Author results

4PZZ
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SECOND-SITE SCREENING OF K-RAS IN THE PRESENCE OF COVALENTLY ATTACHED FIRST-SITE LIGANDS
Descriptor:K-Ras, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Friberg, A., Camper, D.V., Olejniczak, E.T., Fesik, S.W.
Deposit date:2014-03-31
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.403 Å)
Cite:A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
J.Biomol.Nmr, 60, 2014
4Q01
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SECOND-SITE SCREENING OF K-RAS IN THE PRESENCE OF COVALENTLY ATTACHED FIRST-SITE LIGANDS
Descriptor:K-Ras, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Friberg, A., Camper, D.V., Olejniczak, E.T., Fesik, S.W.
Deposit date:2014-03-31
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.291 Å)
Cite:A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
J.Biomol.Nmr, 60, 2014
4Q02
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SECOND-SITE SCREENING OF K-RAS IN THE PRESENCE OF COVALENTLY ATTACHED FIRST-SITE LIGANDS
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Friberg, A., Camper, D.V., Olejniczak, E.T., Fesik, S.W.
Deposit date:2014-03-31
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
J.Biomol.Nmr, 60, 2014
4Q03
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SECOND-SITE SCREENING OF K-RAS IN THE PRESENCE OF COVALENTLY ATTACHED FIRST-SITE LIGANDS
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Friberg, A., Camper, D.V., Olejniczak, E.T., Fesik, S.W.
Deposit date:2014-03-31
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.201 Å)
Cite:A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
J.Biomol.Nmr, 60, 2014
5YRO
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RANL182A IN COMPLEX WITH RANBP1-CRM1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1,Exportin-1, ...
Authors:Sun, Q., Zhang, Y.
Deposit date:2017-11-09
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:RanL182A in complex with RanBP1-CRM1
To Be Published
5YST
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RANM189D IN COMPLEX WITH RANBP1-CRM1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1,Exportin-1, ...
Authors:Sun, Q., Zhang, Y.
Deposit date:2017-11-15
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:RanM189D in complex with RanBP1-CRM1
To Be Published
5YSU
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PLUMBAGIN IN COMPLEX WITH CRM1-RANM189D-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1,Exportin-1, ...
Authors:Sun, Q., Zhang, Y.
Deposit date:2017-11-15
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RanL182A in complex with RanBP1-CRM1
To Be Published
5YTB
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RANY197A IN COMPLEX WITH RANBP1-CRM1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1,Exportin-1, ...
Authors:Sun, Q., Zhang, Y.
Deposit date:2017-11-17
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RanY197A in complex with RanBP1-CRM1
To Be Published
4Y7R
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CRYSTAL STRUCTURE OF WDR5 IN COMPLEX WITH MYC MBIIIB PEPTIDE
Descriptor:WD repeat-containing protein 5, MYC MbIIIb peptide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Sun, Q., Phan, J., Olejniczak, E.T., Thomas, L.R., Fesik, S.W., Tansey, W.P.
Deposit date:2015-02-16
Release date:2015-04-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC.
Mol.Cell, 58, 2015
3HC7
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CRYSTAL STRUCTURE OF LYSIN B FROM MYCOBACTERIOPHAGE D29
Descriptor:Gene 12 protein
Authors:Sun, Q., Sacchettini, J.C.
Deposit date:2009-05-05
Release date:2009-07-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase
Mol.Microbiol., 73, 2009
4GIW
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CRYSTAL STRUCTURE OF THE RUN DOMAIN OF HUMAN NESCA
Descriptor:RUN and SH3 domain-containing protein 1
Authors:Bai, L., Sun, Q., Jiang, T.
Deposit date:2012-08-09
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and functional implication of the RUN domain of human NESCA
Protein Cell, 3, 2012
4GMX
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CRYSTAL STRUCTURE OF KPT185 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-08-16
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Blood, 120, 2012
4GPT
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CRYSTAL STRUCTURE OF KPT251 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-08-21
Release date:2012-09-05
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Leukemia, 27, 2013
4WVF
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CRYSTAL STRUCTURE OF KPT276 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Crm1p, ...
Authors:Sun, Q., Chook, Y.
Deposit date:2014-11-05
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat.Neurosci., 18, 2015
5WFO
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LIGAND-BOUND RAS:SOS:RAS COMPLEX
Descriptor:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Burns, M.C., Fesik, S.W.
Deposit date:2017-07-12
Release date:2018-05-23
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
5WFP
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LIGAND-BOUND RAS:SOS:RAS COMPLEX
Descriptor:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Burns, M.C., Fesik, S.W.
Deposit date:2017-07-12
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
5WFQ
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LIGAND-BOUND RAS:SOS:RAS COMPLEX
Descriptor:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Burns, M.C., Fesik, S.W.
Deposit date:2017-07-12
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
5WFR
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LIGAND-BOUND RAS:SOS:RAS COMPLEX
Descriptor:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
Authors:Sun, Q., Phan, J., Burns, M.C., Fesik, S.W.
Deposit date:2017-07-12
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
5WYJ
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CRYO-EM STRUCTURE OF THE 90S SMALL SUBUNIT PRE-RIBOSOME (DHR1-DEPLETED, ENP1-TAP, STATE 1)
Descriptor:U3 RNA, rRNA 2'-O-methyltransferase fibrillarin, Nucleolar protein 56, ...
Authors:Ye, K., Zhu, X., Sun, Q.
Deposit date:2017-01-13
Release date:2017-03-29
Last modified:2017-05-17
Method:ELECTRON MICROSCOPY (8.7 Å)
Cite:Molecular architecture of the 90S small subunit pre-ribosome.
Elife, 6, 2017
5WYK
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CRYO-EM STRUCTURE OF THE 90S SMALL SUBUNIT PRE-RIBOSOME (MTR4-DEPLETED, ENP1-TAP)
Descriptor:U3 RNA, rRNA 2'-O-methyltransferase fibrillarin, Nucleolar protein 56, ...
Authors:Ye, K., Zhu, X., Sun, Q.
Deposit date:2017-01-13
Release date:2017-03-29
Last modified:2017-05-17
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Molecular architecture of the 90S small subunit pre-ribosome.
Elife, 6, 2017
5WYH
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CRYSTAL STRUCTURE OF RIDL(1-200) COMPLEXED WITH VPS29
Descriptor:Vacuolar protein sorting-associated protein 29, Interaptin, GLYCEROL
Authors:Yao, J., Sun, Q., Jia, D.
Deposit date:2017-01-13
Release date:2018-01-24
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Mechanism of inhibition of retromer transport by the bacterial effector RidL.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1R0E
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GLYCOGEN SYNTHASE KINASE-3 BETA IN COMPLEX WITH 3-INDOLYL-4-ARYLMALEIMIDE INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, CITRATE ANION, 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE
Authors:Allard, J., Nikolcheva, T., Gong, L., Wang, J., Dunten, P., Avnur, Z., Waters, R., Sun, Q., Skinner, B.
Deposit date:2003-09-20
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:From genetics to therapeutics: the Wnt pathway and osteoporosis
To be Published
3BUM
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SPROUTY2
Descriptor:Portein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, A.R., Buschdorf, P.J., Sun, Q., Guy, R.G., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUN
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SPROUTY4
Descriptor:13-meric peptide from Portein sprouty homolog 4, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUO
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN EGF RECEPTOR'
Descriptor:13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008