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4KS0
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BU of 4ks0 by Molmil
Pyruvate kinase (PYK) from Trypanosoma cruzi in the presence of Magnesium, oxalate and F26BP
Descriptor: 2,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, OXALATE ION, ...
Authors:Morgan, H.P, Zhong, W, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2013-05-17
Release date:2014-11-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.
R Soc Open Sci, 1, 2014
3SRF
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BU of 3srf by Molmil
Human M1 pyruvate kinase
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRH
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BU of 3srh by Molmil
Human M2 pyruvate kinase
Descriptor: PHOSPHATE ION, Pyruvate kinase isozymes M1/M2
Authors:Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRD
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BU of 3srd by Molmil
Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and Oxalate.
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ...
Authors:Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRK
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BU of 3srk by Molmil
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
Descriptor: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, Pyruvate kinase, ...
Authors:Morgan, H.P, Walsh, M, Blackburn, E.A, Wear, M.A, Boxer, M, Shen, M, McNae, I.W, Michels, P.A.M, Auld, D.S, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-07-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
To be Published
3SW0
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BU of 3sw0 by Molmil
Structure of the C-terminal region (modules 18-20) of complement regulator Factor H
Descriptor: Complement factor H, GLYCEROL, PHOSPHATE ION
Authors:Morgan, H.P, Guariento, M, Schmidt, C.Q, Barlow, P.N, Hannan, J.P.
Deposit date:2011-07-13
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Analysis of the C-Terminal Region (Modules 18-20) of Complement Regulator Factor H (FH).
Plos One, 7, 2012
3HQO
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BU of 3hqo by Molmil
Crystal structures of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP and Oxalate
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, OXALATE ION, ...
Authors:Morgan, H.P, Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3HQN
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BU of 3hqn by Molmil
Apo crystal structure of Leishmania mexicana(LmPYK)pyruvate kinase
Descriptor: GLYCEROL, POTASSIUM ION, Pyruvate kinase, ...
Authors:Morgan, H.P, Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3HQQ
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BU of 3hqq by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with Fructose 2,6 bisphosphate
Descriptor: 2,6-di-O-phosphono-beta-D-fructofuranose, Pyruvate kinase
Authors:Morgan, H.P, Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (5.07 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3HQP
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BU of 3hqp by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP, Oxalate and fructose 2,6 bisphosphate
Descriptor: 2,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Morgan, H.P, Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3I2Z
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BU of 3i2z by Molmil
Structure of cold shock protein E from Salmonella typhimurium
Descriptor: RNA chaperone, negative regulator of cspA transcription
Authors:Morgan, H.P, McNae, I, Wear, M.A, Gallagher, M, Walkinshaw, M.D.
Deposit date:2009-06-30
Release date:2009-12-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium
Acta Crystallogr.,Sect.F, 65, 2009
3KTX
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BU of 3ktx by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK)in complex with 1,3,6,8-pyrenetetrasulfonic acid
Descriptor: GLYCEROL, Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid
Authors:Morgan, H.P, Walkinshaw, M.D.
Deposit date:2009-11-26
Release date:2010-02-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase.
Acta Crystallogr.,Sect.F, 66, 2010
3OXU
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BU of 3oxu by Molmil
Complement components factor H CCP19-20 and C3d in complex
Descriptor: Complement C3, GLYCEROL, HF protein
Authors:Morgan, H.P, Schmidt, C.Q, Guariento, M, Gillespie, D, Herbert, A.P, Mertens, H, Blaum, B.S, Svergun, D, Johansson, C.M, Uhrin, D, Barlow, P.N, Hannan, J.P.
Deposit date:2010-09-22
Release date:2011-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for engagement by complement factor H of C3b on a self surface.
Nat.Struct.Mol.Biol., 18, 2011
3PP7
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BU of 3pp7 by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase in complex with the drug suramin, an inhibitor of glycolysis.
