Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1DJ0
DownloadVisualize
BU of 1dj0 by Molmil
THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION
Descriptor: CHLORIDE ION, PSEUDOURIDINE SYNTHASE I
Authors:Foster, P.G, Huang, L, Santi, D.V, Stroud, R.M.
Deposit date:1999-11-30
Release date:2000-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I.
Nat.Struct.Biol., 7, 2000
2IST
DownloadVisualize
BU of 2ist by Molmil
crystal structure of RluD from E. coli
Descriptor: BICARBONATE ION, CHLORIDE ION, Ribosomal large subunit pseudouridine synthase D
Authors:Foster, P.G, Finer-Moore, J.S, Stroud, R.M.
Deposit date:2006-10-18
Release date:2006-10-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of RluD from E. coli
TO BE PUBLISHED
1SQF
DownloadVisualize
BU of 1sqf by Molmil
The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution
Descriptor: S-ADENOSYLMETHIONINE, SUN protein
Authors:Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M.
Deposit date:2004-03-18
Release date:2004-05-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The First Structure of an RNA m5C Methyltransferase, Fmu, Provides Insight into Catalytic Mechanism and Specific Binding of RNA Substrate
Structure, 11, 2003
1SQG
DownloadVisualize
BU of 1sqg by Molmil
The crystal structure of the E. coli Fmu apoenzyme at 1.65 A resolution
Descriptor: SUN protein
Authors:Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M.
Deposit date:2004-03-18
Release date:2004-05-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The First Structure of an RNA m5C Methyltransferase, Fmu, Provides Insight into Catalytic Mechanism and Specific Binding of RNA Substrate
Structure, 11, 2003
4ANW
DownloadVisualize
BU of 4anw by Molmil
Complexes of PI3Kgamma with isoform selective inhibitors.
Descriptor: 3-AMINO-6-{4-CHLORO-3-[(2,3-DIFLUOROPHENYL)SULFAMOYL]PHENYL}-N-METHYLPYRAZINE-2-CARBOXAMIDE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION
Authors:Foster, P.G, Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
4ANU
DownloadVisualize
BU of 4anu by Molmil
Complexes of PI3Kgamma with isoform selective inhibitors.
Descriptor: 3-AMINO-N-METHYL-6-[3-(1H-TETRAZOL-5-YL)PHENYL]PYRAZINE-2-CARBOXAMIDE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION
Authors:Foster, P.G, Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
4ANX
DownloadVisualize
BU of 4anx by Molmil
Complexes of PI3Kgamma with isoform selective inhibitors.
Descriptor: 5-{3-[(4-{3-[4-(1-methylethyl)phenyl]pyrazin-2-yl}piperazin-1-yl)sulfonyl]phenyl}pyrimidin-2-amine, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
Authors:Foster, P.G, Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
4ANV
DownloadVisualize
BU of 4anv by Molmil
Complexes of PI3Kgamma with isoform selective inhibitors.
Descriptor: 2-{4-[(4'-METHOXYBIPHENYL-3-YL)SULFONYL]PIPERAZIN-1-YL}-3-(4-METHOXYPHENYL)PYRAZINE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION
Authors:Foster, P.G, Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
1KEZ
DownloadVisualize
BU of 1kez by Molmil
Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE)
Descriptor: ERYTHRONOLIDE SYNTHASE
Authors:Tsai, S.-C, Miercke, L.J.W, Krucinski, J, Gokhale, R, Chen, J.C.-H, Foster, P.G, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2001-11-19
Release date:2002-01-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proc.Natl.Acad.Sci.USA, 98, 2001
3FLI
DownloadVisualize
BU of 3fli by Molmil
Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)
Descriptor: 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate, Bile acid receptor
Authors:Foster, P.G, Stout, T.J.
Deposit date:2008-12-18
Release date:2009-12-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).
J.Med.Chem., 52, 2009
1BPJ
DownloadVisualize
BU of 1bpj by Molmil
THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, POTASSIUM ION, PROTEIN (THYMIDYLATE SYNTHASE)
Authors:Morse, R.J, Finer-Moore, J.S, Stroud, R.M.
Deposit date:1998-08-11
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BO7
DownloadVisualize
BU of 1bo7 by Molmil
THYMIDYLATE SYNTHASE R179T MUTANT
Descriptor: PROTEIN (THYMIDYLATE SYNTHASE), URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R, Finer-Moore, J, Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP0
DownloadVisualize
BU of 1bp0 by Molmil
THYMIDYLATE SYNTHASE R23I MUTANT
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, POTASSIUM ION, PROTEIN (THYMIDYLATE SYNTHASE)
Authors:Morse, R, Finer-Moore, J, Stroud, R.M.
Deposit date:1998-08-11
Release date:2000-01-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP6
DownloadVisualize
BU of 1bp6 by Molmil
THYMIDYLATE SYNTHASE R23I, R179T DOUBLE MUTANT
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, POTASSIUM ION, PROTEIN (THYMIDYLATE SYNTHASE)
Authors:Morse, R.J, Finer-Moore, J.S, Stroud, R.M.
Deposit date:1998-08-13
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BO8
DownloadVisualize
BU of 1bo8 by Molmil
THYMIDYLATE SYNTHASE R178T MUTANT
Descriptor: POTASSIUM ION, PROTEIN (THYMIDYLATE SYNTHASE), URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R, Finer-Moore, J, Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1LCA
DownloadVisualize
BU of 1lca by Molmil
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717
Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1995-06-22
Release date:1995-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1LCB
DownloadVisualize
BU of 1lcb by Molmil
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DTMP AND H2FOLATE
Descriptor: DIHYDROFOLIC ACID, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1995-06-22
Release date:1995-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1LCE
DownloadVisualize
BU of 1lce by Molmil
LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1995-06-22
Release date:1995-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
2TDM
DownloadVisualize
BU of 2tdm by Molmil
STRUCTURE OF THYMIDYLATE SYNTHASE
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Finer-Moore, J, Stroud, R.M.
Deposit date:1997-03-28
Release date:1997-08-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1THY
DownloadVisualize
BU of 1thy by Molmil
REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Finer-Moore, J, Stroud, R.
Deposit date:1993-04-02
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1NJA
DownloadVisualize
BU of 1nja by Molmil
THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)
Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Finer-Moore, J, Stroud, R.M.
Deposit date:1996-01-23
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJB
DownloadVisualize
BU of 1njb by Molmil
THYMIDYLATE SYNTHASE
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Finer-Moore, J, Stroud, R.M.
Deposit date:1996-01-23
Release date:1996-10-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJD
DownloadVisualize
BU of 1njd by Molmil
THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Finer-Moore, J, Stroud, R.M.
Deposit date:1996-01-23
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJC
DownloadVisualize
BU of 1njc by Molmil
THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)
Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Finer-Moore, J, Stroud, R.M.
Deposit date:1996-01-23
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
1NJE
DownloadVisualize
BU of 1nje by Molmil
THYMIDYLATE SYNTHASE WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)
Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Finer-Moore, J, Stroud, R.M.
Deposit date:1996-01-23
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon