Author results

3EY3
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A CONFORMATIONAL TRANSITION IN THE STRUCTURE OF A 2'-THIOMETHYL-MODIFIED DNA VISUALIZED AT HIGH RESOLUTION
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*(USM)P*CP*GP*CP*G)-3', STRONTIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Egli, M., Pallan, P.S.
Deposit date:2008-10-17
Release date:2009-04-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
3I8D
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THE PAIRING GEOMETRY OF THE HYDROPHOBIC THYMINE ANALOG 2,4-DIFLUOROTOLUENE IN DUPLEX DNA AS ANALYZED BY X-RAY CRYSTALLOGRAPHY
Descriptor:Ribonuclease H, 5'-D(*CP*GP*CP*GP*AP*AP*TP*(DFT)P*CP*GP*CP*G)-3', GLYCEROL
Authors:Egli, M., Pallan, P.S.
Deposit date:2009-07-09
Release date:2009-09-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Pairing geometry of the hydrophobic thymine analogue 2,4-difluorotoluene in duplex DNA as analyzed by X-ray crystallography.
J.Am.Chem.Soc., 131, 2009
3P4A
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2'FLUORO MODIFIED RNA OCTAMER FA2U2
Descriptor:2'Fluoro modified RNA 8-MER, STRONTIUM ION, MAGNESIUM ION
Authors:Manoharan, M., Akinc, A., Pandey, R.K., Qin, J., Hadwiger, P., John, M., Mills, K., Charisse, K., Maier, M.A., Nechev, L., Greene, E.M., Pallan, P.S., Rozners, E., Rajeev, K.G., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
4DKZ
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HAIRPIN STRUCTURE OF A DNA DODECAMER CONTAINING NORTH-METHANOCARBA-2'-DEOXYTHYMIDINE
Descriptor:Synthetic DNA dodecamer containg North-methanocarba-2'-deoxythymidine (N-MCdT)
Authors:Egli, M., Pallan, P.S.
Deposit date:2012-02-05
Release date:2012-03-28
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Conformationally Constrained N-Methanocarba-dT Analogue Adopts an Unexpected C4'-exo Sugar Pucker in the Structure of a DNA Hairpin.
Biochemistry, 51, 2012
4F2X
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STRUCTURE OF 3'-FLUORO CYCLOHEXENYL NUCLEIC ACID HEPTAMER
Descriptor:5'-D(*GP*CP*GP*(XTF)P*GP*CP*G)-3', 5'-D(*CP*GP*CP*AP*CP*GP*C)-3', COBALT HEXAMMINE(III), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2012-05-08
Release date:2012-05-30
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2'-Fluoro RNA.
J.Org.Chem., 77, 2012
4F2Y
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STRUCTURE OF 3'-FLUORO CYCLOHEXENYL NUCLEIC ACID DECAMER
Descriptor:5'-D(*GP*CP*GP*TP*AP*(XTF)P*AP*CP*GP*C)-3', MAGNESIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2012-05-08
Release date:2012-05-30
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2'-Fluoro RNA.
J.Org.Chem., 77, 2012
4O41
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AMIDE LINKED RNA
Descriptor:AMIDE LINKED RNA, STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2013-12-18
Release date:2014-07-09
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Nucleic Acids Res., 42, 2014
4OPJ
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BH-RNASEH:TCDA-DNA COMPLEX
Descriptor:5'-D(*CP*GP*CP*GP*AP*(TCY)P*TP*TP*CP*GP*CP*G)-3', Ribonuclease H, GLYCEROL
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-02-05
Release date:2015-02-11
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.541 Å)
Cite:Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes.
Methods Mol.Biol., 1320
4OPK
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BH-RNASEH:2'-SME-DNA COMPLEX
Descriptor:Ribonuclease H, 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*TP*CP*GP*CP*G)-3', GLYCEROL
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-02-05
Release date:2015-02-11
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.539 Å)
Cite:Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes.
Methods Mol.Biol., 1320
5DO4
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THROMBIN-RNA APTAMER COMPLEX
Descriptor:Thrombin light chain, Thrombin heavy chain, RNA (25-MER), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2015-09-10
Release date:2016-09-14
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
Nucleic Acids Res., 44, 2016
5V1K
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STRUCTURE OF R-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-21
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
5V1L
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STRUCTURE OF S-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), STRONTIUM ION, SPERMINE
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-14
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5VAJ
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BHRNASE H - AMIDE-RNA/DNA COMPLEX
Descriptor:RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*(URU)P*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), Ribonuclease H, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-27
Release date:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
Nucleic Acids Res., 45, 2017
5VBU
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 21A2 HYDROXYPROGESTERONE COMPLEX
Descriptor:Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (9beta)-17-hydroxypregn-4-ene-3,20-dione
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-30
Release date:2017-05-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.
J. Biol. Chem., 292, 2017
5W1Z
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CRYSTAL STRUCTURE OF INOSINE-SUBSTITUTED DECAMER DUPLEX DNA (I4)
Descriptor:DNA (5'-D(*CP*CP*AP*IP*IP*CP*CP*(BRU)P*IP*I)-3'), MAGNESIUM ION, SODIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-06-05
Release date:2017-08-30
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.
J. Biomol. Struct. Dyn., 36, 2018
5W20
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CRYSTAL STRUCTURE OF INOSINE-SUBSTITUTED DUPLEX DNA
Descriptor:DNA (5'-D(*CP*CP*AP*IP*IP*CP*CP*TP*GP*G)-3'), MAGNESIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-06-05
Release date:2017-08-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.
J. Biomol. Struct. Dyn., 36, 2018
6B82
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ZEBRA FISH CYP-450 17A1 MUTANT ABIRATERONE COMPLEX
Descriptor:Cytochrome P450, family 17, subfamily A, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-10-05
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Inherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes.
J. Biol. Chem., 293, 2018
1WV5
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X-RAY STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-BUTYL THYMINE IN PLACE OF T6, MG-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2BT)P*AP*CP*GP*C)-3', MAGNESIUM ION
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharam, M.
Deposit date:2004-12-11
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry, 44, 2005
1WV6
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X-RAY STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-BUTYL THYMINE IN PLACE OF T6, SR-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2BT)P*AP*CP*GP*C)-3', STRONTIUM ION
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharam, M.
Deposit date:2004-12-11
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry, 44, 2005
1Y7F
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CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-[HYDROXY(METHYLENEAMINO)OXY]ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2NT)P*AP*CP*GP*C)-3'), BARIUM ION
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-08
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y84
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CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(IMIDAZOLYL)ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(EIT)P*AP*CP*GP*C)-3', MAGNESIUM ION, SPERMINE
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-10
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y86
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CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(FLUORO)ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3'
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-10
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y8L
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CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(TRIFLUORO)ETHYL] THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(TFE)P*AP*CP*GP*C)-3'), MAGNESIUM ION, SPERMINE
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-13
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y8V
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CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-PROPYL THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(P2T)P*AP*CP*GP*C)-3'
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-13
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005
1Y9F
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CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-ALLYL THYMIDINE (T*)
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2AT)P*AP*CP*GP*C)-3')
Authors:Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Deposit date:2004-12-15
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry, 44, 2005