Descriptor: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, GLYCEROL, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2010-11-24
Release date:2010-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV9
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BU of 3qv9 by Molmil
Crystal structure of Trypanosoma cruzi pyruvate kinase(TcPYK)in complex with ponceau S.
Descriptor: 3-hydroxy-4-[(E)-{2-sulfo-4-[(E)-(4-sulfophenyl)diazenyl]phenyl}diazenyl]naphthalene-2,7-disulfonic acid, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-07-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV7
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BU of 3qv7 by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with ponceau S and acid blue 25.
Descriptor: 3-hydroxy-4-[(E)-{2-sulfo-4-[(E)-(4-sulfophenyl)diazenyl]phenyl}diazenyl]naphthalene-2,7-disulfonic acid, 9,10-dioxo-4-(phenylamino)-9,10-dihydroanthracene-2-sulfonic acid, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV6
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BU of 3qv6 by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with acid blue 80.
Descriptor: 3-({4-[(2,4-dimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracen-1-yl}amino)-2,4,6-trimethylbenzenesulfonic acid, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV8
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BU of 3qv8 by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with benzothiazole-2,5-disulfonic acid.
Descriptor: 1,3-benzothiazole-2,5-disulfonic acid, PHOSPHATE ION, Pyruvate kinase
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3R62
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BU of 3r62 by Molmil
Structure of complement regulator Factor H mutant, T1184R.
Descriptor: Complement factor H, GLYCEROL
Authors:Morgan, H.P, Jiang, J, Herbert, A.P, Kavanagh, D, Uhran, D, Barlow, P.N, Hannan, J.P.
Deposit date:2011-03-21
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystallographic determination of the disease-associated T1184R variant of the complement Factor H.
Acta Crystallogr.,Sect.D, 67, 2011
3RJ3
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BU of 3rj3 by Molmil
Complement components factor H CCP19-20 (S1191L mutant) and C3D in complex
Descriptor: Complement C3d fragment, Complement Factor H-related protein 1, GLYCEROL
Authors:Morgan, H.P, Hannan, J.P.
Deposit date:2011-04-15
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and functional characterization of the product of disease-related factor h gene conversion.
Biochemistry, 51, 2012
3IS4
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BU of 3is4 by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK)in complex with 1,3,6,8-pyrenetetrasulfonic acid
Descriptor: GLYCEROL, Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid
Authors:Walkinshaw, M.D, Morgan, H.P.
Deposit date:2009-08-25
Release date:2010-03-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase
Acta Crystallogr.,Sect.F, 66, 2010
4FXF
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BU of 4fxf by Molmil
Structure of M2 pyruvate kinase in complex with phenylalanine
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Walkinshaw, M.D, Morgan, H.P.
Deposit date:2012-07-03
Release date:2013-03-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4FXJ
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BU of 4fxj by Molmil
Structure of M2 pyruvate kinase in complex with phenylalanine
Descriptor: PHENYLALANINE, PHOSPHATE ION, Pyruvate kinase isozymes M1/M2
Authors:Walkinshaw, M.D, Morgan, H.P.
Deposit date:2012-07-03
Release date:2013-03-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KRZ
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BU of 4krz by Molmil
Apo crystal structure of pyruvate kinase (PYK) from Trypanosoma cruzi
Descriptor: GLYCEROL, POTASSIUM ION, Pyruvate kinase
Authors:Zhong, W, Morgan, H.P, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2013-05-17
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.
R Soc Open Sci, 1, 2014
3IGY
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BU of 3igy by Molmil
Crystal structures of Leishmania mexicana phosphoglycerate mutase at high cobalt concentrations
Descriptor: 2-PHOSPHOGLYCERIC ACID, 3-PHOSPHOGLYCERIC ACID, COBALT (II) ION, ...
Authors:Nowicki, M.W, Kuaprasert, B, McNae, I.W, Morgan, H.P, Harding, M.M, Michels, P.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2009-07-29
Release date:2009-10-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
J.Mol.Biol., 394, 2009

 

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