Author results

3UH0
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CRYSTAL STRUCTURE OF THE YEAST MITOCHONDRIAL THREONYL-TRNA SYNTHETASE (MST1) IN COMPLEX WITH THREONYL SULFAMOYL ADENYLATE
Descriptor:Threonyl-tRNA synthetase, mitochondrial, ZINC ION, ...
Authors:Peterson, K.M., Ling, J., Simonovic, I., Cho, C., Soll, D., Simonovic, M.
Deposit date:2011-11-03
Release date:2012-02-22
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment.
Proc.Natl.Acad.Sci.USA, 109, 2012
4DWQ
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RNA LIGASE RTCB-GMP/MN(2+) COMPLEX
Descriptor:tRNA-splicing ligase RtcB, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ...
Authors:Okada, C., Xia, S., Englert, M., Yao, M., Soll, D., Wang, J.
Deposit date:2012-02-26
Release date:2012-09-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.
Proc.Natl.Acad.Sci.USA, 109, 2012
4DWR
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RNA LIGASE RTCB/MN2+ COMPLEX
Descriptor:tRNA-splicing ligase RtcB, SUCROSE, MANGANESE (II) ION, ...
Authors:Xia, S., Englert, M., Soll, D., Wang, J.
Deposit date:2012-02-26
Release date:2012-09-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.
Proc.Natl.Acad.Sci.USA, 109, 2012
4EO4
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CRYSTAL STRUCTURE OF THE YEAST MITOCHONDRIAL THREONYL-TRNA SYNTHETASE (MST1) IN COMPLEX WITH SERYL SULFAMOYL ADENYLATE
Descriptor:Threonine--tRNA ligase, mitochondrial, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, ...
Authors:Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M.
Deposit date:2012-04-13
Release date:2012-07-11
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:The mechanism of pre-transfer editing in yeast mitochondrial threonyl-tRNA synthetase.
J.Biol.Chem., 287, 2012
4Y4O
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO PROTEIN Y (YFIA) AT 2.3A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4Y4P
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.5A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
5J4B
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (CO-CRYSTALLIZED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5J4C
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (SOAKED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5UD5
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CRYSTAL STRUCTURE OF THE TRNA BINDING DOMAIN OF PYRROLYSYL-TRNA SYNTHETASE BOUND TO TRNA(PYL)
Descriptor:Pyrrolysine--tRNA ligase, RNA (70-MER), ZINC ION
Authors:Suzuki, T., Soll, D.
Deposit date:2016-12-23
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.347 Å)
Cite:Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.
Nat. Chem. Biol., 13, 2017
5V6X
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CRYSTAL STRUCTURE OF THE TRNA BINDING DOMAIN OF PYRROLYSYL-TRNA SYNTHETASE MUTANT (32A NTD) BOUND TO TRNA(PYL)
Descriptor:Pyrrolysine--tRNA ligase, RNA (70-MER), ZINC ION
Authors:Suzuki, T., Soll, D.
Deposit date:2017-03-17
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.
Nat. Chem. Biol., 13, 2017
6N9E
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC CC-PMN AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
Authors:Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 2018
6N9F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC ACCA-DPHE AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
Authors:Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 2018
1QRS
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GLUTAMINYL-TRNA SYNTHETASE MUTANT D235N COMPLEXED WITH GLUTAMINE TRANSFER RNA
Descriptor:TRNAGLN2, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE (E.C.6.1.1.18)), ADENOSINE-5'-TRIPHOSPHATE
Authors:Arnez, J.G., Steitz, T.A.
Deposit date:1996-06-14
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP.
Biochemistry, 35, 1996
1QRT
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GLUTAMINYL-TRNA SYNTHETASE MUTANT D235G COMPLEXED WITH GLUTAMINE TRANSFER RNA
Descriptor:TRNAGLN2, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE (E.C.6.1.1.18)), ADENOSINE-5'-TRIPHOSPHATE
Authors:Arnez, J.G., Steitz, T.A.
Deposit date:1996-06-14
Release date:1996-12-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP.
Biochemistry, 35, 1996
1QRU
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GLUTAMINYL-TRNA SYNTHETASE MUTANT I129T COMPLEXED WITH GLUTAMINE TRANSFER RNA
Descriptor:TRNAGLN2, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE (E.C.6.1.1.18)), ADENOSINE-5'-TRIPHOSPHATE
Authors:Arnez, J.G., Steitz, T.A.
