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1BVH
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BU of 1bvh by Molmil
SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
Descriptor: ACID PHOSPHATASE
Authors:Logan, T.M, Zhou, M.-M, Nettesheim, D.G, Meadows, R.P, Van Etten, R.L, Fesik, S.W.
Deposit date:1994-05-03
Release date:1994-07-31
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
1JM4
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BU of 1jm4 by Molmil
NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide
Descriptor: HIV-1 Tat Peptide, P300/CBP-associated Factor
Authors:Mujtaba, S, He, Y, Zeng, L, Farooq, A, Carlson, J.E, Ott, M, Verdin, E, Zhou, M.-M.
Deposit date:2001-07-17
Release date:2002-07-17
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
Mol.Cell, 9, 2002
2AQE
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BU of 2aqe by Molmil
Structural and functional analysis of ada2 alpha swirm domain
Descriptor: Transcriptional adaptor 2, Ada2 alpha
Authors:Qian, C, Zhang, Q, Zeng, L, Zhou, M.-M.
Deposit date:2005-08-17
Release date:2005-12-13
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure and chromosomal DNA binding of the SWIRM domain
Nat.Struct.Mol.Biol., 12, 2005
1M3G
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BU of 1m3g by Molmil
SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF MAPK PHOSPHATASE PAC-1: INSIGHTS INTO SUBSTRATE-INDUCED ENZYMATIC ACTIVATION
Descriptor: DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
Authors:Farooq, A, Zhou, M.-M.
Deposit date:2002-06-27
Release date:2003-06-27
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Solution Structure of the MAPK Phosphatase PAC-1 Catalytic Domain Insights into Substrate-Induced Enzymatic Activation of MKP
Structure, 11, 2003
1N3H
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BU of 1n3h by Molmil
Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Descriptor: SHC Transforming protein
Authors:Farooq, A, Zeng, L, Yan, K.S, Ravichandran, K.S, Zhou, M.-M.
Deposit date:2002-10-28
Release date:2003-10-28
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Structure, 11, 2003
1N3J
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BU of 1n3j by Molmil
Structure and Substrate of a Histone H3 Lysine Methyltransferase from Paramecium Bursaria Chlorella Virus 1
Descriptor: Histone H3 Lysine Methyltransferase
Authors:Manzur, K.L, Farooq, A, Zeng, L, Plotnikova, O, Sachchidanand, Koch, A.W, Zhou, M.-M.
Deposit date:2002-10-28
Release date:2003-01-28
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.
Nat.Struct.Biol., 10, 2003
1N72
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BU of 1n72 by Molmil
Structure and Ligand of a Histone Acetyltransferase Bromodomain
Descriptor: HISTONE ACETYLTRANSFERASE
Authors:Dhalluin, C, Carlson, J.E, Zeng, L, He, C, Aggarwal, A.K, Zhou, M.-M.
Deposit date:2002-11-12
Release date:2002-12-11
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structure and Ligand of a Histone Acetyltransferase Bromodomain
Nature, 399, 1999
1OP4
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BU of 1op4 by Molmil
Solution Structure of Neural Cadherin Prodomain
Descriptor: Neural-cadherin
Authors:Koch, A.W, Farooq, A, Shan, W, Zeng, L, Colman, D.R, Zhou, M.-M.
Deposit date:2003-03-04
Release date:2004-03-16
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structure of the Neural (N-) Cadherin Prodomain Reveals a Cadherin Extracellular Domain-like Fold without Adhesive Characteristics
Structure, 12, 2004
1XR0
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BU of 1xr0 by Molmil
Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Descriptor: Basic fibroblast growth factor receptor 1, FGFR signalling adaptor SNT-1
Authors:Dhalluin, C, Yan, K.S, Plotnikova, O, Lee, K.W, Zeng, L, Kuti, M, Mujtaba, S, Goldfarb, M.P, Zhou, M.-M.
Deposit date:2004-10-13
Release date:2004-11-02
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Mol.Cell, 6, 2000
1OY2
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BU of 1oy2 by Molmil
Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Descriptor: SHC transforming protein
Authors:Farooq, A, Zeng, L, Yan, K.S, Ravichandran, K.S, Zhou, M.-M.
Deposit date:2003-04-03
Release date:2004-04-06
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Structure, 11, 2003
1R4K
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BU of 1r4k by Molmil
Solution Structure of the Drosophila Argonaute 1 PAZ Domain
Descriptor: Argonaute 1
Authors:Yan, K.S, Yan, S, Farooq, A, Han, A, Zeng, L, Zhou, M.-M.
