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4A14
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HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
Descriptor:KINESIN-LIKE PROTEIN KIF7, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Klejnot, M., Kozielski, F.
Deposit date:2011-09-14
Release date:2012-01-25
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
4A1Z
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EG5-1
Descriptor:KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, NITRATE ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2011-09-20
Release date:2012-10-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4A28
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EG5-2
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2011-09-22
Release date:2012-10-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4A5Y
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INTERMEDIATE STATE OF HUMAN KINESIN EG5 IN COMPLEX WITH ISPINESIB
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2011-10-29
Release date:2012-11-07
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:"Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5.
J.Biol.Chem., 288, 2013
4AP0
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THE MITOTIC KINESIN EG5 IN COMPLEX WITH MG-ADP AND ISPINESIB
Descriptor:KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Schuettelkopf, A.W., Talapatra, S.K., Kozielski, F.
Deposit date:2012-03-30
Release date:2012-09-26
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.594 Å)
Cite:The Structure of the Ternary Eg5-Adp-Ispinesib Complex
Acta Crystallogr.,Sect.D, 68, 2012
4AS7
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EG5 COMPLEX 1
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2012-04-29
Release date:2013-05-15
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4B7B
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EG5-3
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2012-08-17
Release date:2013-07-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4BEX
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STRUCTURE OF HUMAN COFILIN1
Descriptor:COFILIN-1
Authors:Klejnot, M., Gabrielsen, M., Cameron, J., Mleczak, A., Talapatra, S.K., Kozielski, F., Pannifer, A., Olson, M.F.
Deposit date:2013-03-12
Release date:2013-08-28
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Analysis of the Human Cofilin1 Structure Reveals Conformational Changes Required for Actin-Binding
Acta Crystallogr.,Sect.D, 69, 2013
4BN2
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THE CRYSTAL STRUCTURE OF KINESIN-LIKE PROTEIN KIF15
Descriptor:KINESIN-LIKE PROTEIN KIF15, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Klejnot, M., Falnikar, A., Ulaganathan, V., Cross, R., Baas, P., Kozielski, F.
Deposit date:2013-05-13
Release date:2014-01-15
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:The Crystal Structure and Biochemical Characterization of Kif15: A Bifunctional Molecular Motor Involved in Bipolar Spindle Formation and Neuronal Development
Acta Crystallogr.,Sect.D, 70, 2014
4BXN
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EG5(WT) COMPLEX
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ...
Authors:Talapatra, S.K., Anthony, N.G., Mackay, S.P., Kozielski, F.
Deposit date:2013-07-15
Release date:2013-07-31
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (2.793 Å)
Cite:The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
5NJU
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FLAVIVIRUS NS5 DOMAIN
Descriptor:Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, MAGNESIUM ION
Authors:Talapatra, S.K., Chatrin, C., Kozielski, F.
Deposit date:2017-03-29
Release date:2018-01-24
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping.
Oncotarget, 9, 2018
5NJV
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FLAVIVIRUS NS5 DOMAIN
Descriptor:NS5, S-ADENOSYLMETHIONINE, CHLORIDE ION
Authors:Talapatra, S.K., Chatrin, C., Kozielski, F.
Deposit date:2017-03-29
Release date:2018-01-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping.
Oncotarget, 9, 2018
6FMP
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KEAP1 - PEPTIDE COMPLEX
Descriptor:Kelch-like ECH-associated protein 1, ACY-ASP-GLU-GLU-THR-GLY-GLU-PHE, ACETATE ION, ...
Authors:Talapatra, S.K., Kozielski, F., Wells, G., Georgakopoulos, N.D.
Deposit date:2018-02-01
Release date:2018-08-08
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids.
Chembiochem, 19, 2018
6FMQ
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KEAP1 - PEPTIDE COMPLEX
Descriptor:Kelch-like ECH-associated protein 1, ACY-SC1-GLU-THR-GLY-GLU-LEU, 1,2-ETHANEDIOL, ...
Authors:Talapatra, S.K., Kozielski, F., Wells, G., Georgakopoulos, N.D.
Deposit date:2018-02-02
Release date:2018-08-08
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids.
Chembiochem, 19, 2018
6G6Y
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EG5-INHIBITOR COMPLEX
Descriptor:Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Talapatra, S.K., Kozielski, F., Tham, C.L.
Deposit date:2018-04-03
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Eur J Med Chem, 156, 2018
1CZ7
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THE CRYSTAL STRUCTURE OF A MINUS-END DIRECTED MICROTUBULE MOTOR PROTEIN NCD REVEALS VARIABLE DIMER CONFORMATIONS
Descriptor:MICROTUBULE MOTOR PROTEIN NCD, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Kozielski, F.K., De Bonis, S., Burmeister, W., Cohen-Addad, C., Wade, R.
Deposit date:1999-09-01
Release date:1999-11-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations.
Structure Fold.Des., 7, 1999
3PYM
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STRUCTURE OF GAPDH 3 FROM S.CEREVISIAE AT 2.0 A RESOLUTION
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase 3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, MESO-ERYTHRITOL, ...
Authors:Garcia-Saez, I., Kozielski, F., Job, D., Boscheron, C.
Deposit date:2010-12-13
Release date:2012-01-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:

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