Deposit date:1996-06-14
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP.
Biochemistry, 35, 1996
1GSG
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STRUCTURE OF E.COLI GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNAGLN AND ATP AT 2.8 ANGSTROMS RESOLUTION
Descriptor:TRNAGLN, GLUTAMINYL-TRNA SYNTHETASE
Authors:Rould, M.A., Perona, J.J., Soell, D., Steitz, T.A.
Deposit date:1990-04-03
Release date:1992-02-24
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution.
Science, 246, 1989
4Q6G
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF ACKRS-1 BOUND WITH N-ACETYL-LYSINE AND ADPNP
Descriptor:Pyrrolysine--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1,2-ETHANEDIOL, ...
Authors:Eiler, D.R., Kavran, J., Steitz, T.A.
Deposit date:2014-04-22
Release date:2014-11-12
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Proc.Natl.Acad.Sci.USA, 111, 2014
2D6F
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CRYSTAL STRUCTURE OF GLU-TRNA(GLN) AMIDOTRANSFERASE IN THE COMPLEX WITH TRNA(GLN)
Descriptor:tRNA, Glutamyl-tRNA(Gln) amidotransferase subunit D, Glutamyl-tRNA(Gln) amidotransferase subunit E, ...
Authors:Nureki, O.
Deposit date:2005-11-13
Release date:2006-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis of RNA-dependent recruitment of glutamine to the genetic code
Science, 312, 2006
2ODR
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METHANOCOCCUS MARIPALUDIS PHOSPHOSERYL-TRNA SYNTHETASE
Descriptor:phosphoseryl-tRNA synthetase
Authors:Steitz, T.A., Kamtekar, S.
Deposit date:2006-12-26
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.228 Å)
Cite:Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q7E
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THE STRUCTURE OF PYRROLYSYL-TRNA SYNTHETASE BOUND TO AN ATP ANALOGUE
Descriptor:Pyrrolysyl-tRNA synthetase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Kavran, J.M., Steitz, T.A.
Deposit date:2007-06-06
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q7G
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PYRROLYSINE TRNA SYNTHETASE BOUND TO A PYRROLYSINE ANALOGUE (CYC) AND ATP
Descriptor:Pyrrolysyl-tRNA synthetase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Kavran, J.M., Steitz, T.A.
Deposit date:2007-06-06
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q7H
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PYRROLYSYL-TRNA SYNTHETASE BOUND TO ADENYLATED PYRROLYSINE AND PYROPHOSPHATE
Descriptor:Pyrrolysyl-tRNA synthetase, 1,2-ETHANEDIOL, (2R)-2-AMINO-6-({[(2S,3R)-3-METHYLPYRROLIDIN-2-YL]CARBONYL}AMINO)HEXANOYL [(2S,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL HYDROGEN (R)-PHOSPHATE, ...
Authors:Kavran, J.M., Steitz, T.A.
Deposit date:2007-06-06
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2ZIM
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PYRROLYSYL-TRNA SYNTHETASE BOUND TO ADENYLATED PYRROLYSINE AND PYROPHOSPHATE
Descriptor:Pyrrolysyl-tRNA synthetase, 1,2-ETHANEDIOL, (2R)-2-AMINO-6-({[(2S,3R)-3-METHYLPYRROLIDIN-2-YL]CARBONYL}AMINO)HEXANOYL [(2S,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL HYDROGEN (R)-PHOSPHATE, ...
Authors:Steitz, T.A., Kavran, J.M.
Deposit date:2008-02-19
Release date:2008-03-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3AII
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ARCHAEAL NON-DISCRIMINATING GLUTAMYL-TRNA SYNTHETASE FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS
Descriptor:Glutamyl-tRNA synthetase, ACETIC ACID, 1,2-ETHANEDIOL, ...
Authors:Nureki, O., Ishitani, R.
Deposit date:2010-05-14
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation
Nucleic Acids Res., 2010
3AM1
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CRYSTAL STRUCTURE OF O-PHOSPHOSERYL-TRNA KINASE COMPLEXED WITH ANTICODON-STEM/LOOP TRUNCATED TRNA(SEC)
Descriptor:L-seryl-tRNA(Sec) kinase, ASL-truncated tRNA, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Araiso, Y., Ishitani, R., Nureki, O.
Deposit date:2010-08-11
Release date:2010-12-29
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:C-terminal domain of archaeal O-phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNA(Sec)
Nucleic Acids Res., 39, 2011
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