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6Y3X
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BU of 6y3x by Molmil
Crystal structure of the Francisella novicida lysine decarboxylase LdcF
Descriptor: Lysine decarboxylase
Authors:Felix, J, Siebert, C, Gutsche, I, Renesto, P.
Deposit date:2020-02-19
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance.
Sci Rep, 11, 2021
4WRL
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BU of 4wrl by Molmil
Structure of the human CSF-1:CSF-1R complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor, ...
Authors:Felix, J, De Munck, S, Elegheert, J, Savvides, S.N.
Deposit date:2014-10-24
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
4WRM
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BU of 4wrm by Molmil
Structure of the human CSF-1:CSF-1R complex
Descriptor: Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor
Authors:Felix, J, De Munck, S, Elegheert, J, Savvides, S.N.
Deposit date:2014-10-24
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (6.853 Å)
Cite:Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
5D28
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BU of 5d28 by Molmil
Complex of GM-CSF/IL-2 inhibition factor with Granulocyte-macrophage colony-stimulating factor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GM-CSF/IL-2 inhibition factor, ...
Authors:Felix, J, Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
5D22
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BU of 5d22 by Molmil
Structure of ovine granulocyte-macrophage colony-stimulating factor
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Granulocyte-macrophage colony-stimulating factor
Authors:Felix, J, Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
6HWN
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BU of 6hwn by Molmil
Structure of Thermus thermophilus ClpP in complex with a tripeptide.
Descriptor: ATP-dependent Clp protease proteolytic subunit, DI(HYDROXYETHYL)ETHER, Unknown tripeptide
Authors:Felix, J, Schanda, P, Fraga, H, Morlot, C.
Deposit date:2018-10-12
Release date:2019-09-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.
Sci Adv, 5, 2019
6HWM
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BU of 6hwm by Molmil
Structure of Thermus thermophilus ClpP in complex with bortezomib
Descriptor: ATP-dependent Clp protease proteolytic subunit, DI(HYDROXYETHYL)ETHER, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
Authors:Felix, J, Schanda, P, Fraga, H, Morlot, C.
Deposit date:2018-10-12
Release date:2019-09-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.
Sci Adv, 5, 2019
8A8W
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BU of 8a8w by Molmil
Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Ecumycin (class 1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide
Authors:Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K.
Deposit date:2022-06-24
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
J.Biol.Chem., 298, 2022
8A8U
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BU of 8a8u by Molmil
Mycobacterium tuberculosis ClpC1 hexamer structure
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide
Authors:Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K.
Deposit date:2022-06-24
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
J.Biol.Chem., 298, 2022
8A8V
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BU of 8a8v by Molmil
Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Cyclomarin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide
Authors:Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K.
Deposit date:2022-06-24
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
J.Biol.Chem., 298, 2022
6YN6
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BU of 6yn6 by Molmil
Inducible lysine decarboxylase LdcI stacks, pH 5.7
Descriptor: Inducible lysine decarboxylase
Authors:Felix, J, Jessop, M, Desfosses, A, Effantin, G, Gutsche, I.
Deposit date:2020-04-10
Release date:2021-01-13
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Supramolecular assembly of the Escherichia coli LdcI upon acid stress.
Proc.Natl.Acad.Sci.USA, 118, 2021
7PQH
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BU of 7pqh by Molmil
Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains).
Descriptor: Serine/threonine-protein kinase TOR2, Target of rapamycin complex 1 subunit KOG1,Target of rapamycin complex 1 subunit Kog1, Target of rapamycin complex subunit LST8
Authors:Felix, J, Prouteau, M, Bourgoint, C, Bonadei, L, Desfosses, A, Gabus, C, Sadian, Y, Savvides, S.N, Gutsche, I, Loewith, R.
Deposit date:2021-09-17
Release date:2023-01-18
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:EGOC inhibits TOROID polymerization by structurally activating TORC1.
Nat.Struct.Mol.Biol., 30, 2023
8PB1
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BU of 8pb1 by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ...
Authors:Felix, J, Bloch, Y, Savvides, S.N.
Deposit date:2023-06-08
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
8OE0
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BU of 8oe0 by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ...
Authors:Felix, J, Bloch, Y, Savvides, S.N.
Deposit date:2023-03-10
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
8ODZ
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BU of 8odz by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ...
Authors:Felix, J, Bloch, Y, Savvides, S.N.
Deposit date:2023-03-10
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
6YN5
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BU of 6yn5 by Molmil
Inducible lysine decarboxylase LdcI decamer, pH 7.0
Descriptor: Inducible lysine decarboxylase
Authors:Jessop, M, Felix, J, Desfosses, A, Effantin, G, Gutsche, I.
Deposit date:2020-04-10
Release date:2021-01-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Supramolecular assembly of the Escherichia coli LdcI upon acid stress.
Proc.Natl.Acad.Sci.USA, 118, 2021
7CCH
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BU of 7cch by Molmil
Acinetobacter baumannii histidine kinase AdeS
Descriptor: AdeS
Authors:Wen, Y, Felix, J.
Deposit date:2020-06-17
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.848 Å)
Cite:Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS.
Iscience, 24, 2021
4PU8
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BU of 4pu8 by Molmil
Shewanella oneidensis Toxin Antitoxin System Antitoxin Protein HipB Resolution 2.35
Descriptor: Toxin-antitoxin system antidote transcriptional repressor Xre family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU3
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BU of 4pu3 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P212121)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU5
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BU of 4pu5 by Molmil
Shewanella oneidensis Toxin Antitoxin System Toxin Protein HipA Bound with AMPPNP and Mg
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ...
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.834 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU4
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BU of 4pu4 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P21)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.786 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU7
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BU of 4pu7 by Molmil
Shewanella oneidensis Toxin Antitoxin System Antitoxin Protein HipB Resolution 1.85
Descriptor: Toxin-antitoxin system antidote transcriptional repressor Xre family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
6Q7M
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BU of 6q7m by Molmil
Spiral structure of E. coli RavA in the RavA-LdcI cage-like complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATPase RavA, Inducible lysine decarboxylase, ...
Authors:Arragain, B, Felix, J, Malet, H, Gutsche, I, Jessop, M.
Deposit date:2018-12-13
Release date:2020-02-12
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.
Commun Biol, 3, 2020
6Q7L
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BU of 6q7l by Molmil
Spiral structure of E. coli RavA in the RavA-LdcI cage-like complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATPase RavA, Inducible lysine decarboxylase, ...
Authors:Arragain, B, Felix, J, Malet, H, Gutsche, I, Jessop, M.
Deposit date:2018-12-13
Release date:2020-02-12
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.
Commun Biol, 3, 2020
6JJJ
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BU of 6jjj by Molmil
Trimeric structure of Kupffer cell C-type lectin receptor Clec4f
Descriptor: C-type lectin domain family 4 member F, CALCIUM ION
Authors:Wen, Y, Ouyang, Z, Felix, J.
Deposit date:2019-02-26
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.
Febs Lett., 594, 2020

 

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PDB entries from 2024-03-27

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