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1BQ3
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BU of 1bq3 by Molmil
SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE IN COMPLEX WITH INOSITOL HEXAKISPHOSPHATE
Descriptor: INOSITOL HEXAKISPHOSPHATE, PROTEIN (PHOSPHOGLYCERATE MUTASE 1), SULFATE ION
Authors:Rigden, D.J, Phillips, S.E.V, Fothergill-Gilmore, L.A.
Deposit date:1998-08-20
Release date:1998-08-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis.
J.Mol.Biol., 289, 1999
1BQ4
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BU of 1bq4 by Molmil
SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE IN COMPLEX WITH BENZENE HEXACARBOXYLATE
Descriptor: BENZENE HEXACARBOXYLIC ACID, PROTEIN (PHOSPHOGLYCERATE MUTASE 1), SULFATE ION
Authors:Rigden, D.J, Phillips, S.E.V, Fothergill-Gilmore, L.A.
Deposit date:1998-08-20
Release date:1998-08-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis.
J.Mol.Biol., 289, 1999
1FZT
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BU of 1fzt by Molmil
SOLUTION STRUCTURE AND DYNAMICS OF AN OPEN B-SHEET, GLYCOLYTIC ENZYME-MONOMERIC 23.7 KDA PHOSPHOGLYCERATE MUTASE FROM SCHIZOSACCHAROMYCES POMBE
Descriptor: PHOSPHOGLYCERATE MUTASE
Authors:Uhrinova, S, Uhrin, D, Nairn, J, Price, N.C, Fothergill-Gilmore, L.A.
Deposit date:2000-10-04
Release date:2001-03-14
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure and dynamics of an open beta-sheet, glycolytic enzyme, monomeric 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombe.
J.Mol.Biol., 306, 2001
4PGM
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BU of 4pgm by Molmil
SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE
Descriptor: PHOSPHOGLYCERATE MUTASE 1
Authors:Rigden, D.J, Alexeev, D, Phillips, S.E.V, Fothergill-Gilmore, L.A.
Deposit date:1997-04-25
Release date:1997-10-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase.
J.Mol.Biol., 276, 1998
2HIG
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BU of 2hig by Molmil
Crystal Structure of Phosphofructokinase apoenzyme from Trypanosoma brucei.
Descriptor: 6-phospho-1-fructokinase, SODIUM ION
Authors:Martinez-Oyanedel, J, McNae, I.W, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2006-06-29
Release date:2007-02-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The First Crystal Structure of Phosphofructokinase from a Eukaryote: Trypanosoma brucei.
J.Mol.Biol., 366, 2007
1JI3
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BU of 1ji3 by Molmil
CRYSTAL STRUCTURE OF THE FIRST THERMOSTABLE BACTERIAL LIPASE FROM BACILLUS STEAROTHERMOPHILUS
Descriptor: CALCIUM ION, ZINC ION, lipase
Authors:Tyndall, J.D.A, Sinchaikul, S, Fothergill-Gilmore, L.A, Taylor, P, Walkinshaw, M.D.
Deposit date:2001-06-29
Release date:2002-11-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Thermostable Lipase from Bacillus stearothermophilus P1
J.Mol.Biol., 323, 2002
4KS0
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BU of 4ks0 by Molmil
Pyruvate kinase (PYK) from Trypanosoma cruzi in the presence of Magnesium, oxalate and F26BP
Descriptor: 2,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, OXALATE ION, ...
Authors:Morgan, H.P, Zhong, W, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2013-05-17
Release date:2014-11-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.
R Soc Open Sci, 1, 2014
5PGM
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BU of 5pgm by Molmil
SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE
Descriptor: ALANINE, PHOSPHOGLYCERATE MUTASE 1, SULFATE ION
Authors:Rigden, D.J, Phillips, S.E.V, Fothergill-Gilmore, L.A.
Deposit date:1998-08-19
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism.
J.Mol.Biol., 286, 1999
1PKL
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BU of 1pkl by Molmil
THE STRUCTURE OF LEISHMANIA PYRUVATE KINASE
Descriptor: PROTEIN (PYRUVATE KINASE), SULFATE ION
Authors:Rigden, D.J, Phillips, S.E.V, Michels, P.A.M, Fothergill-Gilmore, L.A.
Deposit date:1998-09-15
Release date:1998-09-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity.
J.Mol.Biol., 291, 1999
3F5M
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BU of 3f5m by Molmil
Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei
Descriptor: 6-phospho-1-fructokinase (ATP-dependent phosphofructokinase), ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:McNae, I.W, Martinez-Oyanedel, J, Keillor, J.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2008-11-04
Release date:2008-11-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases.
