme A Biosynthesis
Nat Commun, 2019
1J4J
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CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN (FORM II) COMPLEXED WITH AN ACYL COENZYME A
分子名称:TABTOXIN RESISTANCE PROTEIN, ACETYL COENZYME *A
著者He, H., Ding, Y., Bartlam, M., Zhang, R., Duke, N., Joachimiak, A., Shao, Y., Cao, Z., Tang, H., Liu, Y., Jiang, F., Liu, J., Zhao, N., Rao, Z.
登録日2001-10-02
公開日2003-06-03
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation.
J.Mol.Biol., 325, 2003
4KFP
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IDENTIFICATION OF 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE-DERIVED UREAS AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, PHOSPHATE ION, ...
著者Dragovich, P.S., Bair, K.W., Baumeister, T., Ho, Y., Liederer, B.M., Liu, X., O'Brien, T., Oeh, J., Sampath, D., Skelton, N., Wang, L., Wang, W., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhang, L., Zheng, X.
登録日2013-04-27
公開日2013-08-14
最終更新日2013-08-21
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4Y5U
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TRANSCRIPTION FACTOR
分子名称:Signal transducer and activator of transcription 6, NICKEL (II) ION
著者Li, J., Niu, F., Ouyang, S., Liu, Z.
登録日2015-02-12
公開日2016-02-17
最終更新日2016-11-30
実験手法X-RAY DIFFRACTION (2.708 Å)
主引用文献Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
4Y5W
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TRANSCRIPTION FACTOR-DNA COMPLEX
分子名称:Signal transducer and activator of transcription 6, DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3')
著者Li, J., Niu, F., Ouyang, S., Liu, Z.
登録日2015-02-12
公開日2016-02-17
最終更新日2016-11-30
実験手法X-RAY DIFFRACTION (3.104 Å)
主引用文献Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
5D39
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TRANSCRIPTION FACTOR-DNA COMPLEX
分子名称:Signal transducer and activator of transcription 6, DNA (5'-D(P*TP*CP*TP*GP*TP*CP*TP*TP*CP*CP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*GP*GP*AP*AP*GP*AP*CP*AP*GP*A)-3')
著者Li, J., Niu, F., Ouyang, S., Liu, Z.
登録日2015-08-06
公開日2016-08-10
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
5I2K
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH 7-{[ETHYL(4-FLUOROPHENYL)AMINO]METHYL}-N,2-DIMETHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 19)
分子名称:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
著者Wallweber, H.J.A., Lupardus, P.J.
登録日2016-02-09
公開日2016-03-16
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5I2N
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH N-ETHYL-7-{[2-FLUORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL}-2-METHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 29)
分子名称:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
著者Wallweber, H.J.A., Lupardus, P.J.
登録日2016-02-09
公開日2016-03-16
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5KDT
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH GNE0723
分子名称:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
著者Wallweber, H.J.A., Lupardus, P.J.
登録日2016-06-08
公開日2016-07-13
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J. Med. Chem., 59, 2016
4G42
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STRUCTURE OF THE CHICKEN MHC CLASS I MOLECULE BF2*0401 COMPLEXED TO PEPITDE P8D
分子名称:MHC class I alpha chain 2, Beta-2 microglobulin, 8-MERIC PEPTIDE P8D
著者Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F.
登録日2012-07-16
公開日2012-11-21
実験手法X-RAY DIFFRACTION (2.294 Å)
主引用文献Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens.
J.Immunol., 189, 2012
4G43
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STRUCTURE OF THE CHICKEN MHC CLASS I MOLECULE BF2*0401 COMPLEXED TO P5E
分子名称:MHC class I alpha chain 2, Beta-2 microglobulin, 8-MERIC PEPTIDE P5E, ...
著者Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F.
登録日2012-07-16
公開日2012-11-21
実験手法X-RAY DIFFRACTION (1.803 Å)
主引用文献Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens.
J.Immunol., 189, 2012
5YJ8
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IDENTIFICATION OF A SMALL MOLECULE INHIBITOR FOR THE TUDOR DOMAIN OF TDRD3
分子名称:Tudor domain-containing protein 3, 5-(aminomethyl)-1,3-dimethyl-benzimidazol-2-one, SULFATE ION
著者Liu, J., Ruan, K.
登録日2017-10-09
公開日2018-05-02
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.
FEBS J., 285, 2018