Author results

5YBJ
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STRUCTURE OF APO KANK1 ANKYRIN DOMAIN
Descriptor:KN motif and ankyrin repeat domain-containing protein 1, GLYCEROL
Authors:Guo, Q., Liao, S., Min, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2017-09-05
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.341 Å)
Cite:Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
J. Biol. Chem., 293, 2018
5YBU
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STRUCTURE OF THE KANK1 ANKYRIN DOMAIN IN COMPLEX WITH KIF21A PEPTIDE
Descriptor:KN motif and ankyrin repeat domain-containing protein 1, Kinesin-like protein KIF21A
Authors:Guo, Q., Liao, S., Min, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2017-09-05
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
J. Biol. Chem., 293, 2018
5YBV
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THE STRUCTURE OF THE KANK2 ANKYRIN DOMAIN WITH THE KIF21A PEPTIDE
Descriptor:KN motif and ankyrin repeat domain-containing protein 2, Kinesin-like protein KIF21A, SULFATE ION, ...
Authors:Guo, Q., Liao, S., Min, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2017-09-05
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
J. Biol. Chem., 293, 2018
6D4B
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CRYSTAL STRUCTURE OF CANDIDA BOIDINII FORMATE DEHYDROGENASE V123A MUTANT COMPLEXED WITH NAD+ AND AZIDE
Descriptor:Formate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, AZIDE ION, ...
Authors:Guo, Q., Ye, H., Gakhar, L., Cheatum, C.M., Kohen, A.
Deposit date:2018-04-17
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of Candida boidinii formate dehydrogenase V123A mutant complexed with NAD+ and azide
To Be Published
6D4C
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CRYSTAL STRUCTURE OF CANDIDA BOIDINII FORMATE DEHYDROGENASE V123G MUTANT COMPLEXED WITH NAD+ AND AZIDE
Descriptor:Formate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, AZIDE ION, ...
Authors:Guo, Q., Ye, H., Gakhar, L., Cheatum, C.M., Kohen, A.
Deposit date:2018-04-17
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of Candida boidinii formate dehydrogenase V123G mutant complexed with NAD+ and azide
To Be Published
6EPC
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GROUND STATE 26S PROTEASOME (GS2)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (12.3 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EPD
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SUBSTRATE PROCESSING STATE 26S PROTEASOME (SPS1)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (15.4 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EPE
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SUBSTRATE PROCESSING STATE 26S PROTEASOME (SPS2)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (12.8 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EPF
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GROUND STATE 26S PROTEASOME (GS1)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (11.8 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EZ8
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HUMAN HUNTINGTIN-HAP40 COMPLEX STRUCTURE
Descriptor:Huntingtin, Factor VIII intron 22 protein
Authors:Guo, Q., Bin, H., Cheng, J., Pfeifer, G., Baumeister, W., Fernandez-Busnadiego, R., Kochanek, S.
Deposit date:2017-11-14
Release date:2018-02-21
Last modified:2018-03-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The cryo-electron microscopy structure of huntingtin.
Nature, 555, 2018
6ICT
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STRUCTURE OF SETD3 BOUND TO SAH AND METHYLATED ACTIN
Descriptor:Histone-lysine N-methyltransferase setd3, Actin, cytoplasmic 1, ...
Authors:Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2018-09-07
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
6ICV
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STRUCTURE OF SETD3 BOUND TO SAH AND UNMODIFIED ACTIN
Descriptor:Histone-lysine N-methyltransferase setd3, Actin, cytoplasmic 1, ...
Authors:Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2018-09-07
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
6K0X
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STRUCTURE OF N6AMT1-TRMT112 COMPLEX WITH SAM
Descriptor:Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYLMETHIONINE
Authors:Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2019-05-07
Release date:2019-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of HEMK2-TRM112 Complex with SAM
To Be Published
2X69
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X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA POLYMER
Descriptor:C-C MOTIF CHEMOKINE 3
Authors:Guo, Q., Ren, M., Tang, W.
Deposit date:2010-02-15
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
2X6G
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X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (D27A)
Descriptor:C-C MOTIF CHEMOKINE 3
Authors:Guo, Q., Ren, M., Tang, W.
Deposit date:2010-02-17
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
2X6L
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X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 BETA
Descriptor:C-C MOTIF CHEMOKINE 4, GLYCEROL
Authors:Guo, Q., Ren, M., Tang, W.
Deposit date:2010-02-17
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
2YPU
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HUMAN INSULIN DEGRADING ENZYME E111Q IN COMPLEX WITH INHIBITOR COMPOUND 41367
Descriptor:INSULIN-DEGRADING ENZYME, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.-J.
Deposit date:2012-11-01
Release date:2012-11-28
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis
Eur J Med Chem, 79C, 2014
3QZ2
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THE STRUCTURE OF CYSTEINE-FREE HUMAN INSULIN DEGRADING ENZYME
Descriptor:Insulin-degrading enzyme, ZINC ION
Authors:Guo, Q., Tang, W.J.
Deposit date:2011-03-04
Release date:2012-01-25
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DTT
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPUND 41367
Descriptor:Insulin-degrading enzyme, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-02-21
Release date:2013-02-27
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DWK
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STRUCTURE OF CYSTEIN FREE INSULIN DEGRADING ENZYME WITH COMPOUND BDM41671 ((S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPYL)-AMINO]-ACETYLAMINO}-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER)
Descriptor:Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-02-24
Release date:2013-04-03
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GS8
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STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH COMPOUND BDM43079 [{[(S)-2-(1H-IMIDAZOL-4-YL)-1-METHYLCARBAMOYL-ETHYLCARBAMOYL]-METHYL}-(3-PHENYL-PROPYL)-AMINO]-ACETIC ACID
Descriptor:Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GSC
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STRUCTURE ANALYSIS OF INSULIN DEGRADING ENZYME WITH COMPOUND BDM41559 ((S)-2-[2-(CARBOXYMETHYL-PHENETHYL-AMINO)-ACETYLAMINO]-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER)
Descriptor:Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4KR1
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CRYSTAL STRUCTURE OF THE KINETECHORE PROTEIN IML3 FROM BUDDING YEAST
Descriptor:Central kinetochore subunit IML3
Authors:Tao, Y., Guo, Q., Teng, M.
Deposit date:2013-05-16
Release date:2013-12-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly
Acta Crystallogr.,Sect.D, 69, 2013
1XFV
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 3' DEOXY-ATP
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Q., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1C8J
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CRYSTAL STRUCTURE OF CYTOCHROME P450CAM MUTANT (F87W/Y96F)
Descriptor:CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE
Authors:Liu, Y., Jiang, F., Guo, Q., Chen, X., Jin, J., Sun, Y., Rao, Z.
Deposit date:2000-05-31
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Cytochrome P450cam mutant (F87W/Y96F)
To be Published