Deposit date:2003-10-07
Release date:2003-12-09
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure and conserved RNA binding of the PAZ domain
Nature, 426, 2003
4NUC
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BU of 4nuc by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS435 inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, J, Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUE
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BU of 4nue by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, J, Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUD
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BU of 4nud by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, J, Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
7XFG
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BU of 7xfg by Molmil
NMR solution structures of p300 TAZ2 domain in complex with BRD4-NUT F1c domain binding motif #1
Descriptor: Histone acetyltransferase p300, NUT family member 1, ZINC ION
Authors:Yu, D, Zeng, L, Zhou, M.-M.
Deposit date:2022-04-01
Release date:2023-04-12
Method:SOLUTION NMR
Cite:Structural Mechanism of BRD4-NUT Fusion Protein in p300-Activated Hyperacetylation
To Be Published
7XEZ
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BU of 7xez by Molmil
NMR solution structures of p300 TAZ2 domain in complex with BRD4-NUT F1c domain binding motif #2
Descriptor: Histone acetyltransferase p300,NUT family member 1, ZINC ION
Authors:Yu, D, Zeng, L, Zhou, M.-M.
Deposit date:2022-03-31
Release date:2023-04-12
Method:SOLUTION NMR
Cite:Structural Mechanism of BRD4-NUT Fusion Protein in p300-Activated Hyperacetylation
To Be Published
1SHC
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BU of 1shc by Molmil
SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: SHC, TRKA RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M, Ravichandran, K.S, Olejniczak, E.T, Petros, A.M, Meadows, R.P, Sattler, M, Harlan, J.E, Wade, W.S, Burakoff, S.J, Fesik, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995
1IRS
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BU of 1irs by Molmil
IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: IL-4 RECEPTOR PHOSPHOPEPTIDE, IRS-1
Authors:Zhou, M.-M, Huang, B, Olejniczak, E.T, Meadows, R.P, Shuker, S.B, Miyazaki, M, Trub, T, Shoelson, S.E, Feisk, S.W.
Deposit date:1996-03-22
Release date:1997-05-15
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1TCE
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BU of 1tce by Molmil
SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE
Descriptor: PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR, SHC
Authors:Zhou, M.-M, Meadows, R.P, Logan, T.M, Yoon, H.S, Wade, W.R, Ravichandran, K.S, Burakoff, S.J, Feisk, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
6BNH
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BU of 6bnh by Molmil
Solution NMR structures of BRD4 ET domain with JMJD6 peptide
Descriptor: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Bromodomain-containing protein 4
Authors:Konuma, T, Yu, D, Zhao, C, Ju, Y, Sharma, R, Ren, C, Zhang, Q, Zhou, M.-M, Zeng, L.
Deposit date:2017-11-16
Release date:2017-12-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.
Sci Rep, 7, 2017
2AQF
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BU of 2aqf by Molmil
Structural and functional analysis of ADA2 alpha swirm domain
Descriptor: transcriptional adaptor 2, Ada2 alpha
Authors:Qian, C, Zhang, Q, Zhou, M.-M, Zeng, L.
Deposit date:2005-08-17
Release date:2006-01-31
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure and chromosomal DNA binding of the SWIRM domain.
Nat.Struct.Mol.Biol., 12, 2005
8I60
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BU of 8i60 by Molmil
Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr
Descriptor: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ...
Authors:Konuma, T, Zhou, M.-M.
Deposit date:2023-01-26
Release date:2023-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Mol.Cell, 83, 2023
4F3I
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BU of 4f3i by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
Authors:Joshua, J, Zhou, M.-M, Plotnikov, A.N.
Deposit date:2012-05-09
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.
J.Biol.Chem., 287, 2012
5ULA
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BU of 5ula by Molmil
Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402
Descriptor: 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, j, Zhou, M.-M.
Deposit date:2017-01-24
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3QB8
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BU of 3qb8 by Molmil
Paramecium Chlorella Bursaria Virus1 Putative ORF A654L is a Polyamine Acetyltransferase
Descriptor: A654L protein, COENZYME A, IMIDAZOLE
Authors:Charlop-Powers, Z, Zhou, M.-M, Jakoncic, J, Gurnon, J, Van Etten, J.
Deposit date:2011-01-12
Release date:2012-01-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase.
J. Biol. Chem., 287, 2012

 

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