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8AYG
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BU of 8ayg by Molmil
Crystal structure of an intramolecular i-motif at the insulin-linked polymorphic region (ILPR)
Descriptor: Insulin-linked polymorphic region, ILPR DNA (31-MER)
Authors:Parkinson, G.N, Alexandrou, E, Waller, Z.A.E, El-Omari, K.
Deposit date:2022-09-02
Release date:2023-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of an intramolecular i-motif at the insulin-linked polymorphic region (ILPR)
To Be Published
1K8P
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BU of 1k8p by Molmil
Structure of the Human G-quadruplex reveals a novel topology
Descriptor: 5'-D(*(BRU)P*AP*GP*GP*GP*(BRU)P*TP*AP*GP*GP*GP*T)-3', POTASSIUM ION, SODIUM ION
Authors:Parkinson, G.N, Lee, M.P.H, Neidle, S.
Deposit date:2001-10-25
Release date:2002-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of parallel quadruplexes from human telomeric DNA.
Nature, 417, 2002
1KF1
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BU of 1kf1 by Molmil
Structure and Packing of Human Telomeric DNA
Descriptor: 5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3, POTASSIUM ION
Authors:Parkinson, G.N, Lee, M.P.H, Neidle, S.
Deposit date:2001-11-19
Release date:2002-05-31
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of parallel quadruplexes from human telomeric DNA.
Nature, 417, 2002
210D
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BU of 210d by Molmil
CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A)CG] AND ITS PLATINATED DERIVATIVE
Descriptor: DNA (5'-D(*CP*GP*TP*(1AP)P*CP*G)-3'), SPERMINE
Authors:Parkinson, G.N, Arvantis, G.M, Lessinger, L, Ginell, S.L, Jones, R, Gaffney, B, Berman, H.M.
Deposit date:1995-06-13
Release date:1996-03-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.
Biochemistry, 34, 1995
211D
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BU of 211d by Molmil
THE CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A) CG] AND ITS PLATINATED DERIVATIVE
Descriptor: DNA (5'-D(*CP*GP*TP*(1AP)P*CP*(PT(NH3)3)G)-3'), PLATINUM TRIAMINE ION, SPERMINE
Authors:Parkinson, G.N, Arvantis, G.M, Lessinger, L, Ginell, S.L, Jones, R, Gaffney, B, Berman, H.M.
Deposit date:1995-06-13
Release date:1996-03-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.
Biochemistry, 34, 1995
2AR5
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BU of 2ar5 by Molmil
Crystal structure of the mammalian C2alpha-PI3 Kinase PX-domain
Descriptor: GLYCEROL, Phosphoinositide 3-kinase
Authors:Parkinson, G.N, Vines, D, Driscoll, P.C, Djordjevic, S.
Deposit date:2005-08-19
Release date:2006-10-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand-binding specificity of PI3Kinase C2alpha PX domain.
To be Published
2HRI
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BU of 2hri by Molmil
A parallel stranded human telomeric quadruplex in complex with the porphyrin TMPyP4
Descriptor: (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3', POTASSIUM ION
Authors:Parkinson, G.N, Ghosh, R, Neidle, S.
Deposit date:2006-07-20
Release date:2007-05-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural basis for binding of porphyrin to human telomeres.
Biochemistry, 46, 2007
3CDM
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BU of 3cdm by Molmil
Structural adaptation and conservation in quadruplex-drug recognition
Descriptor: 2,7-bis[3-(dimethylamino)propyl]-4,9-bis[(3-hydroxypropyl)amino]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, DNA (5'-D(*DT*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DG)-3'), POTASSIUM ION
Authors:Parkinson, G.N, Neidle, S.
Deposit date:2008-02-27
Release date:2008-09-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
J.Mol.Biol., 381, 2008
3CCO
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BU of 3cco by Molmil
Structural adaptation and conservation in quadruplex-drug recognition
Descriptor: 2,7-bis[3-(dimethylamino)propyl]-4,9-bis[(3-hydroxypropyl)amino]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, DNA (5'-D(*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DT)-3'), POTASSIUM ION, ...
Authors:Parkinson, G.N, Neidle, S.
Deposit date:2008-02-26
Release date:2008-09-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
J.Mol.Biol., 381, 2008
2REA
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BU of 2rea by Molmil
Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
Descriptor: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
Authors:Parkinson, G.N, Vines, D, Driscoll, P.C, Djordjevic, S.
Deposit date:2007-09-26
Release date:2007-11-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
Bmc Struct.Biol., 8, 2008
2RED
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BU of 2red by Molmil
Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
Descriptor: GLYCEROL, Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
Authors:Parkinson, G.N, Vines, D, Driscoll, P.C, Djordjevic, S.
Deposit date:2007-09-26
Release date:2007-11-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
Bmc Struct.Biol., 8, 2008
6GDS
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BU of 6gds by Molmil
Holliday Junctions formed from Telomeric DNA
Descriptor: Telomeric DNA (5' CTAACCCTAA) 10mer, Telomeric DNA (5'-TTAGGGTTAG)-3') 10mer
Authors:Parkinson, G.N, Haider, S, Li, P, Khiali, S, Munnur, D, Ramanathan, A.
Deposit date:2018-04-24
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Holliday Junctions Formed from Human Telomeric DNA.
J. Am. Chem. Soc., 140, 2018
6GDN
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BU of 6gdn by Molmil
Holliday Junctions formed from Telomeric DNA
Descriptor: MAGNESIUM ION, Telomere DNA (42-MER)
Authors:Parkinson, G.N, Haider, S, Li, P, Khiali, S, Munnur, D, Ramanathan, A.
Deposit date:2018-04-24
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Holliday Junctions Formed from Human Telomeric DNA.
