Author results

6IEZ
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND B16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-({4'-pentyl-3'-[2-(pyridin-2-yl)ethyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-09-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6IF0
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND D16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-({4'-pentyl-3'-[(Z)-2-(pyridin-2-yl)ethenyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-09-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6J0O
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND SC1
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[2-fluoranyl-5-[3-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]phenyl]phenyl]sulfonylethanol, UNKNOWN ATOM OR ION
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-12-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6J81
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E14
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-propyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2019-01-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6JIB
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HUMAN MTHFD2 IN COMPLEX WITH DS44960156
Descriptor:Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 4-(5-oxo-1,5-dihydro-2H-[1]benzopyrano[3,4-c]pyridine-3(4H)-carbonyl)benzoic acid, ...
Authors:Suzuki, M., Matsui, Y., Kawai, J.
Deposit date:2019-02-20
Release date:2019-06-05
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Acs Med.Chem.Lett., 10, 2019
6JID
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HUMAN MTHFD2 IN COMPLEX WITH COMPOUND 1
Descriptor:Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 5-(4-oxo-2-phenyl-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carbonyl)-1,3-dihydro-2H-2lambda~6~,1-benzothiazole-2,2-dione, ...
Authors:Suzuki, M., Matsui, Y., Matsuhashi, N., Kawai, J.
Deposit date:2019-02-20
Release date:2019-06-05
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Acs Med.Chem.Lett., 10, 2019
1V3X
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-[6-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO(5,4-C)PYRIDIN-2-YL] CARBONYL-2-CARBAMOYL-4-(6-CHLORONAPHTH-2-YLSULPHONYL)PIPERAZINE
Descriptor:Coagulation factor X, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Suzuki, M.
Deposit date:2003-11-07
Release date:2004-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element
J.Med.Chem., 47, 2004
2F08
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CRYSTAL STRUCTURE OF A MAJOR HOUSE DUST MITE ALLERGEN, DERF 2
Descriptor:mite allergen Der f II, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL
Authors:Mikami, B., Tanaka, Y., Minato, N., Suzuki, M., Korematsu, S.
Deposit date:2005-11-12
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and some properties of a major house dust mite allergen, Derf 2
Biochem.Biophys.Res.Commun., 339, 2006
3IIT
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FACTOR XA IN COMPLEX WITH A CIS-1,2-DIAMINOCYCLOHEXANE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M.
Deposit date:2009-08-03
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg.Med.Chem., 17, 2009
4QBJ
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CRYSTAL STRUCTURE OF N-MYRISTOYL TRANSFERASE FROM ASPERGILLUS FUMIGATUS COMPLEXED WITH A SYNTHETIC INHIBITOR
Descriptor:Glycylpeptide N-tetradecanoyltransferase, SULFATE ION, S-(2-OXO)PENTADECYLCOA, ...
Authors:Suzuki, M., Shimada, T.
Deposit date:2014-05-08
Release date:2015-04-01
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of N-myristoyltransferase from Aspergillus fumigatus
Acta Crystallogr.,Sect.D, 71, 2015
2DPF
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CRYSTAL STRUCTURE OF CURCULIN1 HOMODIMER
Descriptor:Curculin, SULFATE ION
Authors:Kurimoto, E., Suzuki, M., Amemiya, E., Yamaguchi, Y., Nirasawa, S., Shimba, N., Xu, N., Kashiwagi, T., Kawai, M., Suzuki, E., Kato, K.
Deposit date:2006-05-11
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Curculin Exhibits Sweet-tasting and Taste-modifying Activities through Its Distinct Molecular Surfaces.
J.Biol.Chem., 282, 2007
5GVO
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SOLUTION NMR STRUCTURE OF A NEW LASSO PEPTIDE SPHAERICIN
Descriptor:Uncharacterized protein
Authors:Hemmi, H., Kodani, S., Inoue, Y., Suzuki, M., Dohra, H., Suzuki, T., Ohnishi-Kameyama, M.
Deposit date:2016-09-06
Release date:2017-04-05
Method:SOLUTION NMR
Cite:Sphaericin, a Lasso Peptide from the Rare Actinomycete Planomonospora sphaerica
Eur.J.Org.Chem., 2017
5Y5N
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CRYSTAL STRUCTURE OF HUMAN SIRTUIN 2 IN COMPLEX WITH A SELECTIVE INHIBITOR
Descriptor:NAD-dependent protein deacetylase sirtuin-2, ZINC ION, 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide
Authors:Mellini, P., Itoh, Y., Tsumoto, H., Li, Y., Suzuki, M., Tokuda, N., Kakizawa, T., Miura, Y., Takeuchi, J., Lahtela-Kakkonen, M., Suzuki, T.
Deposit date:2017-08-09
Release date:2017-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Potent Mechanism-Based Sirtuin-2-Selective Inhibition by an In-Situ-Generated Occupant of the "Selectivity Pocket", Substrate Binding Site, and NAD+ Binding Pocket
CHEM SCI, 8, 2017
2CZQ
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A NOVEL CUTINASE-LIKE PROTEIN FROM CRYPTOCOCCUS SP.
Descriptor:cutinase-like protein, CITRIC ACID, 1,2-ETHANEDIOL
Authors:Masaki, K., Kamini, N.R., Ikeda, H., Iefuji, H., Kondo, H., Suzuki, M., Tsuda, S.
Deposit date:2005-07-14
Release date:2006-07-14
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Crystal structure and enhanced activity of a cutinase-like enzyme from Cryptococcus sp. strain S-2
Proteins, 77, 2009
1SQJ
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CRYSTAL STRUCTURE ANALYSIS OF OLIGOXYLOGLUCAN REDUCING-END-SPECIFIC CELLOBIOHYDROLASE (OXG-RCBH)
Descriptor:oligoxyloglucan reducing-end-specific cellobiohydrolase
Authors:Yaoi, K., Kondo, H., Noro, N., Suzuki, M., Tsuda, S., Mitsuishi, Y.
Deposit date:2004-03-19
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tandem Repeat of a Seven-Bladed beta-Propeller Domain in Oligoxyloglucan Reducing-End-Specific Cellobiohydrolase
Structure, 12, 2004
1V5C
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THE CRYSTAL STRUCTURE OF THE INACTIVE FORM CHITOSANASE FROM BACILLUS SP. K17 AT PH3.7
Descriptor:chitosanase, SULFATE ION
Authors:Adachi, W., Shimizu, S., Sunami, T., Fukazawa, T., Suzuki, M., Yatsunami, R., Nakamura, S., Takenaka, A.
Deposit date:2003-11-22
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of family GH-8 chitosanase with subclass II specificity from Bacillus sp. K17
J.MOL.BIOL., 343, 2004
1V5D
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THE CRYSTAL STRUCTURE OF THE ACTIVE FORM CHITOSANASE FROM BACILLUS SP. K17 AT PH6.4
Descriptor:chitosanase, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
Authors:Adachi, W., Shimizu, S., Sunami, T., Fukazawa, T., Suzuki, M., Yatsunami, R., Nakamura, S., Takenaka, A.
Deposit date:2003-11-22
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of family GH-8 chitosanase with subclass II specificity from Bacillus sp. K17
J.MOL.BIOL., 343, 2004
1GCC
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SOLUTION NMR STRUCTURE OF THE COMPLEX OF GCC-BOX BINDING DOMAIN OF ATERF1 AND GCC-BOX DNA, MINIMIZED AVERAGE STRUCTURE
Descriptor:DNA (5'-D(*TP*AP*GP*CP*CP*GP*CP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*GP*CP*GP*GP*CP*TP*A)-3'), ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 1
Authors:Yamasaki, K., Allen, M.D., Ohme-Takagi, M., Tateno, M., Suzuki, M.
Deposit date:1998-03-13
Release date:1999-03-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA.
EMBO J., 17, 1998
2GCC
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SOLUTION STRUCTURE OF THE GCC-BOX BINDING DOMAIN, NMR, MINIMIZED MEAN STRUCTURE
Descriptor:ATERF1
Authors:Allen, M.D., Yamasaki, K., Ohme-Takagi, M., Tateno, M., Suzuki, M.
Deposit date:1998-03-13
Release date:1999-03-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA.
EMBO J., 17, 1998
2Z4P
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CRYSTAL STRUCTURE OF FFRP-DM1
Descriptor:75aa long hypothetical regulatory protein AsnC, ISOLEUCINE
Authors:Yamada, M., Koike, H., Kudo, N., Suzuki, M.
Deposit date:2007-06-21
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Structural Code for Discriminating between Transcription Signals Revealed by the Feast/Famine Regulatory Protein DM1 in Complex with Ligands
Structure, 15, 2007
2Z5P
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APO-FR WITH LOW CONTENT OF PD IONS
Descriptor:Ferritin light chain, PALLADIUM ION, CADMIUM ION, ...
Authors:Ueno, T., Hirata, K., Abe, M., Suzuki, M., Abe, S., Shimizu, N., Yamamoto, M., Takata, M., Watanabe, Y.
Deposit date:2007-07-16
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Process of accumulation of metal ions on the interior surface of apo-ferritin: crystal structures of a series of apo-ferritins containing variable quantities of Pd(II) ions.
J.Am.Chem.Soc., 131, 2009
2Z5Q
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APO-FR WITH INTERMEDIATE CONTENT OF PD ION
Descriptor:Ferritin light chain, PALLADIUM ION, CADMIUM ION, ...
Authors:Ueno, T., Hirata, K., Abe, M., Suzuki, M., Abe, S., Shimizu, N., Yamamoto, M., Takata, M., Watanabe, Y.
Deposit date:2007-07-16
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Process of accumulation of metal ions on the interior surface of apo-ferritin: crystal structures of a series of apo-ferritins containing variable quantities of Pd(II) ions.
J.Am.Chem.Soc., 131, 2009
2Z5R
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APO-FR WITH HIGH CONTENT OF PD IONS
Descriptor:Ferritin light chain, PALLADIUM ION, CADMIUM ION
Authors:Ueno, T., Hirata, K., Abe, M., Suzuki, M., Abe, S., Shimizu, N., Yamamoto, M., Takata, M., Watanabe, Y.
Deposit date:2007-07-16
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Process of accumulation of metal ions on the interior surface of apo-ferritin: crystal structures of a series of apo-ferritins containing variable quantities of Pd(II) ions.
J.Am.Chem.Soc., 131, 2009
3ASX
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 1-{4-[{4-CHLORO-2-[(2-CHLOROPHENYL)(HYDROXY)METHYL]PHENYL}(2,2-DIMETHYLPROPYL)AMINO]-4-OXOBUTANOYL}PIPERIDINE-3-CARBOXYLIC ACID
Descriptor:Squalene synthase, PHOSPHATE ION, (3R)-1-{4-[{4-chloro-2-[(S)-(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid
Authors:Shimizu, H., Suzuki, M., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.
Deposit date:2010-12-22
Release date:2011-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
Bioorg.Med.Chem., 19, 2011
3FI6
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APO-H49AFR WITH HIGH CONTENT OF PD IONS
Descriptor:Ferritin light chain, PALLADIUM ION, CADMIUM ION, ...
Authors:Abe, M., Ueno, T., Hirata, K., Suzuki, M., Abe, S., Shimizu, N., Yamaoto, M., Takata, M., Watanabe, Y.
Deposit date:2008-12-11
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Process of Accumulation of Metal Ions on the Interior Surface of apo-Ferritin: Crystal Structures of a Series of apo-Ferritins Containing Variable Quantities of Pd(II) Ions
J.Am.Chem.Soc., 131, 2009