J.Mol.Biol., 385, 2009
3SRF
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BU of 3srf by Molmil
Human M1 pyruvate kinase
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRH
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BU of 3srh by Molmil
Human M2 pyruvate kinase
Descriptor: PHOSPHATE ION, Pyruvate kinase isozymes M1/M2
Authors:Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRD
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BU of 3srd by Molmil
Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and Oxalate.
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ...
Authors:Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRK
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BU of 3srk by Molmil
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
Descriptor: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, Pyruvate kinase, ...
Authors:Morgan, H.P, Walsh, M, Blackburn, E.A, Wear, M.A, Boxer, M, Shen, M, McNae, I.W, Michels, P.A.M, Auld, D.S, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-07-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
To be Published
5OFU
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BU of 5ofu by Molmil
Crystal structure of Leishmania major fructose-1,6-bisphosphatase in T-state.
Descriptor: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ...
Authors:Yuan, M, Vasquez-Valdivieso, M.G, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2017-07-11
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
5OEY
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BU of 5oey by Molmil
Crystal structure of Leishmania major fructose-1,6-bisphosphatase in holo form.
Descriptor: CITRIC ACID, FBP protein, MANGANESE (II) ION, ...
Authors:Yuan, M, Vasquez-Valdivieso, M.G, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2017-07-10
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
5OEZ
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BU of 5oez by Molmil
Crystal structure of Leishmania major fructose-1,6-bisphosphatase in apo form.
Descriptor: FBP protein
Authors:Yuan, M, Vasquez-Valdivieso, M.G, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2017-07-10
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
3PP7
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BU of 3pp7 by Molmil
Crystal structure of Leishmania mexicana pyruvate kinase in complex with the drug suramin, an inhibitor of glycolysis.
Descriptor: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, GLYCEROL, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2010-11-24
Release date:2010-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV9
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BU of 3qv9 by Molmil
Crystal structure of Trypanosoma cruzi pyruvate kinase(TcPYK)in complex with ponceau S.
Descriptor: 3-hydroxy-4-[(E)-{2-sulfo-4-[(E)-(4-sulfophenyl)diazenyl]phenyl}diazenyl]naphthalene-2,7-disulfonic acid, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-07-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV7
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Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with ponceau S and acid blue 25.
Descriptor: 3-hydroxy-4-[(E)-{2-sulfo-4-[(E)-(4-sulfophenyl)diazenyl]phenyl}diazenyl]naphthalene-2,7-disulfonic acid, 9,10-dioxo-4-(phenylamino)-9,10-dihydroanthracene-2-sulfonic acid, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV6
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Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with acid blue 80.
Descriptor: 3-({4-[(2,4-dimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracen-1-yl}amino)-2,4,6-trimethylbenzenesulfonic acid, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV8
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Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with benzothiazole-2,5-disulfonic acid.
Descriptor: 1,3-benzothiazole-2,5-disulfonic acid, PHOSPHATE ION, Pyruvate kinase
Authors:Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3IGY
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BU of 3igy by Molmil
Crystal structures of Leishmania mexicana phosphoglycerate mutase at high cobalt concentrations
Descriptor: 2-PHOSPHOGLYCERIC ACID, 3-PHOSPHOGLYCERIC ACID, COBALT (II) ION, ...
Authors:Nowicki, M.W, Kuaprasert, B, McNae, I.W, Morgan, H.P, Harding, M.M, Michels, P.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2009-07-29
Release date:2009-10-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
J.Mol.Biol., 394, 2009
3IGZ
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Crystal structures of Leishmania mexicana phosphoglycerate mutase at low cobalt concentration
Descriptor: 2-PHOSPHOGLYCERIC ACID, 3-PHOSPHOGLYCERIC ACID, COBALT (II) ION, ...
Authors:Nowicki, M.W, Kuaprasert, B, McNae, I.W, Morgan, H.P, Harding, M.M, Michels, P.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2009-07-29
Release date:2009-10-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
J.Mol.Biol., 394, 2009
4HYV
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BU of 4hyv by Molmil
Pyruvate kinase (PYK) from Trypanosoma brucei in the presence of Magnesium, PEP and F26BP
Descriptor: 2,6-di-O-phosphono-beta-D-fructofuranose, CHLORIDE ION, GLYCEROL, ...
Authors:Zhong, W, Morgan, H.P, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D.
Deposit date:2012-11-14
Release date:2013-09-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.
Acta Crystallogr.,Sect.D, 69, 2013

 

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