J. Am. Chem. Soc., 140, 2018
6GDH
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BU of 6gdh by Molmil
Holliday Junctions formed from Telomeric DNA
Descriptor: DNA (5'-D(*CP*TP*AP*AP*CP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3')
Authors:Parkinson, G.N, Haider, S, Li, P, Khiali, S, Munnur, D, Ramanathan, A.
Deposit date:2018-04-23
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Holliday Junctions Formed from Human Telomeric DNA.
J. Am. Chem. Soc., 140, 2018
6HPS
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BU of 6hps by Molmil
Near-infrared dual bioluminescence imaging in vivo using infra-luciferin
Descriptor: Luciferin 4-monooxygenase, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[[2-[(~{E})-2-(6-oxidanyl-1,3-benzothiazol-2-yl)ethenyl]-1,3-thiazol-4-yl]carbonyl]sulfamate
Authors:Parkinson, G.N, Stowe, C, Anderson, J.C.
Deposit date:2018-09-21
Release date:2019-10-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin.
Elife, 8, 2019
5DWX
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BU of 5dwx by Molmil
Structural Insights into the Quadruplex-Duplex 3' Interface formed from a Telomeric Repeat - TLOOP
Descriptor: DNA (24-MER), DNA complementary strand, POTASSIUM ION
Authors:Parkinson, G.N, Russo Krauss, I.
Deposit date:2015-09-23
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.
J.Am.Chem.Soc., 138, 2016
6TQI
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BU of 6tqi by Molmil
I-MOTIF STRUCTURE FORMED FROM THE C STRAND OF A HUMAN TELOMERE FRAGMENT
Descriptor: DNA (5'-*TP*AP*AP*CP*CP*CP*TP*AP*A-3')
Authors:Parkinson, G.N, Wagner, A, Viladoms-Claverol, J, Duman, R, El-Omari, K.
Deposit date:2019-12-16
Release date:2020-06-10
Last modified:2020-11-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.
Nucleic Acids Res., 48, 2020
4WO2
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BU of 4wo2 by Molmil
CRYSTAL STRUCTURE OF HUMAN NATIVE CKIT PROTO-ONCOGENE PROMOTER QUADRUPLEX DNA
Descriptor: DNA (5'-D(*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*CP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*G)-3'), POTASSIUM ION
Authors:wei, D, parkinson, g.n, neidle, s.
Deposit date:2014-10-15
Release date:2014-10-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:CRYSTAL STRUCTURE OF HUMAN NATIVE CKIT-1 PROTO-ONCOGENE PROMOTER QUADRUPLEX DNA
TO BE PUBLISHED
6JJH
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BU of 6jjh by Molmil
Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4
Descriptor: (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, POTASSIUM ION, RNA (5'-R(*GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3')
Authors:Zhang, Y.S, EI Omari, K, Duman, R, Wagner, A, Parkinson, G.N, Wei, D.G.
Deposit date:2019-02-25
Release date:2020-02-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.
Nucleic Acids Res., 48, 2020
6JJF
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BU of 6jjf by Molmil
Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex
Descriptor: COBALT HEXAMMINE(III), DNA (5'-D(*GP*GP*CP*TP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3'), POTASSIUM ION, ...
Authors:Zhang, Y.S, EI Omari, K, Duman, R, Wagner, A, Parkinson, G.N, Wei, D.G.
Deposit date:2019-02-25
Release date:2020-02-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.
Nucleic Acids Res., 48, 2020
6KFL
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BU of 6kfl by Molmil
Crystal structure of a two-quartet DNA G-quadruplex complexed with the porphyrin TMPyP4
Descriptor: (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, COBALT HEXAMMINE(III), DNA (5'-D(*GP*GP*CP*TP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3'), ...
Authors:Zhang, Y.S, Parkinson, G.N, Wei, D.G.
Deposit date:2019-07-08
Release date:2020-07-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of a two-quartet DNA G-quadruplex complexed with the porphyrin TMPyP4
To Be Published
6JJI
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BU of 6jji by Molmil
Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4 (1:1)
Descriptor: (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, POTASSIUM ION, RNA (5'-R(*GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3')
Authors:Zhang, Y.S, Parkinson, G.N, Wei, D.G.
Deposit date:2019-02-25
Release date:2020-02-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.
Nucleic Acids Res., 48, 2020
6XRQ
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BU of 6xrq by Molmil
Structural descriptions of ligand interactions to DNA and RNA quadruplexes folded from the non-coding region of Pseudorabies virus
Descriptor: 2,7-bis[3-(morpholin-4-yl)propyl]-4,9-bis{[3-(morpholin-4-yl)propyl]amino}benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, POTASSIUM ION, RNA (5' GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A-3')
Authors:Zhang, Y.S, Parkinson, G.N, Wei, D.G.
Deposit date:2020-07-13
Release date:2021-07-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Structural descriptions of ligand interactions to DNA and RNA quadruplexes folded from the non-coding region of Pseudorabies virus
To Be Published
5DWW
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BU of 5dww by Molmil
Structural Insights into the Quadruplex-Duplex 3' Interface formed from a Telomeric Repeat - TTLOOP
Descriptor: DNA (25-MER), DNA (5'-D(*TP*AP*AP*CP*GP*CP*TP*A)-3'), POTASSIUM ION
Authors:Russo Krauss, I, Parkinson, G.N.
Deposit date:2015-09-23
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.
J.Am.Chem.Soc., 138, 2016
4E68
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BU of 4e68 by Molmil
Unphosphorylated STAT3B core protein binding to dsDNA
Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3
Authors:Collie, G.W, Parkinson, G.N, Shah, R.
Deposit date:2012-03-15
Release date:2013-03-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.585 Å)
Cite:Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.
Febs Lett., 587, 2013

 

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