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4RRY
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.429 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRZ
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RS0
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CRYSTAL STRUCTURE OF MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH S-IBUPROFEN
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RUT
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CRYSTAL STRUCTURE OF MURINE CYCLOOXYGENASE-2 WITH 13-METHYL-ARACHIDONIC ACID
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING CO, ...
Authors:Xu, S., Kudalkar, S.N., Banerjee, S., Makriyannis, A., Nikas, S.P., Marnett, L.J.
Deposit date:2014-11-21
Release date:2015-02-11
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:13-methylarachidonic Acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.
J.Biol.Chem., 290, 2015
4Z0L
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THE MURINE CYCLOOXYGENASE-2 COMPLEXED WITH A NIDO-DICARBABORATE-CONTAINING INDOMETHACIN DERIVATIVE
Descriptor:Prostaglandin G/H synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, S., Neumann, W., Banerjee, S., Hey-Hawkins, E., Marnett, L.J.
Deposit date:2015-03-26
Release date:2015-06-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.
Chemmedchem, 11, 2016
5W58
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CRYSTAL COMPLEX OF CYCLOOXYGENASE-2: (S)-ARN-2508 (A DUAL COX AND FAAH INHIBITOR)
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Goodman, M.C., Banerjee, S., Piomelli, D., Marnett, L.J.
Deposit date:2017-06-14
Release date:2018-01-31
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.267 Å)
Cite:Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
J. Biol. Chem., 293, 2018
6BL3
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CRYSTAL COMPLEX OF CYCLOOXYGENASE-2 WITH INDOMETHACIN-BUTYLDIAMINE-DANSYL CONJUGATE
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.
Deposit date:2017-11-09
Release date:2018-11-14
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.217 Å)
Cite:Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.
J.Biol.Chem., 294, 2019
6BL4
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CRYSTAL COMPLEX OF CYCLOOXYGENASE-2 WITH INDOMETHACIN-ETHYLENEDIAMINE-DANSYL CONJUGATE
Descriptor:Prostaglandin G/H synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.
Deposit date:2017-11-09
Release date:2018-11-14
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.
J.Biol.Chem., 294, 2019
1AG3
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DUPLEX OLIGODEOXYNUCLEOTIDE CONTAINING PROPANODEOXYGUANOSINE OPPOSITE A TWO-BASE DELETION, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:DNA (5'-D(*AP*TP*CP*GP*CP*PP*CP*GP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*CP*CP*GP*CP*GP*AP*T)-3')
Authors:Weisenseel, J.P., Stone, M.P.
Deposit date:1997-03-31
Release date:1997-07-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frame shift hotspot of Salmonella typhimurium hisD3052 determined by 1H NMR and restrained molecular dynamics.
Biochemistry, 34, 1995
2R8G
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SELECTIVITY OF NUCLEOSIDE TRIPHOSPHATE INCORPORATION OPPOSITE 1,N2-PROPANODEOXYGUANOSINE (PDG) BY THE SULFOLOBUS SOLFATARICUS DNA POLYMERASE DPO4 POLYMERASE
Descriptor:5'-D(*DGP*DGP*DGP*DGP*DGP*DAP*DAP*DGP*DGP*DAP*DTP*DTP*DT)-3', 5'-D(*DTP*DCP*DAP*DCP*(P)P*DGP*DAP*DAP*DAP*DTP*DCP*DCP*DTP*DTP*DCP*DCP*DCP*DCP*DC)-3', DNA polymerase IV, ...
Authors:Wang, Y., Saleh, S., Marnette, L.J., Egli, M., Stone, M.P.
Deposit date:2007-09-10
Release date:2008-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV
Biochemistry, 47, 2008
2R8H
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SELECTIVITY OF NUCLEOSIDE TRIPHOSPHATE INCORPORATION OPPOSITE 1,N2-PROPANODEOXYGUANOSINE (PDG) BY THE SULFOLOBUS SOLFATARICUS DNA POLYMERASE DPO4 POLYMERASE
Descriptor:DNA (5'-D(*DGP*DGP*DGP*DGP*DGP*DAP*DAP*DGP*DGP*DAP*DTP*DTP*DC)-3'), DNA (5'-D(*DTP*DCP*DAP*DCP*(P)P*DGP*DAP*DAP*DTP*DCP*DCP*DTP*DTP*DCP*DCP*DCP*DCP*DC)-3'), DNA polymerase IV, ...
Authors:Wang, Y., Saleh, S., Marnette, L.J., Egli, M., Stone, M.P.
Deposit date:2007-09-10
Release date:2008-07-22
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV
Biochemistry, 47, 2008
2R8I
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SELECTIVITY OF NUCLEOSIDE TRIPHOSPHATE INCORPORATION OPPOSITE 1,N2-PROPANODEOXYGUANOSINE (PDG) BY THE SULFOLOBUS SOLFATARICUS DNA POLYMERASE DPO4 POLYMERASE
Descriptor:DNA (5'-D(*DGP*DGP*DGP*DGP*DGP*DAP*DAP*DGP*DGP*DAP*DTP*DTP*DC)-3'), DNA (5'-D(*DTP*DCP*DAP*DTP*(P)P*DGP*DAP*DAP*DTP*DCP*DCP*DTP*DTP*DCP*DCP*DCP*DCP*DC)-3'), DNA polymerase IV, ...
Authors:Wang, Y., Saleh, S., Marnette, L.J., Egli, M., Stone, M.P.
Deposit date:2007-09-10
Release date:2008-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV
Biochemistry, 47, 2008
2OYE
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INDOMETHACIN-(R)-ALPHA-ETHYL-ETHANOLAMIDE BOUND TO CYCLOOXYGENASE-1
Descriptor:Prostaglandin G/H synthase 1, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Harman, C.A., Garavito, R.M.
Deposit date:2007-02-21
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
J.Biol.Chem., 282, 2007
2OYU
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INDOMETHACIN-(S)-ALPHA-ETHYL-ETHANOLAMIDE BOUND TO CYCLOOXYGENASE-1
Descriptor:Prostaglandin G/H synthase 1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Harman, C.A., Garavito, R.M.
Deposit date:2007-02-23
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
J.Biol.Chem., 282, 2007
6BJE
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CRYSTAL STRUCTURE OF LYSOPHOSPHOLIPASE A2 CONJUGATED WITH PHENYLMETHYLSULFONYL FLUORIDE
Descriptor:Acyl-protein thioesterase 2, phenylmethanesulfonic acid
Authors:Xu, S.
Deposit date:2017-11-06
Release date:2018-11-14
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.
J. Lipid Res., 60, 2019
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